I wonder if anyone knows why or has experienced a rise on PSA level (from 70 to 274), 6 months after radiation therapy (VMAT x 26 sessions)?

[Iloveyoudad]

Before and after radiation therapy, dad was taking Bicalutamide 50 mg and Alfuzosin50 mg together with a quarterly Leuprorelin injection. This month (October), after receiving his Leuprorelin injection, Urologist advised to stop taking Bicalutamide as it is no longer effective due to hormone resistance resulting to a rise on PSA level. Instead, take Abiraterone Acetate with Prednisone.

[Tall_Allen]

Please add his current diagnosis to his profile.

[Iloveyoudad in reply to Tall_Allen]

Hi Sir, just updated details to his profile. Thank you very much

[Tall_Allen in reply to Iloveyoudad]

Thanks. So he has lung metastases, and he was given Lupron with only Casodex? I don't understand that, but I'm glad he is getting abiraterone now.

The radiation he received was only for debulking purposes and was never meant to be curative.

[Iloveyoudad in reply to Tall_Allen]

Should he be given other medications besides Lupron and Casodex at that time? Thank you

[Kiki27]

My husband’s psa has risen after every treatment. When he first began his journey with the hormone therapy, it initially went down and pretty quickly started to go back up. Then he started with Docetaxel, same thing it went down initially and briefly, then started to climb. He’s now on Pluvicto and it still continues to bounce back up. It’s so upsetting. I really hate the psa.

[Iloveyoudad in reply to Kiki27]

Hi Ma'am, I read something regarding Pluvicto being the best cure. But from what I know, this medication isn't available yet in my country, Philippines.

[j-o-h-n]

For my lung cancer due to Melanoma metastases I was treated with KEYTRUDA and it worked - MSKcc in NYC..... Ask Doc? I think it may not be applicable for Pca...... (I Loved MY Dad also and he passed on April 16, 1955).....Good Bless your Dad and God Bless you.....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 10/13/ 2023 4:35 PM DST -- Ex wife's birthday.