I made this chart which shows the historical timeline of Estrogen use for treating prostate cancer.
Estrogen has been used for about 85 years, with various forms of delivery.
With the exception of high-dose oral estrogen (DES) causing blood clots from 1945 to 1970, the other forms of estrogen (e.g., transdermal) have had a very successful history.
Most doctors have forgotten, or never learned, about the long history of estrogen use.
Bob
They should go back to estrogen to block testosterone / DHT this time using patches or gel
Yes, I agree!
The results of the UK Phase-III PATCH trial should be published this Fall. It will compare 5- year and 10-year survival outcomes between estrogen patches and Lupron ADT.
We are predicting that the survival outcomes will be no different between the two drugs, because they both work on the same mechanism of suppressing LH and FSH hormones, thereby reducing testosterone to close to zero. The benefit of doing transdermal estrogen (TDE) is the elimination of most of the bad side effects from Lupron ADT. Plus, it's a lot cheaper.
The primary side effect of high-dose estrogen is increased gynecomastia, which can be a severe psychological problem for some men. Other side effects of TDE include muscle weakness and increased risk of breast cancer, primarily in men with BRCA 1/2 mutations. Men considering Estrogen therapy should have their BRCA gene status tested. I used the free gene test at promisecncerregistry.org, and it was easy to use (saliva test).
From Ai
Estrogen is a group of hormones that play a key role in the development and regulation of the female reproductive system and secondary sexual characteristics. These hormones are primarily produced in the ovaries, although smaller amounts are also produced in other tissues, such as the adrenal glands and fat cells. Estrogen influences various bodily functions, including the menstrual cycle, bone density, cholesterol levels, and mood regulation. It also plays a role in maintaining the health of the reproductive tissues, such as the uterus and vagina. Additionally, estrogen has effects on other systems in the body, including the cardiovascular, skeletal, and central nervous systems.
Good Luck, Good Health and Good Humor.
j-o-h-n
Hmmm. Muscle weakness. If E reduces testosterone to near zero then I would think our common phrase "muscle loss" would be more appropriate.
You are absolutely correct. I should have listed muscle loss as a side effect of estrogen therapy.
Thank you.
MO is recommending EstroDIM
Relief from hot flashes?
