I am taking Azilect 1 MG, along with two other meds, (Amantadine & Carbidopa-Levo).
I was experiencing sleep problems and told my PD neurologist, who prescibed Trazodone 50 MG Tablet....Directions instruct: TAKE ONE TABLET BY MOUTH AT BEDTIME INCREASING TO 2 TABLETS IF NEEDED FOR SLEEP.
Earlier this year I shared this information with another person on HealthUnlocked, PD blog.
After doing this another PD person wrote a response saying it was very dangerous.....This "frightened" me, so even though my PD doctor prescribed it, I haven't used it yet.
This morning I found this...(I should have just called my PD doctor)
While taking antidepressants with Azilect is "normally" not recommended because of serious effects.....there was a a study that allowed the type my PD doctor prescribed me. Here is my finding found on the net this morning.
Dr. Sanchez-Ramos said...
Thursday, February 23, 2012
I looked into the warning on the use of AZILECT with anti-depressants. After reading this material, speak to your neurologist about the anti-depressant to use. Also you can show this to your Pharmacist. You should know that certain antidepressants were allowed in all AZILECT Phase III clinical trials without adverse effects.
TEVA the producer of AZILECT provided the following information:
• The following antidepressants and doses were allowed in AZILECT Phase III clinical trials:
Generic name, Brand name, Class, Dose allowed
Amitriptyline, Elavil®, Endep®, Vanatrip® tricyclic =50 mg/day
Paroxetine, Paxil®, Paxil CR®, Pexeva® SSRI =30 mg/day
Sertraline, Zoloft® SSRI =100 mg/day
Escitalopram, Lexapro® SSRI =10 mg/day
Citalopram, Celexa® SSRI =20 mg/day
Trazodone, Desyrel® triazolopyridine =100 mg/day
• Trials with AZILECT did not allow use of fluoxetine (Prozac®) or fluvoxamine (Luvox®)
Coadministration with antidepressants is a warning associated
with selective MAO-B inhibitors (AZILECT and DEPRENYL)
• Antidepressants are not contraindicated with AZILECT
• AZILECT labeling contains a warning regarding use with antidepressants:
“…it seems prudent, in general, to avoid the combination of AZILECT with any antidepressant.”
Be aware of the risks and use clinical judgment
• AZILECT label outlines the potential risks of an antidepressant interaction, including an
increased risk of developing serotonin syndrome
• Of 2487 patients in trials, 477 received both AZILECT and an antidepressant with no
reported serious or nonserious adverse events consistent with serotonin syndrome. However, the exposure, both in dose and number of subjects, was not adequate to rule out the possibility of an untoward reaction from combining these agents.
• In the postmarketing period, nonfatal cases of serotonin syndrome have been
reported in patients treated with antidepressants concomitantly with AZILECT
• Use caution and apply clinical judgment when using AZILECT to treat
PD patients who take an antidepressant
I have a good PD neurologist, who is very well known in the PD field in our area....He is on the panel of experts, when there is a Parkinsons symposium in my area......I should have listened and not have been "frightened off" by a "well meaning" , fellwow PD blogger.
I just wanted to state this and say, If you have a good PD neurologist, "call him or her with your concerns". I did not and it cost me many nights sleep.