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Any advice about weaning off of levodopa and starting amantadine.

I have developed dyskinesia and doctors tried reducing levodopa thinking I was getting too much but dyskinesia persisted.
I have developed dyskinesia and doctors tried reducing levodopa thinking I was getting too much but dyskinesia persisted.
miller15 profile image
miller15
in Cure Parkinson's

AUSTEDO; Finally, a pharmaceutical that causes Parkinson's!! A drug for tardive-dyskinesia, dyskinesia caused by other drugs.

"Dopamine receptor-blocking medications (dopamine antagonists) are most likely to cause tardive dyskinesia. " https://my.clevelandclinic.org/health/articles/6125-tardive-dyskinesia
"Dopamine receptor-blocking medications (dopamine antagonists) are most likely to cause tardive dyskinesia. " https://my.clevelandclinic.org/health/articles/6125-tardive-dyskinesia
MBAnderson profile image
MBAnderson
in Cure Parkinson's

HOW CAN I REDUCE MY DYSKINESIA?

I am desperate for suggestions on reducing dyskinesia. I have had gate and balance dominant PD for 11 years now and have always struggled with dyskinesia. Recently I had a fractured femur and am attempting to resume walking with the the help of a walker.
I am desperate for suggestions on reducing dyskinesia. I have had gate and balance dominant PD for 11 years now and have always struggled with dyskinesia. Recently I had a fractured femur and am attempting to resume walking with the the help of a walker.
Joanne_Joyce profile image
Joanne_Joyce
in Cure Parkinson's
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Oral Molecule PD13R Safely Eases Dyskinesia Tied to Levodopa in Primate Model

Notably, in contrast to Gocovri (amantadine) — an approved therapy to treat levodopa-induced dyskinesia — PD13R did not affect the animals’ sleep, suggesting this new molecule may be a safer as well as effective in treating dyskinesia, the researchers noted.
Notably, in contrast to Gocovri (amantadine) — an approved therapy to treat levodopa-induced dyskinesia — PD13R did not affect the animals’ sleep, suggesting this new molecule may be a safer as well as effective in treating dyskinesia, the researchers noted.
nedim profile image
nedim
in Cure Parkinson's

Dyskinesia after short term use of Levo-Dopa?

has anyone ever heard of (facial/oro) dyskinesia being induced by only 6 months use of L-Dopa and from such a relatively low dose?
has anyone ever heard of (facial/oro) dyskinesia being induced by only 6 months use of L-Dopa and from such a relatively low dose?
Tomkins profile image
Tomkins
in Cure Parkinson's

Dyskinesia Question

I have gait issues including dropfoot which disappeared with the meds however over the past couple of months I've started developing dyskinesia. Can dyskinesia develop so quickly all of a sudden in such a short space of time when my dosage hasn't changed?
I have gait issues including dropfoot which disappeared with the meds however over the past couple of months I've started developing dyskinesia. Can dyskinesia develop so quickly all of a sudden in such a short space of time when my dosage hasn't changed?
Wilso77 profile image
Wilso77
in Cure Parkinson's

Ketamine

Has anyone tried Ketamine for PD dyskinesia or depression associated with PD? There is a clinical trial opening in my area and I am trying to decide whether or not to participate. My dyskinesia is mild. Thanks!
Has anyone tried Ketamine for PD dyskinesia or depression associated with PD? There is a clinical trial opening in my area and I am trying to decide whether or not to participate. My dyskinesia is mild. Thanks!
Canddy profile image
Canddy
in Cure Parkinson's

AMANTADINE FOR DYSKINESIA. HAVE YOU AN EXPERIENCE WITH THIS DRUG? PLEASE HELP.

Hi, I might consider this drug for Dyskinesia, if it gets too severe. My MDS is a little reluctant to prescribe it, because he says it may cause insomnia. Nevertheless, is this drug working for your dyskinesia? How long before it started working for you?
Hi, I might consider this drug for Dyskinesia, if it gets too severe. My MDS is a little reluctant to prescribe it, because he says it may cause insomnia. Nevertheless, is this drug working for your dyskinesia? How long before it started working for you?
OREOLU profile image
OREOLU
in Cure Parkinson's

ARE YOU A NON TREMOR DOMINANT PD PATIENT WITH DYSKINESIA? IF SO, PLEASE HELP.

What have you tried to alleviate your dyskinesia? I am YOPD patient. Your replies would be appreciated.
What have you tried to alleviate your dyskinesia? I am YOPD patient. Your replies would be appreciated.
OREOLU profile image
OREOLU
in Cure Parkinson's

Carbadopa/Levadopa

I'm experiencing some dyskinesia. How do I cut back on the levodopa-carbidopa to eliminate the dyskinesia? Thanks for your help
I'm experiencing some dyskinesia. How do I cut back on the levodopa-carbidopa to eliminate the dyskinesia? Thanks for your help
Smittybear7 profile image
Smittybear7
in Cure Parkinson's

How I went from 13 to 4 a day (Carbidopa 25/Levodopa 100)?

Also, it is widely accepted that there is a multitude of side effects of Carbidopa /Levodopa, one being dyskinesia. Revised and reposted...
Also, it is widely accepted that there is a multitude of side effects of Carbidopa /Levodopa, one being dyskinesia. Revised and reposted...
Gcf51 profile image
Gcf51
in Cure Parkinson's

How I went from 13 to 4 a day (Carbidopa 25/Levodopa 100)?

Also, it is widely accepted that there is a multitude of side effects of Carbidopa /Levodopa, one being dyskinesia.
Also, it is widely accepted that there is a multitude of side effects of Carbidopa /Levodopa, one being dyskinesia.
Gcf51 profile image
Gcf51
in Cure Parkinson's

Rytary vs sinemet

I am experiencing increased dyskinesia on Rytary. I was expecting it to decrease. Anyone else have this issue?
I am experiencing increased dyskinesia on Rytary. I was expecting it to decrease. Anyone else have this issue?
luckyrock profile image
luckyrock
in Cure Parkinson's

Tardive dyskinesia

Does anyone else suffer from this? #askingforafriend How do you best cope? I've found that Benadryl and Melatonin help. I've failed at other meds for the treatment of TD. My eyes go straight up and it's awful. My doc is trying to get Ingrezza approved for me. 🤞
Does anyone else suffer from this? #askingforafriend How do you best cope? I've found that Benadryl and Melatonin help. I've failed at other meds for the treatment of TD. My eyes go straight up and it's awful. My doc is trying to get Ingrezza approved for me. 🤞
appreciatetheleaves profile image
appreciatetheleaves
in Anxiety and Depression Support

Off peak dyskinesia

I am looking for articles on off peak dyskinesia written by a pwp, I tried keeping it forwarding it to my inbox but it didn’t arrive I’m not sure which website it was Just wonder remember it
I am looking for articles on off peak dyskinesia written by a pwp, I tried keeping it forwarding it to my inbox but it didn’t arrive I’m not sure which website it was Just wonder remember it
Connie18 profile image
Connie18
in Cure Parkinson's

The first participant has been recruited to a pioneering clinical trial which is testing a new drug called NLX-112 to reduce dyskinesia

https://www.parkinsons.org.uk/news/clinical-trial-new-dyskinesia-drug-starts-sweden
https://www.parkinsons.org.uk/news/clinical-trial-new-dyskinesia-drug-starts-sweden
nedim profile image
nedim
in Cure Parkinson's

What improvements can we anticipate within 10-15 years?

Meds to reduce dyskinesia are being trialed according to MJFF. If dyskinesia can be mitigated that would be a big improvement. A better understanding of the gut biome will hopefully lead to improved dietary recommendations. What are your thoughts?
Meds to reduce dyskinesia are being trialed according to MJFF. If dyskinesia can be mitigated that would be a big improvement. A better understanding of the gut biome will hopefully lead to improved dietary recommendations. What are your thoughts?
Hidden profile image
Hidden
in Cure Parkinson's

MRigFUS in Switzerland - 9 months update

So more in detail, my left side keeps going very well, almost no tremor, no dyskinesia on both sides, urinary urgency came back a bit, softer voice and a bit messy speech, choke more frequently, doing small manual work is still hard, but i drill holes in the ceiling in the top of a stair, brakidnesia
So more in detail, my left side keeps going very well, almost no tremor, no dyskinesia on both sides, urinary urgency came back a bit, softer voice and a bit messy speech, choke more frequently, doing small manual work is still hard, but i drill holes in the ceiling in the top of a stair, brakidnesia
Markbit profile image
Markbit
in Cure Parkinson's

Treatment with amantadine delays L-dopa-induced dyskinesia onset more than treatment with other symptomatic agents

Could early treatment with amantadine delay L-dopa-induced dyskinesia onset more than treatment with other symptomatic agents (anticholinergics or MAO-B inhibitors)?
Could early treatment with amantadine delay L-dopa-induced dyskinesia onset more than treatment with other symptomatic agents (anticholinergics or MAO-B inhibitors)?
nedim profile image
nedim
in Cure Parkinson's

Levodopa =? Dyskinesia

I take levodopa (2 pills x 200 mg throughout the day) to turn me on. Also it helps to reduce my arm's tremor. It does help, but also brings involuntary movements, even hyperactivity I'd say. Mostly it's my upper body (like I'm dancing or something). And it seems as such a waste of life energy. Is there
I take levodopa (2 pills x 200 mg throughout the day) to turn me on. Also it helps to reduce my arm's tremor. It does help, but also brings involuntary movements, even hyperactivity I'd say. Mostly it's my upper body (like I'm dancing or something). And it seems as such a waste of life energy. Is there
b-erec profile image
b-erec
in Cure Parkinson's
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