J. Eric Ahlskog, PHD, MD
Professor of Neurology at the Mayo Medical School
Chair of the Mayo Section of Movement Disorders, Mayo Clinic
More than 30 years of treating patients with Parkinson’s disease
Per Dr. Ahlskog’s book he authored: “Often, insomnia is experienced when PD is not well controlled; the restlessness and discomfort of Parkinson’s are incompatible with relaxation necessary for sleep. To those taking three Carbidopa/Levodopa doses daily, the long interval from the last dose before supper until bedtime may be the cause. Adding a fourth full dose about an hour before bedtime usually solves this problem. Note that the dose should be the same as that used during the daytime. Restated, this should be the Carbidopa/Levodopa dose identified as optimal; the sleep benefit requires a full dose. Another dose may be taken upon awakening in the middle of the night, if necessary to sustain sleep.”
Full optimal dose, two 100 mg tablets for a total of 200 mg.
To those taking three doses of C/L daily that would be 600 mg per day.
Plus the fourth full dose about an hour before bedtime, which would be 800 mg per day.
Another dose may be taken in the middle of the night, which would be a total of 1,000 mg.
Full optimal dose, three 100 mg tablets for a total of 300 mg
To those taking three doses of C/L that would be 900 mg per day.
Plus the forth full dose about an hour before bedtime, which would be 1,200 mg per day.
Another dose may be taken in the middle of the night, which would be 1,500 mg per day.
Here we have Mayo Clinic at 1,500 mg per day.
Roy Propsner seeks 1,500-1,600 mg per day with the INTENTION of working that dosage lower every week, with the outcome being the optimal dosage to prevent paralysis.