Nausea with Azilect (rasagiline)

[Snoopy5]

Hwp started Azilect a week ago and is quite nauseous from the med. Does the nausea get better with time? Have you found ways to mitigate this side effect that worked for you? Thank you in advance!

[Hidden]

did you start with a low dose?

[Snoopy5 in reply to Hidden]

Yes, taking 0.5mg daily

[Hidden in reply to Snoopy5]

I started with 0.25 the first week, 0.5 the second...only side effect I noticed was sleepiness. It went away after few weeks.

[Snoopy5 in reply to Hidden]

Thank you for your response! Good to hear you tolerated it well.

[park_bear]

MAO-B inhibitors such as Azilect only have a modest effect anyway. Not worth suffering a lot of adverse effect for the amount of benefit in my opinion.

[Snoopy5 in reply to park_bear]

Besides HDT, this is his first prescribed med as a newly diagnosed. Will give it a good try and observe any benefits or lack thereof. Appreciate your input.

[Yaya29]

I switched the azilect to pm dosage before bed for a while until I was able to tolerate it.This worked for me

[Snoopy5 in reply to Yaya29]

Thank you - switched to pm dosing last night and he had less nausea today.

[alaynedellow]

i take azilect with no issue but when i hv unbranded rsgasilene i am nauseous. The coating is different

[Lbi1608]

I threw up the first time I took it(in the morning). Started to take it in the night with no problem. I agree with park bear I am not sure it’s worth the limited benefit if you continue to experience nausea

[amykp]

Just a thought...rasagaline is a targeted MAO-B inhibitor which means you aren't supposed to have to watch what you eat, but, if you eat tons and tons of fermented foods (or something else with tyramine in it. A supplement?) I've heard it could theoretically cause a problem.

Super aged cheese? Kimchi? Just wondering...

[jaycees]

I felt quite sick, especially in the morning after I first took Azilect. The nausea never went away and my daughter suggests I take a anti nausea drug with it (like people who have cancer). I talk to my neuro and he gave me a prescription for it. I took it and the nausea stopped. For me, Azliect did not do a great deal in treating my PD - I still need a fair amount of levodopar but it seems to provide a basis and helps to smooth out the fluctuations. About 2 years later it was substituted by another drug by my neuro by a similar but newer drug called Xadago. I had no problem commencing on this new drug.