Hysteroscopy and NK cell test

[Jam1111111]

I'm back for more advice or to hear people experience of a hysteroscopy and nk cell test.

The clinc is abroad and I would be under general anesthesia for the hysteroscopy which kind of scares me a little but I've seen people say it's painful with out.

I have had a few detailed scans of my uterus and they have alway been seen as fine with no cysts, scar tissue etc.

Really undecided if this would make a difference? Had 4 embryo transfers one miscarriage and three failed transfer.

Thanks in advance x

[Endofitall]

Hi there. Have there been any lining issues or is it recurrent implantation failure?

I had a hysteroscopy when my lining just wouldn’t thicken in FETs, I think I’d had 3 failed transfers at that point as well in fresh cycles. I had it done awake and it was actually okay I think I found the endometrial biopsy (I’ve had two of these - the endoTRIOME, and NK cell) more painful but they are all over with quickly. I think the thing I would be worried about abroad is travel insurance if having investigations under GA and anything, though massively unlikely, happens. Make sure you’re covered if you go ahead.

From whether it makes any difference - I guess it’s that thing if leaving no stone unturned. My result was normal but it did mean we went back in to treatment with confidence that while me lining was thin it looked healthy and normal. Ironically since then it’s tended to be better though I’ve not had FETs.

Did you have any surgical management of miscarriage? This can make adhesions that aren’t seen on other tests sometimes. Also I do know of people who has normal scans but small septum etc found on hysteroscopy so it is the gold standard.

Wishing you luck in making a decision x

[Jam1111111 in reply to Endofitall]

Thank you for taking time to reply.

I never actually even thought about travel insurance issues so that's noted incase I do go ahead.

My lining is alway triple lined and been told it looks great, so this is more for repeated implant failures, the dr suggested these test incase the uterus is a hostile environment 🤣

They did say its up to us if we want to have these tests it's just more options to consider.

I had no surgical involvement in the miscarriage I did have to take some medication for it to come away and it showed a postive pregnancy test for 3 weeks after but I had a number of scans and blood tests in the weeks after and showed that there was nothing there and no damage to the lining.

X

[Cridog]

Hi, I recently had a hysteroscopy done at a clinic abroad with general anaesthesia. We had a failed fresh transfer last year and the clinic in the UK suggested no further investigations unless there will be 3 failed implantations, so we decided to go abroad for further investigations. The hysteroscopy went well (some pain afterwards, but managed with paracetamol, and some expected bleeding). They discovered my left tube is fully blocked (for my most active ovary), so our diagnosis of "unexplained infertility" that the UK clinic gave us is more "uninvestigated infertility"!

I haven't had travel insurance, but I thought about getting one in the rare case something went wrong.

We're expecting some more results (including for hostile environment), but I think the hysteroscopy can really help the IVF team take some extra steps to help with the implantation.

Good luck and hope you'll have get some answers and some positive results!!!

[Jam1111111 in reply to Cridog]

Thank you for the reply.

I've had much right tub removed in 2009 as it wS twisted. We have done icsi in every occasion and we did get implantation with cycle although ended in miscarriage so I'm kind of on the fence about wither it's worth doing as I feel it implanted one why not again but the same time I'm thinking why isn't it implanting lol x

[Rcs11]

hi, I had a hysteroscopy without any anaesthesia & I will never do it again, so painful! Take the GA! Or could they do it under sedation like we use for egg collection here?

As for hostile environment , have you used probiotics? That was advised to me after Alice/Emma.

Interesting re: blocked tube, I’ve never had my tubes scanned but I have an appt to discuss this if the current FET round I’m in fails xx

[Conceivingblee]

100% get the hysteroscopy this us what got got me my reason for 'unexplained infertility' it certainly wasn't un explained and would have saved 10s of thousands of pounds, huge trauma and alot of heartache. Had several abroad whilst they tried to mend my womb. And all was good Good luck xxxx

[Jam1111111 in reply to Conceivingblee]

Thanks that's what I'm think we have all ready spent several tens of thousands and I'm so undecided although I feel abroad its less about how much money they can make from you x

[Conceivingblee in reply to Jam1111111]

Categorically the care you get abroad is better and they want you to have a baby not just take your cash. I think they investigate more and are more willing to to explore supportive methods. Deffo cheaper abroad for this procedure than in UK aswellxx

[Spaghetti85]

I had also a hysteroscopy done abroad before any transfer and I wish that had been my first test ever done. I didn't have GA, only a muscle relaxant tablet 2h before, and for me it was a bit painful during the biopsy itself but I was able to manage with just paracetamol and a hot water bottle afterwards. We finally understood fully our "unexplained infertility" in UK was actually chronic endometritis which after 2 weeks of antibiotics was cleared. Two months later we did our first FET transfer and it worked. I wonder sometimes if just having known I had CE and treated it before the rest of the IVF process could have saved us from actually doing the IVF cycle...

[Jam1111111 in reply to Spaghetti85]

Thank you for the reply.

Yeah im really on the fence with it at the minute part of me thinks one implanted before and other part of me think we come so far maybe we should test again money plays apart as the clinc would want two trips one for the hysteroscopy and the other for transfer so again I'm unsure x

[Spicycurry]

The endometrial biopsy is valuable. It tells you if your nk cells in endometrium, not blood, are low, ok or high. If low nk cells in endometrium, it can prevent implantation. You can get treatment for this such as neupogen infusion or hcg infusion on transfer day.

[Jam1111111 in reply to Spicycurry]

Thanks for the reply I know ot could prove valuable just looking to hear other people's response and experience

[Spicycurry in reply to Jam1111111]

I have tested for low nk cells in endometrium. I have had treatment for it for a frozen transfer and implantation has worked.

[Leii9]

Hi, i had a hysteroscopy, and they found that i have a chronic inflammation, so i took antibiotics before each transfer after that. I now have a beautiful 4 months old daughter. X

[Jam1111111 in reply to Leii9]

Thanks it defo something me to consider I think x

[MontsJ]

I’d love if yuu wouldn’t mind PM’ing me which clinic you are with to be having biopsy for NK cell testing. Most clinics here do blood testing and I am unclear about the pros and cons of both

[Batsford]

Hi Jam, I had a normal test result for NKC in a uterine hysteroscopy a few years ago, but an abnormal NKC blood test subsequently. The private miscarriage clinic which treated me successfully this year, said that the uterine sample test is inaccurate and outdated and that the only accurate test is the blood test. I’m not sure of the reason behind this but that’s what they explained to me. Best of luck.

[Jam1111111 in reply to Batsford]

Thank you for replying. That something for me to look into. Thanks xx