DE failure: Our 5 th rounds has failed... - Fertility Network UK

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DE failure

Conceivingblee profile image
13 Replies

Our 5 th rounds has failed used DE this time. I don't know where to turn now. What else can I try.

I was on on 12 mg oestradiol 120mg Utrogestan and prontogest every 72 hours.

Inhixa.

Used the results from ERA treated the bacterial infection my womb had from the EMMA result.

What else is there I can do to help us get the child we want.

Is there anything I'm missing?

Advice please 😭😔

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Conceivingblee profile image
Conceivingblee
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13 Replies
Bomboncita profile image
Bomboncita

Oh I'm do sorry sweetie that you are going through this. Have you considered changing clinics? May I ask in which country you are doing the treatment? There are good places out there for these kind of treatments. Sending you lots of love.

Conceivingblee profile image
Conceivingblee in reply to Bomboncita

I'm in the UK. Using a clinic in Notts.Yes I've thought about changing but limited in the area for nearish clinics.

This one's already 80 mins away from me

Bomboncita profile image
Bomboncita in reply to Conceivingblee

Have you considered going to Spain?

Conceivingblee profile image
Conceivingblee in reply to Bomboncita

Abroads difficult due to our jobs and not having the flexibility to take enough time off

Bomboncita profile image
Bomboncita in reply to Conceivingblee

I'm sorry to hear that. There must be a way. Sending you hugs.

Nevergu profile image
Nevergu

Was the embryo tested? Even DE can be abnormal. Also, have you had any immune testing? It's possible your body is rejecting embryos.

Conceivingblee profile image
Conceivingblee in reply to Nevergu

No as we only got on so no point really all the other eggs died in the thawing process so I have an investigation ongoing at the clinic as that shouldn't of happened. I have had all level one tests buy not ones for NK I'm on blood thinners for lupus anticoagulation activity which was diagnosed during those tests.

Nevergu profile image
Nevergu in reply to Conceivingblee

I'm sorry to hear that. It seems there is an issue with their processes/lab unless the embryos were poorly graded which would suggest a potential sperm/egg issue. We tested 3 DE embryos, 2 were euploid and 1 was segmental( not reccomended for transfer due to chromosome involved). Ours was a proven donor. We were dissapointed to only get 3 blasts from 12 eggs but after hearing your story I think we did reasonably OK.

In preparation for transfer I have done nk cells, clotting and full thyroid panel tests. I was found to have thyroid antibodies and slightly raised nk cells so will be on a heavy immune protocol for that in addition to clexane starting before transfer. I also had hysteroscopy as I had 2 x natural miscarriages and haven't been able to get pregnant naturally or with OE since. No issues were found with my uterus.

I would suggest more testing and maybe pgt if you get enough embryos. I agree if you only get one it's probably not worth it but transfers cost money plus the emotional side of things which you can't put a value on. I would also look at other clinics as loosing embryos in thawing process would worry me. I'm travelling abroad for mine, inconvenience it's a small price to pay in the whole process. Best of luck x

Conceivingblee profile image
Conceivingblee in reply to Nevergu

Hey Nevergu. I'm deffo gonna push for them to put me on prednisolone I think next time . I'm waiting the outcome of my complaint to the egg donor bank. I'm hoping they are kind enough to give us another set. But I think I will have to fight. I wish you luck with you cycle. Thankyou for your testing advice.

Boo718 profile image
Boo718

Hiya we had a double donor round got 3 fantastic blasts …. All 3 were abnormal when we pgd checked them.

Did you check that the bacteria levels had got better?

I am on blood thinners and prednisolone a steroid I wonder if they might help you xxx

Conceivingblee profile image
Conceivingblee in reply to Boo718

Hey Boo My clinic refused prednisolone this round even though I asked. I think I'm going push for it if we have another go.

My bacteria levels had pretty much resolved after the first round of antibs so the second round should of sorted them right out. I decided not to opt for a 3rd biopsy as felt that it wasn't necessary.

I'm sorry to here your 3 blasts were no good. What happens in that situation does your clinic let you go again?

Boo718 profile image
Boo718 in reply to Conceivingblee

Yeh our clinic were amazing. It was just pure bad luck as both the donors were vetted and the embryos were 5aa. So we got another round. I always thought moving to donor would be a definate but it’s not. We are heading in sep for our 4th double donor transfer after one bfn and two chemicals. There’s always a hurdle. I’m on progyluton, aspirin, prolutex, prednisolone, and clexane. Next time we are going to check progesterone in the tww and hopefully up the prednisolone. I hope you get your wee miracle soon xxx

Conceivingblee profile image
Conceivingblee in reply to Boo718

That's really good to hear. It's nice to hear a clinic that is supportive to often it's just about money isn't it. I'm hoping mine sees that the face that 5 of the eggs didn't survive thaw isn't acceptable but who knows.Totally agree that Donor was pretty much the only solution my clinic have me from cycle 3 then in a 5 th cycle where I come to terms with it this happens

I hope you also get your miracle

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