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ESMO 2024: Phase 3 evaluation of transdermal estradiol vs LHRH agonists for androgen suppression
Results demonstrated that transdermal
estradiol
was non-inferior to LHRH agonists, with metastasis-free survival rates of 86% and 87%, respectively. Overall survival slightly favored the
estradiol
group (hazard ratio 0.89), although this was not statistically significant.
Results demonstrated that transdermal
estradiol
was non-inferior to LHRH agonists, with metastasis-free survival rates of 86% and 87%, respectively. Overall survival slightly favored the
estradiol
group (hazard ratio 0.89), although this was not statistically significant.
Maxone73
in
Advanced Prostate Cancer
2 days ago
Building Bones and Shrinking Moobs
Started transdermal
estradiol
(0.0375 mg) in November 2023 to counter negative effects of ADT (relugolix and abiraterone) on bone density. Increased the
estradiol
to 0.075 mg in January 2024 which accelerated my gynecomastia.
Started transdermal
estradiol
(0.0375 mg) in November 2023 to counter negative effects of ADT (relugolix and abiraterone) on bone density. Increased the
estradiol
to 0.075 mg in January 2024 which accelerated my gynecomastia.
Flydad
in
Advanced Prostate Cancer
2 months ago
Estradiol patches
Does anyone have any experience with
estradiol
patches? For my previous FET I was only on tablets, but this time they've also added 2 patches that need changing every 48 hours. where do you stick them?
Does anyone have any experience with
estradiol
patches? For my previous FET I was only on tablets, but this time they've also added 2 patches that need changing every 48 hours. where do you stick them?
Connie290
in
Fertility Network UK
2 months ago
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Cancelled cycle due to bad response
She wants to use
estradiol
patches for her new cycle. Has anyone experienced similar issue, and what are your thoughts about
estradiol
patches.Thanks in advance, every thought counts
She wants to use
estradiol
patches for her new cycle. Has anyone experienced similar issue, and what are your thoughts about
estradiol
patches.Thanks in advance, every thought counts
Mounamilou
in
Fertility Network UK
1 month ago
Estradiol Patch
Hi Everyone My husband (diagnosed November 2013 see bio ) November 2023 prescribed 2nd generation Xtandi as Zoladex injections became castrate resistent, he has no mets. The full dose became intolerable so Onc lowered it to 2 x 80mg, things were going ok psa was dropping good, then started to slow
Hi Everyone My husband (diagnosed November 2013 see bio ) November 2023 prescribed 2nd generation Xtandi as Zoladex injections became castrate resistent, he has no mets. The full dose became intolerable so Onc lowered it to 2 x 80mg, things were going ok psa was dropping good, then started to slow
Knittingque
in
Advanced Prostate Cancer
3 months ago
CRPC and low dose Estradiol patch
Can anyone tell me if being Crpc and doing low dose
estradiol
have a negative effect on psa
Can anyone tell me if being Crpc and doing low dose
estradiol
have a negative effect on psa
Knittingque
in
Advanced Prostate Cancer
2 months ago
Estrogen content for bone health
Got check for
Estradiol
in blood which showed 36.5pg. Is it possible with such low T levels following Orchidectomy that
Estradiol
would be so high?
Got check for
Estradiol
in blood which showed 36.5pg. Is it possible with such low T levels following Orchidectomy that
Estradiol
would be so high?
binati
in
Advanced Prostate Cancer
5 days ago
estradiol cream
I know this was discussed 8 years ago but has it changed for the better regarding reducing the ADT SE? I am on ADT for 2 + years and going on Xtandti this month. I want to control the SE as best I can. Great diet and heavy exercise every day. Also stopped the Vit Cal & D.
I know this was discussed 8 years ago but has it changed for the better regarding reducing the ADT SE? I am on ADT for 2 + years and going on Xtandti this month. I want to control the SE as best I can. Great diet and heavy exercise every day. Also stopped the Vit Cal & D.
Stevegr
in
Advanced Prostate Cancer
5 months ago
pcos or perimenopause. Pleaseee help me.
My
estradiol
level is low. I don’t understand anything anymore. Have I officially entered perimenopause, or is this problem caused by PCOS? I can’t figure out if the long menstruations are due to a lack of
estradiol
or progesterone.
My
estradiol
level is low. I don’t understand anything anymore. Have I officially entered perimenopause, or is this problem caused by PCOS? I can’t figure out if the long menstruations are due to a lack of
estradiol
or progesterone.
Jenisa
in
Fertility Network UK
3 months ago
Estrogens and Castrate/Treatment Resistance?
Has anyone using estrogens (
estradiol
) as the primary agent of ADT (androgen deprivation therapy) had their prostate cancer become resistant (androgen independent) to the treatment?
Has anyone using estrogens (
estradiol
) as the primary agent of ADT (androgen deprivation therapy) had their prostate cancer become resistant (androgen independent) to the treatment?
Lost_Sheep
in
Advanced Prostate Cancer
3 months ago
8dp 5dt negative test
Hi, Im 8 days passed a 5 day blastocyst transfer, the issues we had were with my partner and not myself, and getting 2 good grade embryos was amazing however this is the first FET i have no symptoms and still negative at 8dpt taking
estradiol
, blood thinners and progesterone pessaries and lubion, anyone
Hi, Im 8 days passed a 5 day blastocyst transfer, the issues we had were with my partner and not myself, and getting 2 good grade embryos was amazing however this is the first FET i have no symptoms and still negative at 8dpt taking
estradiol
, blood thinners and progesterone pessaries and lubion, anyone
Impatientivfwarrior
in
Fertility Network UK
3 months ago
Bleeding 6 days before planned FET
I had a lot of issues with thin lining in my previous FET, ended up increasing
estradiol
to 10mg and introducing patches. My lining still only just got to 7mm and we transferred really late in the cycle (something like CD32).
I had a lot of issues with thin lining in my previous FET, ended up increasing
estradiol
to 10mg and introducing patches. My lining still only just got to 7mm and we transferred really late in the cycle (something like CD32).
Someday_Bluesky
in
Fertility Network UK
13 days ago
Fet ultrasounds and checkup?
I started
estradiol
2/day (6mg) and am also doing an immune protocol with 10mg prednisone and 150mg baby aspirin. They advised me to come in for an ultrasound at cd14 to check lining but that seems late...especially bc my cycles have been shorter lately. Should I be going in earlier?
I started
estradiol
2/day (6mg) and am also doing an immune protocol with 10mg prednisone and 150mg baby aspirin. They advised me to come in for an ultrasound at cd14 to check lining but that seems late...especially bc my cycles have been shorter lately. Should I be going in earlier?
Norregirl
in
Fertility Network UK
2 months ago
Hunger on FET cycle
I’ve just started my first ever FET cycle and it’s currently day 5 of the
estradiol
tablets. Anyone else on a FET cycle now? Since the 2nd day I’ve been so incredibly hungry all the time! I eat and then an hour later I’m STARVING again where normally I could go without eating for 4-5 hours.
I’ve just started my first ever FET cycle and it’s currently day 5 of the
estradiol
tablets. Anyone else on a FET cycle now? Since the 2nd day I’ve been so incredibly hungry all the time! I eat and then an hour later I’m STARVING again where normally I could go without eating for 4-5 hours.
Peppik
in
Fertility Network UK
19 days ago
Estradiol level before frozen transfer
Hi there My
estradiol
level before starting poi today is 1000. Is it too high for a frozen transfer? I’ve read somewhere that more than 500 would negatively affect implantation. My doctor isn’t concerned about it but I need some reassurance please 🙏🏻
Hi there My
estradiol
level before starting poi today is 1000. Is it too high for a frozen transfer? I’ve read somewhere that more than 500 would negatively affect implantation. My doctor isn’t concerned about it but I need some reassurance please 🙏🏻
amalhope
in
Fertility Network UK
5 months ago
Some advice on new lab results please
estradiol
: 110 ng/L progesteron: 9.13 microgram/L LH: 11.7 U/L FSH: 7.9 U/L (I am not on HRT)
estradiol
: 110 ng/L progesteron: 9.13 microgram/L LH: 11.7 U/L FSH: 7.9 U/L (I am not on HRT)
Sofie007
in
Menopause and Perimenopause Support
5 months ago
Cerotto Estradiol e terapia ormonale sostitutiva in vacanza
Ciao a tutti, vi seguo da molto tempo ma questo è il mio primo post. Ho terminato la terapia di 2 anni con ADT ad agosto e mentre aspetto che il testosterone si riprenda mi chiedevo se qualcuno ha continuato dopo ADT a prendere cerotti di estradiolo (25 mcg 2 volte a settimana) per le ossa fino al recupero
Ciao a tutti, vi seguo da molto tempo ma questo è il mio primo post. Ho terminato la terapia di 2 anni con ADT ad agosto e mentre aspetto che il testosterone si riprenda mi chiedevo se qualcuno ha continuato dopo ADT a prendere cerotti di estradiolo (25 mcg 2 volte a settimana) per le ossa fino al recupero
giorgioc
in
Advanced Prostate Cancer
5 days ago
Location of Estrogen Patches matters.
Overall, the average serum
estradiol
concentration is
3-4 times
higher for scrotal application, compared to forearm application. This is particularly relevant to estrogen users who use gel, cream, or spray products. Ref: transfemscience.org
Overall, the average serum
estradiol
concentration is
3-4 times
higher for scrotal application, compared to forearm application. This is particularly relevant to estrogen users who use gel, cream, or spray products. Ref: transfemscience.org
janebob99
in
Prostate Cancer Network
6 months ago
Estradiol, QoL and inflammation
Did
estradiol
play a role? I obviously want to avoid endangering the course of treatment. As a high CRP can only lead to nasty consequences, I hope to be able to rule out a possible role of
estradiol
(and then find the real cause) before moving further down that road.
Did
estradiol
play a role? I obviously want to avoid endangering the course of treatment. As a high CRP can only lead to nasty consequences, I hope to be able to rule out a possible role of
estradiol
(and then find the real cause) before moving further down that road.
Cliff-hanger
in
Advanced Prostate Cancer
7 months ago
Massive hairloss & anxiety -blood results help
Sweaty hands, very frequent bowel movement Tsh 1.7 (0.27-4.2) ft4 17.6 (12-22) ft3 4.59 (3.10-6.8) iron 112 (40-150) ferritine 50 (15-150) transferritine 2.3 (2-4) saturation 35% (16-45) LH 11.7 (1-11.4) FSH 7.9 (1.7-7.7)
estradiol
110 (33-298) progesterone 9.13 (1.8-23.9) Vit D 30 (20-
Sweaty hands, very frequent bowel movement Tsh 1.7 (0.27-4.2) ft4 17.6 (12-22) ft3 4.59 (3.10-6.8) iron 112 (40-150) ferritine 50 (15-150) transferritine 2.3 (2-4) saturation 35% (16-45) LH 11.7 (1-11.4) FSH 7.9 (1.7-7.7)
estradiol
110 (33-298) progesterone 9.13 (1.8-23.9) Vit D 30 (20-
Sofie007
in
Thyroid UK
5 months ago
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