I have stage 4 endo, diagnosed after 20 years. Since then I've had 4 surgeries, the most recent one being a bowel resection and an ileostomy in December which has since been reversed. Each time I have surgery I'm given a Zoladex shot for 6 months with HRT. With no period and no excruciating and debilitating pain, my life is wonderfully different with zoladex. I would happily continue with Zoladex as I'm prepared to do just about anything to make the pain go away. I would like to know if anyone has been on Zoladex for more than 6 months and what the possible down side is. Any advice is welcome. I'm 35 years.