Appreciate any thoughts on this as I am trying to perfect a PD vitamin cocktail Here is what I have come up with so far:
TRU Niagen 250 mg / day, Pterostilbene 100 mg / day (Pterostilbene 20 times more bioavailable than resveratrol and stays in the blood 7 times longer but has the same impact on cellular function…); 2 grams a day of thiamine hcl (1 for breakfast and 1 for lunch) and a B multi vitamin. 600 NAC 2 x day, Fish Oil capsule, Add a tsp Mannitol to coffee because I will wash all this down with 2 cups of coffee (LOL).
My meds (for those who may be interested) Azilect, 1 Ropinirole at night. Exercise.
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p-oui
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P-oui may i suggest separating your b1 and caffeine? Caffeine blocks absorbtion of b1. Dr Costantini suggests one cup of coffee is ok at least an hour or hour and a half before the thiamine.
I have a disease far more virulent than PD. I graduated Magna Cum Laude from one of the top universities (Dartmouth College) with a degree in Engineering (not easy and science based). I have STOPPED the progression of my disease and reversed my symptoms. Who above has done that.
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1) You do NOT need to take a B complex. There is zero scientific research showing a B complex is necessary to increase NAD+, but there are real human clinical trials showing Niagen ALONE increases NAD+ WITHOUT other B vitamins.
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2) Coffee will NOT significantly alter the absorption of ANY vitamin ESPECIALLY at the dose level you are considering, AND furthermore mannitol disrupts the gut and enhances absorption most likely counter acting the coffee inhibition.
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Try your own cocktail and make your own decisions. Don't listen to ANY of US quacks online and that includes me. The vast majority of people who post on this website have a severe lack of scientific background and believe most of what they read online.
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Research on your own. Talk to a real doctor. Don't listen to people on this forum.
Thank you for your valuable input. I have worked in health care for almost 30 years, half of that along side neuro surgeons and neuroscientists as their interventional assistant. I have also improved significantly since one year ago when i began my supplementation regimen, which i continue to tweak as i see fit.
This is awesome news (awesome is a word used extensively by my 13 year old nephew) but I mean it! Any details on your improvement are appreciated. We are all in this together and I am so happy to hear how others are taking control of their treatment and seeing [sometimes dramatic] benefit and perhaps making important strides that can benefit all of us.
Sunvox thank you so much! I am so sorry to hear about your condition. The research environment moves so slowly in spite of advances in technology! Therefore these boards are a valuable medium to all of us and important in that we share our findings.
You give great advice and it is appreciated. I believe we should be careful, especially considering drug to drug interactions. FYI: I work with my GP on a study mirroring Cedars Sinai on Victoza / Liraglutide for several months and I see positives in my response. Also working with him on slowly beginning Isradipine. Otherwise I take Azilect. I am considering Amantadine for cramping (foot) which prohibits exercise a little.
You mention one thing about mannitol. Do you take it?
I think the B complex is good for the heart (there was just an article on medpage today with that conclusion.) I think folic acid is best taken as MTHFR which is more bioavailable, especially if you have the gene that blocks uptake. The bad press is for folks that carry the gene, THEN take folic acid...and can't "use" it. I think the jury's out on thiamine and niacin, but why not?
All that being said, the life extension brand looks pretty good!
Hi Carrington, I’ve only been taking vitamin B1, thiamine, for one month as prescribed by Dr. Constantini, but I ramped up slowly. Still, I believe I see improvement in my tremor.
Looks like B2/Riboflavin may be helpful also. Here is a quote from the following study:
Riboflavin Ameliorates Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation
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Here is what I have come up with so far:
High Dose of B vitamins (B1, B2, B3 and B5) in Parkinson Disease
Why B1 needs magnesium and potassium
PD, Vitamin B1 and blood testing
Unlocking the Maze of B Complexes: A Handy List for Safe Dosages and Bioactive Vitamins
Parkinsons detox 
