What Makes a Perfect PD Vitamin Cocktail?

[p-oui]

B Vitamins are really getting my attention! B3 B1 B6 B12 and I just read a new study this morning that pterostilbene helps with B3.

I'd love to hear thoughts from the group on the assortment of B vitamins. Also, Re B1 does anyone know of trials in the U.S.?

RE B3 thoughts on Niacin vs Niagen?

A great link on the subject of B3: scienceofparkinsons.com/201...

Appreciate any thoughts on this as I am trying to perfect a PD vitamin cocktail Here is what I have come up with so far:

TRU Niagen 250 mg / day, Pterostilbene 100 mg / day (Pterostilbene 20 times more bioavailable than resveratrol and stays in the blood 7 times longer but has the same impact on cellular function…); 2 grams a day of thiamine hcl (1 for breakfast and 1 for lunch) and a B multi vitamin. 600 NAC 2 x day, Fish Oil capsule, Add a tsp Mannitol to coffee because I will wash all this down with 2 cups of coffee (LOL).

My meds (for those who may be interested) Azilect, 1 Ropinirole at night. Exercise.

[wifeofparky]

In general the B vitamins work together. I would take a high quality B Complex supplement and any special extra B's that you feel would help you

[Hidden in reply to wifeofparky]

Life Extension Bio-Active Complete B-Complex, 60 Capsules. Ingredients include 100mg thiamin HCI, 400mcg Folate, 100mg B-6

[park_bear]

Just leave out the folate because folate supplementation is carcinogenic. I wrote about that here:

Folate Supplementation Carcinogenic

tinyurl.com/ycdrz5lj

Here is a B complex without folate:

amazon.com/gp/product/B003C...

[Grumpy77 in reply to park_bear]

Can't search or read all your previous posts so briefly in lay mans language what do you mean by folate supplementation is carcinogenic?

Many thanks

[park_bear in reply to Grumpy77]

I provided a link. Click on it.

[M1tz1 in reply to park_bear]

Park_bear is folic acid also carcinogenic? I've been on it for years because I heard that it helps prevent Alzheimer's. No sign of cancer so far.

[park_bear in reply to M1tz1]

yes. see info at link.

[bassofspades]

P-oui may i suggest separating your b1 and caffeine? Caffeine blocks absorbtion of b1. Dr Costantini suggests one cup of coffee is ok at least an hour or hour and a half before the thiamine.

[sunvox]

I have a disease far more virulent than PD. I graduated Magna Cum Laude from one of the top universities (Dartmouth College) with a degree in Engineering (not easy and science based). I have STOPPED the progression of my disease and reversed my symptoms. Who above has done that.

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1) You do NOT need to take a B complex. There is zero scientific research showing a B complex is necessary to increase NAD+, but there are real human clinical trials showing Niagen ALONE increases NAD+ WITHOUT other B vitamins.

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2) Coffee will NOT significantly alter the absorption of ANY vitamin ESPECIALLY at the dose level you are considering, AND furthermore mannitol disrupts the gut and enhances absorption most likely counter acting the coffee inhibition.

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Try your own cocktail and make your own decisions. Don't listen to ANY of US quacks online and that includes me. The vast majority of people who post on this website have a severe lack of scientific background and believe most of what they read online.

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Research on your own. Talk to a real doctor. Don't listen to people on this forum.

[bassofspades in reply to sunvox]

Thank you for your valuable input. I have worked in health care for almost 30 years, half of that along side neuro surgeons and neuroscientists as their interventional assistant. I have also improved significantly since one year ago when i began my supplementation regimen, which i continue to tweak as i see fit.

[p-oui in reply to bassofspades]

This is awesome news (awesome is a word used extensively by my 13 year old nephew) but I mean it! Any details on your improvement are appreciated. We are all in this together and I am so happy to hear how others are taking control of their treatment and seeing [sometimes dramatic] benefit and perhaps making important strides that can benefit all of us.

[bassofspades in reply to p-oui]

Step 1 was firing my neurologist. Step 2 was getting on the Hinz Protocol. Step 3 was Dr Cosentini's protocol.

[bassofspades in reply to sunvox]

And Dr Costantini is a real doctor.

[Gioc in reply to sunvox]

Hi Sunvox,

lI see you've increased B1 from 400mg to 1000mg at day just a few months ago in your protocol. It's correct?

[p-oui in reply to sunvox]

Sunvox thank you so much! I am so sorry to hear about your condition. The research environment moves so slowly in spite of advances in technology! Therefore these boards are a valuable medium to all of us and important in that we share our findings.

You give great advice and it is appreciated. I believe we should be careful, especially considering drug to drug interactions. FYI: I work with my GP on a study mirroring Cedars Sinai on Victoza / Liraglutide for several months and I see positives in my response. Also working with him on slowly beginning Isradipine. Otherwise I take Azilect. I am considering Amantadine for cramping (foot) which prohibits exercise a little.

You mention one thing about mannitol. Do you take it?

[amykp]

I think the B complex is good for the heart (there was just an article on medpage today with that conclusion.) I think folic acid is best taken as MTHFR which is more bioavailable, especially if you have the gene that blocks uptake. The bad press is for folks that carry the gene, THEN take folic acid...and can't "use" it. I think the jury's out on thiamine and niacin, but why not?

All that being said, the life extension brand looks pretty good!

[KERRINGTON]

Hi...does this recipe help restore dexterity, and reduce tremors ?

[p-oui]

Hi Carrington, I’ve only been taking vitamin B1, thiamine, for one month as prescribed by Dr. Constantini, but I ramped up slowly. Still, I believe I see improvement in my tremor.

[Hidden]

Looks like B2/Riboflavin may be helpful also. Here is a quote from the following study:

Riboflavin Ameliorates Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pubmed/145...

nature.com/articles/srep45861

Art