Has anyone tried or possess any information about using D-serine?

[glassman1]

I came across some interesting research and wondered if anyone had tried this therapy. cuimc.columbia.edu/news/can...

[park_bear]

The study referenced in this article:

D-serine adjuvant treatment alleviates behavioural and motor symptoms in Parkinson’s disease

academic.oup.com/ijnp/artic...

Subjects were randomly allocated to receive either DSR or placebo for 6 wk, 30 mg per kilogram daily according to the following particulars:

"Experimental treatment was initiated at a 10 mg/kg.d dose and was increased after the first and second weeks of treatment to 20 mg/kg.d and a fixed 30 mg/kg.d dose, respectively. The range of fixed absolute daily DSR doses was 1.6–2.6 g (mean¡S. D., 2.0¡0.3 g). Daily experimental treatment was administered in three divided doses."

After 6 weeks UPDRS improved by 8.6 points in the treatment arm, versus two points in the placebo arm. Impressive.

Appears to be safe at this dose: frontiersin.org/articles/10...

I had been unaware of this and got some on order immediately. the only vendor I could find was this one: amazon.com/dp/B09TWCN545

There are lots of sources of L-serine and phosphatidyl serine, but these are not the same.

[fnedorez70 in reply to park_bear]

Please keep us posted on your progress if possible In the past treatment with amino acids wasn't particularly effective but who knows this one might be different. I didn’t see a good explanation for the mechanism of this replacement. The subjects maintained their regular Parkinson medication regiment . So it is possible that this is the way to increase absorption of ldopa. No reported dyskinesia although.

[park_bear in reply to fnedorez70]

Participants in the trial experienced slow and steady improvement which is characteristic of disease modification. Symptomatic improvement due to increased availability of dopamine is usually quite rapid. You can be sure that if I experience improvement due to this intervention I will report on it.

[fnedorez70 in reply to park_bear]

You know, I noticed that publication in Israel is quite old: 2011. I think if there was a noticeable improvement in pd we would have heard about it by now

[park_bear in reply to fnedorez70]

Not patentable, so no profit-seeking biotech was interested.

There was a noticeable improvement as reported by the study. If anybody had studied it since and found to the contrary, it would have been reported accordingly.

Be that as it may, no one is requiring you to try it.

[fnedorez70 in reply to park_bear]

I agree. I did a search on serine on this site and it came up with one cautionary post that Alzheimer's disease could be caused by serine supplements.

[Biscuit61 in reply to park_bear]

Hi Parkbear my partner weighs 43 kilograms so can you help me understand how much of this supplement she should take daily?

Thanks in advance

[park_bear in reply to Biscuit61]

Multiply the number of kilograms, which is 43, by the number of milligrams per kilogram specified, which is 10, 20, and 30, respectively for the first, second and subsequent weeks, to arrive at the daily dose.

[glassman1 in reply to park_bear]

Thanks PB, my order arrives today. I will keep you posted

[popo1 in reply to park_bear]

amazon.com/stores/Relentles...

same here, ordered some as soon as i did some research. excited to give it a go

[Bolt_Upright]

Study of Alzheimer’s marker prompts warning about serine supplements 2022 asbmb.org/asbmb-today/scien...

"Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease, and a study led by the University of California San Diego provides new evidence to support this claim. In analyzing brain tissue, researchers observed a trend consistent with their previous findings in blood samples: expression levels of the gene coding for PHGDH were consistently higher in adults with different stages of Alzheimer’s disease, even the early stages before cognitive symptoms manifested.

The findings also prompt caution against the use of dietary supplements that contain the amino acid serine as a remedy for Alzheimer’s disease. Because PHGDH is a key enzyme in the production of serine, the increased PHGDH expression found in Alzheimer’s patients suggests that the rate of serine production in the brain is also increased, and thus, taking additional serine may not be beneficial, the researchers warned. "

[Bolt_Upright in reply to Bolt_Upright]

"The case against serine:

The findings come with implications for serine supplements, which are advertised to improve memory and cognitive function. The key player responsible for making serine in the body is PHGDH. Some researchers have proposed that PHGDH expression is reduced in Alzheimer’s disease, and that boosting serine intake could help with treatment and prevention. Clinical trials are already underway to test serine treatments in older adults experiencing cognitive decline.

But with their data consistently showing increased PHGDH expression in Alzheimer’s, the researchers posit that serine production may likely be increased in this disease, contrary to what some other groups claim.

“Anyone looking to recommend or take serine to mitigate Alzheimer’s symptoms should exercise caution,” said co-first author Riccardo Calandrelli, who is a research associate in Zhong’s lab."

[park_bear in reply to Bolt_Upright]

I was going to note that L-serine is different from D-serine. Then I found this in the research paper referenced by your article:

cell.com/cell-metabolism/fu...

"reduction of D-serine by knocking out serine racemase, the L-serine to D-serine conversion enzyme, has a protective effect on amyloid-β toxicity in a mouse model (Inoue et al., 2008)."

What this indicates is that D-serine is so badly needed by healthy neurons that evolution has created an enzyme to convert L-serine to D-serine.

The research you have referenced makes a good case that serine is adverse in Alzheimer's. However, given this evidence that D-serine is needed by healthy neurons, and the human clinical study we have at hand that shows us that it is beneficial in Parkinson's, in my opinion the evidence favors D-serine for Parkinson's.

[Bolt_Upright]

On the other hand, from 2023: L-serine: Neurological Implications and Therapeutic Potential pmc.ncbi.nlm.nih.gov/articl...

"L-serine is a non-essential amino acid that plays a vital role in protein synthesis, cell proliferation, development, and sphingolipid formation in the central nervous system. It exerts its effects through the activation of glycine receptors and upregulation of PPAR-γ, resulting in neurotransmitter synthesis, neuroprotection, and anti-inflammatory effects. L-serine shows potential as a protective agent in various neurological diseases and neurodegenerative disorders. Deficiency of L-serine and its downstream products has been linked to severe neurological deficits. Despite its crucial role, there is limited understanding of its mechanistic production and impact on glial and neuronal cells. Most of the focus has been on D-serine, the downstream product of L-serine, which has been implicated in a wide range of neurological diseases. However, L-serine is approved by FDA for supplemental use, while D-serine is not. Hence, it is imperative that we investigate the wider effects of L-serine, particularly in relation to the pathogenesis of several neurological deficits that, in turn, lead to diseases. This review aims to explore current knowledge surrounding L-serine and its potential as a treatment for various neurological diseases and neurodegenerative disorders."

[MBAnderson in reply to Bolt_Upright]

Dave,

Would you take it if you were me?

[fnedorez70 in reply to MBAnderson]

SMarc, I would ask the doctor if I was you I printed the paper and I was going to take it when I see my neurologist next time I'm in JUNE

[Bolt_Upright in reply to MBAnderson]

Hi Marc, I have not really looked at it that closely. park_bear seems to have done the deepest dive.

If I were me I would not take it because, not to jinx myself, I still kind of think my gluten and lectin free diet with only beef as a meat and Pepsi with real sugar and limited ingredient ice cream with real sugar and a cup of pistachios a day and broccoli sprouts and my limited number of supplements and isochronic tones is working for me. It seems sacrilegious and is almost certainly wrong and dumb, but in the four years since I was diagnosed with RBD (along with some other troubling symptoms) I have done nothing but improve in almost all ways. I'm thinking I'm going to be okay.

This could just be the 30 mg of lithium orotate a day talking. I should know whether I am correct in about 10 years.

[ParkinsonsLady]

You can buy D-serine powder here:

lifelabsupplements.com/us/d...

[popo1]

amazon.com/stores/Relentles...

"D"-serine.

thanks for the post glassman1, excited to try.

[glassman1 in reply to popo1]

Started mine today, I'll keep you posted