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A study record is now available on the Clinical Trials website for the big (N=330) Ambroxol Phase 3 trial (NCT05778617)

Ambroxol to Slow Progression in Parkinson Disease (ASPro-PD): https://clinicaltrials.gov/ct2/show/NCT05778617
Ambroxol to Slow Progression in Parkinson Disease (ASPro-PD): https://clinicaltrials.gov/ct2/show/NCT05778617
jeffreyn profile image
jeffreyn
in Cure Parkinson's
2 months ago

Ambroxol and Parkinson’s

a clinical trial of ambroxol called ‘Ambroxol to Slow Progression in Parkinson’, or the ‘ASPro – PD’ trial, will begin. This is a large phase 3 clinical trial to determine if ambroxol can slow or stop Parkinson’s.
a clinical trial of ambroxol called ‘Ambroxol to Slow Progression in Parkinson’, or the ‘ASPro – PD’ trial, will begin. This is a large phase 3 clinical trial to determine if ambroxol can slow or stop Parkinson’s.
Farooqji profile image
Farooqji
in Cure Parkinson's
5 months ago

Ambroxol: Experimental treatment for PD

Does anyone know anything about the clinical trials going on in the UK with Ambroxol as a treatment for PD (a repurposed cough medicine)? The preliminary results look good. I understand that results have been released but I can't find It. Please reply if you have info. Thanks
Does anyone know anything about the clinical trials going on in the UK with Ambroxol as a treatment for PD (a repurposed cough medicine)? The preliminary results look good. I understand that results have been released but I can't find It. Please reply if you have info. Thanks
Badmouth profile image
Badmouth
in Cure Parkinson's
2 months ago
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Started Ambroxol this week

I started Ambroxol at 17/day x 75mg (1275mg) tablets this week. I feel good so far. Hopeful. Fingers crossed. Wish I was in UK so I could participate in the study so this would be free, but it's also good to know I'm not in the placebo group.
I started Ambroxol at 17/day x 75mg (1275mg) tablets this week. I feel good so far. Hopeful. Fingers crossed. Wish I was in UK so I could participate in the study so this would be free, but it's also good to know I'm not in the placebo group.
easterners profile image
easterners
in Cure Parkinson's
2 months ago

Ambroxol is an antihistamine. High histamine associated with PD. Low histamine associated with RLS

Ambroxol is an antihistamine. I take Ambroxol. Antihistamines can worsen RLS. But not all and I don’t know why not all. RLS and PD are opposites in some ways like iron metabolism. My puzzle: why do I have RLS now and simultaneously less PD symptoms?
Ambroxol is an antihistamine. I take Ambroxol. Antihistamines can worsen RLS. But not all and I don’t know why not all. RLS and PD are opposites in some ways like iron metabolism. My puzzle: why do I have RLS now and simultaneously less PD symptoms?
Little_apple profile image
Little_apple
in Cure Parkinson's
3 months ago

My Stack - Need Suggestions

HCL 500 mg capsule Vitamin B1 HCL 100 mg capsule Vitamin B3 Nicotinic Acid 100 mg capsule Methyl B Complex Melatonin 10 mg Magnesium L-Threonate Vinpocetine 10 mg Probiotics 50 billion CFU 16 strain blend PS128 and PS128+K21 Ginkgo Biloba 120 mg + Bacopa 380 mg Turmeric 500 mg Lithium Orotate 5 mg Ambroxol
HCL 500 mg capsule Vitamin B1 HCL 100 mg capsule Vitamin B3 Nicotinic Acid 100 mg capsule Methyl B Complex Melatonin 10 mg Magnesium L-Threonate Vinpocetine 10 mg Probiotics 50 billion CFU 16 strain blend PS128 and PS128+K21 Ginkgo Biloba 120 mg + Bacopa 380 mg Turmeric 500 mg Lithium Orotate 5 mg Ambroxol
JayPwP profile image
JayPwP
in Cure Parkinson's
3 months ago

Edited: PD increases chance of RLS.(yes) Azilect worsens RLS.(wrong) Ambroxol, being an antihistamine I believe worsens RLS.(incorrect)

Ambroxol is an antihistamine. On the RLS forum I was told “not that kind of antihistamine,”. I have yet to research that further. Some antihistamines are said to worsen RLS.
Ambroxol is an antihistamine. On the RLS forum I was told “not that kind of antihistamine,”. I have yet to research that further. Some antihistamines are said to worsen RLS.
Little_apple profile image
Little_apple
in Cure Parkinson's
4 months ago

Anyone in the UK interested in a webinar entitled “Getting Involved in Trials and the PD Community”?

This was a survey created to understand everyone's experiences of clinical trials, from trial participants to those who design and those who commission trials in Parkinson's.AsPro-PD (Ambroxol to Slow Progression of Parkinson’s Disease – phase III of the Ambroxol trial): Professor Tony Schapira.
This was a survey created to understand everyone's experiences of clinical trials, from trial participants to those who design and those who commission trials in Parkinson's.AsPro-PD (Ambroxol to Slow Progression of Parkinson’s Disease – phase III of the Ambroxol trial): Professor Tony Schapira.
EJMo profile image
EJMo
in Cure Parkinson's
6 months ago

Ambroxol Phase 3 beginning in 2023

This may be old news but I thought I would post https://www.uclh.nhs.uk/news/cough-medicine-offers-hope-new-treatment-slow-progression-parkinsons-disease
This may be old news but I thought I would post https://www.uclh.nhs.uk/news/cough-medicine-offers-hope-new-treatment-slow-progression-parkinsons-disease
Canddy profile image
Canddy
in Cure Parkinson's
5 months ago

Ambroxol soon to enter Phase 3 trial

https://www.medicalnewstoday.com/articles/why-do-researchers-think-a-cough-medicine-could-help-treat-parkinsons?apid=32293354&rvid=e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855
https://www.medicalnewstoday.com/articles/why-do-researchers-think-a-cough-medicine-could-help-treat-parkinsons?apid=32293354&rvid=e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855
Xenos profile image
Xenos
in Cure Parkinson's
4 months ago

Experimental treatment for PD

Does anyone know anything about the clinical trials going on in the UK with Ambroxol as a treatment for PD (a repurposed cough medicine)? The preliminary results look good, but I can't find anything after 2021.
Does anyone know anything about the clinical trials going on in the UK with Ambroxol as a treatment for PD (a repurposed cough medicine)? The preliminary results look good, but I can't find anything after 2021.
Badmouth profile image
Badmouth
in Cure Parkinson's
9 months ago

Ambroxol

There are trials going on in the UK and elsewhere about the repurposing of the drug ambroxol in the treatment of Parkinsons. I am duplicating their dose of 1.2 g/d to see if it helps my PD. They have already proven that this high dose is well tolerated.
There are trials going on in the UK and elsewhere about the repurposing of the drug ambroxol in the treatment of Parkinsons. I am duplicating their dose of 1.2 g/d to see if it helps my PD. They have already proven that this high dose is well tolerated.
Badmouth profile image
Badmouth
in Cure Parkinson's
9 months ago

Hello. I’m new here.

Additionally I have been on a very high dose of the antihistamine Ambroxol. It is being trialed for PD which is why I have been taking it. But I learned that antihistamines can worsen RLS? I’m so sad to be facing this particularly at such a young age.
Additionally I have been on a very high dose of the antihistamine Ambroxol. It is being trialed for PD which is why I have been taking it. But I learned that antihistamines can worsen RLS? I’m so sad to be facing this particularly at such a young age.
Little_apple profile image
Little_apple
in Restless Legs Syndrome
4 months ago

Ambroxol trial started in 2022. 60 participants. Italy

https://clinicaltrials.gov/ct2/show/NCT05287503 GBA1 mutations reduce the enzymatic function of GCase,
https://clinicaltrials.gov/ct2/show/NCT05287503 GBA1 mutations reduce the enzymatic function of GCase,
Little_apple profile image
Little_apple
in Cure Parkinson's
6 months ago

Ambroxol

Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months.
Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months.
Badmouth profile image
Badmouth
in Cure Parkinson's
4 months ago

Phase II trial of ambroxol as a disease modifying therapy for Parkinson’s disease dementia

Phase II trial of ambroxol as a disease modifying therapy for Parkinson’s disease dementia https://youtu.be/hpsa1gA6qyk
Phase II trial of ambroxol as a disease modifying therapy for Parkinson’s disease dementia https://youtu.be/hpsa1gA6qyk
Hidden profile image
Hidden
in Cure Parkinson's
1 year ago

Exciting research taking place and information about the upcoming Ambroxol Trial.

Apologies if this has already been posted however this webinar i found very encouraging :) https://www.youtube.com/watch?v=7csdnja3QEE
Apologies if this has already been posted however this webinar i found very encouraging :) https://www.youtube.com/watch?v=7csdnja3QEE
JustJeff profile image
JustJeff
in Cure Parkinson's
1 year ago

Selegiline is Neuroprotective

I have not determined if this would apply to Ambroxol and Montelukast. Does anyone know? (Ambroxol and Montelukast are believed to protective as well. This can be elaborated upon in a different thread.)
I have not determined if this would apply to Ambroxol and Montelukast. Does anyone know? (Ambroxol and Montelukast are believed to protective as well. This can be elaborated upon in a different thread.)
Hidden profile image
Hidden
in Cure Parkinson's
1 year ago

citicoline or PEA?

. , mannitol or ambroxol or Berberine. Wondering if I should start on at least one of them for my symptoms. If yes, any suggestions which one should I go with? thanks so much for guiding me!
. , mannitol or ambroxol or Berberine. Wondering if I should start on at least one of them for my symptoms. If yes, any suggestions which one should I go with? thanks so much for guiding me!
Divii profile image
Divii
in Cure Parkinson's
6 months ago

A question to Ambroxol users

I just googled for "ambroxol" and got a page for "Ambroxol AL 30 mg Tabletten zur Schleimlösung, 100 pcs.
I just googled for "ambroxol" and got a page for "Ambroxol AL 30 mg Tabletten zur Schleimlösung, 100 pcs.
Lana666 profile image
Lana666
in Cure Parkinson's
1 year ago
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