Experiences with

Ambroxol

Ambroxol to Slow Progression in Parkinson Disease (ASPro-PD): https://clinicaltrials.gov/ct2/show/NCT05778617

a clinical trial of ambroxol called ‘Ambroxol to Slow Progression in Parkinson’, or the ‘ASPro – PD’ trial, will begin. This is a large phase 3 clinical trial to determine if ambroxol can slow or stop Parkinson’s.

Does anyone know anything about the clinical trials going on in the UK with Ambroxol as a treatment for PD (a repurposed cough medicine)? The preliminary results look good. I understand that results have been released but I can't find It. Please reply if you have info. Thanks

I started Ambroxol at 17/day x 75mg (1275mg) tablets this week. I feel good so far. Hopeful. Fingers crossed. Wish I was in UK so I could participate in the study so this would be free, but it's also good to know I'm not in the placebo group.

Ambroxol is an antihistamine. I take Ambroxol. Antihistamines can worsen RLS. But not all and I don’t know why not all. RLS and PD are opposites in some ways like iron metabolism. My puzzle: why do I have RLS now and simultaneously less PD symptoms?

HCL 500 mg capsule Vitamin B1 HCL 100 mg capsule Vitamin B3 Nicotinic Acid 100 mg capsule Methyl B Complex Melatonin 10 mg Magnesium L-Threonate Vinpocetine 10 mg Probiotics 50 billion CFU 16 strain blend PS128 and PS128+K21 Ginkgo Biloba 120 mg + Bacopa 380 mg Turmeric 500 mg Lithium Orotate 5 mg Ambroxol

Ambroxol is an antihistamine. On the RLS forum I was told “not that kind of antihistamine,”. I have yet to research that further. Some antihistamines are said to worsen RLS.

This was a survey created to understand everyone's experiences of clinical trials, from trial participants to those who design and those who commission trials in Parkinson's.AsPro-PD (Ambroxol to Slow Progression of Parkinson’s Disease – phase III of the Ambroxol trial): Professor Tony Schapira.

This may be old news but I thought I would post https://www.uclh.nhs.uk/news/cough-medicine-offers-hope-new-treatment-slow-progression-parkinsons-disease

https://www.medicalnewstoday.com/articles/why-do-researchers-think-a-cough-medicine-could-help-treat-parkinsons?apid=32293354&rvid=e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855

Does anyone know anything about the clinical trials going on in the UK with Ambroxol as a treatment for PD (a repurposed cough medicine)? The preliminary results look good, but I can't find anything after 2021.

There are trials going on in the UK and elsewhere about the repurposing of the drug ambroxol in the treatment of Parkinsons. I am duplicating their dose of 1.2 g/d to see if it helps my PD. They have already proven that this high dose is well tolerated.

Additionally I have been on a very high dose of the antihistamine Ambroxol. It is being trialed for PD which is why I have been taking it. But I learned that antihistamines can worsen RLS? I’m so sad to be facing this particularly at such a young age.

https://clinicaltrials.gov/ct2/show/NCT05287503 GBA1 mutations reduce the enzymatic function of GCase,

Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months.

Phase II trial of ambroxol as a disease modifying therapy for Parkinson’s disease dementia https://youtu.be/hpsa1gA6qyk

Apologies if this has already been posted however this webinar i found very encouraging :) https://www.youtube.com/watch?v=7csdnja3QEE

I have not determined if this would apply to Ambroxol and Montelukast. Does anyone know? (Ambroxol and Montelukast are believed to protective as well. This can be elaborated upon in a different thread.)

. , mannitol or ambroxol or Berberine. Wondering if I should start on at least one of them for my symptoms. If yes, any suggestions which one should I go with? thanks so much for guiding me!

I just googled for "ambroxol" and got a page for "Ambroxol AL 30 mg Tabletten zur Schleimlösung, 100 pcs.