Experiences with

Ambroxol

Ambroxol also appears to reduce Parkinson’s-related alpha-synuclein levels.

There are other threads addressing Ambroxol but from what I’ve seen, only one PWP has shared their personal experience.

There are trials continuing with Ambroxol, wondered if any of you have tried it and at what dose and if it had any effect? I know in the trial they are eventually having up to 1050 mg per day. Thanks!

Hi all This is a link to my vlog about the recent clinical trial of ambroxol for PD. https://youtu.be/zbqcdxcNWCc Cheers, Ian

There was a 6.8 reduction (indicating improvement) in the clinician-based rating scale measurement and these effects were seen in those participants with and without GBA mutations https://www.cureparkinsons.org.uk/news/ambroxol-phase-ll-results-published?

https://www.cureparkinsons.org.uk/news/ambroxol-phase-ll-results-published https://jamanetwork.com/journals/jamaneurology/fullarticle/2758317 Open study with no placebo but interesting results. There is a larger scale placebo study currently taking places in France.

Hi Friends, follow the link: https://www.parkinson.org/blog/science-news/Drug-Ambroxol.

breakthroughs for the next 2 decades: "New therapeutic targets following the discovery of genetic risk factors, such as autosomal dominant mutations in the LRRK2 gene; and the enzyme glucocerebrosidase (GCase), which is reduced in patients with mutations in the GBA gene - including treatment with Ambroxol

several promising developments, including: New therapeutic targets following the discovery of genetic risk factors, such as autosomal dominant mutations in the LRRK2 gene; and the enzyme glucocerebrosidase (GCase), which is reduced in patients with mutations in the GBA gene – including treatment with Ambroxol

Drugs covered in this review article: Ambroxol, Isradipine, Inosine, UDCA, Deferiprone, Exenatide, Nilotinib, Simvastatin. https://link.springer.com/epdf/10.1007/s40263-018-0548-y?

Is anybody taking Ambroxol and if so is there any symptomatic improvement? I understand Ambroxol is available as over-the-counter medication in Europe. There are clinical trials going on and some clinics in Israel use it in treating Parkinson's.

https://scienceofparkinsons.com/2017/04/16/an-ambroxol-update-active-in-the-brain/

AAV2-hAADC Ambroxol AZD3241 BIIB054 CDNF 18 Exenatide (Diabetes Drug) Fucoidan GM608 Inosine Isradipine LDN (Low Dose Naltrexone) LRRK2 Mannitol MSDC-0160 (Diabetes Treatment) NAC Neurturin Nilotinib Nicotine NPT200-11 NRF2 Opicaone OXB-102 PRX002 Ursodiol Uridine Vatiquinone