Update 6/29/22: Berberine may be neurotoxic. It is off of my stack: healthunlocked.com/cure-par...
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I have not been diagnosed with PD. I have REM Sleep Behavior Disorder, a sore left shoulder and sore left leg, random twitching, and depression.
1. Follow the Solar Cycle: I get up when the sun comes up. Got to bed no later than 11:30 PM. Wear blue blockers after 8 PM. (due to depression and crappy weather I have not been getting up with the sun lately. I will try harder).
2. Specific Carbohydrate Diet: Has been shown to normalize the microbiome.
3. Circadian Diet: Only eat when the sun is out.
4. Intermittent Fasting: Only eat during an 8 hour window. Usually sometime between 10 AM and 6 PM.
5. Broccoli Sprout and Daikon Radish sprout smoothie. Mix in a little oil and vinegar dressing: Drink it between 8:30 AM and 12:00 PM so I am boosting Nrf2 while my circadian rhythm is on the upstroke.
6. lactobacillus Casei Shirota (Yakult): Anti-bacterial, anti-fungus, anti-inflammatory, anti-viral, reduces cortisol levels.
7. Dr. Matthew Best Prebiotics and Probiotics for Women. It has (among other things):
- Lactobacillus acidophilus
- Lactobacillus reuteri
- Bifidobacterium bifidum
- Lactobacillus fermentum
8. Berberine: 400 mg twice a day. Neuroprotective.
9. Vinpocetine: 30 mg twice a day (with food or your body absorbs nearly none of it). Supposed to increase blood flow to the brain.
10. 2 teaspoons of Brewer's Yeast on my food once a day.
11. Niacin Rapid Release 150 mg in the morning and 150 mg at night. I ran out of time released and decided to switch to the rapid release twice a day.
12. CBD Oil: Right before bed.
13. Exercise: 20 minutes on the treadmill. Long walks when the weather is nice. (Due to depression and crappy weather I have been failing here).
14. L Methylfolate 15 mg (for depression).
15. Lithium Orotate 15 mg. This is for depression AND it may be neuroprotective. They are doing a trial on Lithium for PD in Buffalo.
16. Magnolia Bark Extract 200 mg (90% Honokiol and Magnolol) at night. This is supposed to help with REM Sleep Behavior Disorder and be neuroprotective.
17. S Boulardii (to kill pathogens). I don't take this every day, but I think I should.
18. Mixture of 1 teaspoon ground Nigella Sativa, and one teaspoon Ceylon Cinnamon (my teaspoons are heaping), and 600 mg of Organic Licorice Root Extract 20:1 Powder and 600 mg of UM Palmitoylethanolamide. I mix this with some peanut butter and raw honey and eat with a spoon twice a dayin the middle of the day. These are all antibacterial, anti-fungal, and anti-inflammatory. I'm trying to treat my microbiome from mouth to gut.
19. NAC 1200 mg with Taurine 1000 mg: 1 hour before bed.
20. 600 mg Palmitoylethanolamide in the morning and 600 mg at night. These are "Life Extension Comfort MAX – Honokiol & Pea for Nerve Support & Discomfort Relief – Gluten-Free, Non-GMO, Vegetarian - 30 AM Vegetarian Tablets - 30 PM Vegetarian Tablets". So 2 pills a day and the evening pill has 180 mg of Honokiol in it.
21: Methylene Blue 5 mg in the afternoon.
So I am at 21 items now. 4 of them lifestyle changes, so 17 supplements. You can see I am taking two different forms of Palmitoylethanolamide. The life extension is not Ultra Micronized but I like that it has AM and PM doses and has Honokiol in the PM dose. I also take the Magnolia Bark extract as that has Honokiol AND Magnolol and gets my daily dose of Honokiol and Magnolol up to almost 400 mg.
Except for depression I am doing pretty well. I hardly ever have RBD episodes. My skin on my face looks better (not seeing any seborrheic dermatitis on my face). My neck used to be sore all the time and it is mostly fine now. It's just the twitching and sore left shoulder and leg now. And the depression, but the depression is really a separate issue. I have made serious mistakes in my life.
Edit June 3rd 2022: Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...
"methylene blue oral and levodopa oral
methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."