So I took Vinpocetine yesterday, 2 doses of 30 mg, which put me at the high end (or over) the recommended dosing). Woke up feeling nauseous. Then I read Elliot's and Julie's warning and article verywellhealth.com/the-bene...
I'm gong to shelve this one for now.
Possible Side Effects
Side effects of vinpocetine may include indigestion, nausea, dizziness, anxiety, facial flushing, insomnia, headache, drowsiness, and dry mouth. Vinpocetine may also cause a temporary drop in blood pressure (hypotension).
Vinpocetine has raised concerns in recent years following reports that the drug may cause immune suppression. One such case resulted in agranulocytosis, a potentially dangerous drop in white blood cells that leaves you at high risk of serious infections.
Because of this, vinpocetine should never be used in organ recipients, people with advanced HIV infection, or those on immune suppressive drugs (including chemotherapy).
Vinpocetine may slow blood clotting and should be avoided in people with bleeding disorders or who take anticoagulants like Coumadin (warfarin) or anti-platelet drugs like Plavix (clopidogrel). Vinpocetine should not be taken two weeks before or after surgery to reduce the risk of excessive bleeding.
Due to the lack of long-term safety research, vinpocetine should not be used in children, pregnant women, or nursing mothers.
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Instead of short term what about “hit and run” as I’ve heard doctors refer to it where one uses it a couple days a month or once a week? This is done with Quercitin and metformin.
That is a big dose. I’m taking 10mg x 3 times daily, as suggested by Art, for memory problems, no PD. I’m getting indigestion. Art said it’s effect doesn’t last, so needs to be broken up (maybe not 2 x 30mg 🤔)
>>> ' Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many countries for treatment of cerebrovascular disorders such as stroke and dementia for more than 30 years. Currently, vinpocetine is also available in the market as a dietary supplement to enhance cognition and memory. Due to its excellent safety profile, increasing efforts have been put into exploring the novel therapeutic effects and mechanism of actions of vinpocetine in various cell types and disease models. Recent studies have revealed a number of novel functions of vinpocetine, including anti-inflammation, antagonizing injury-induced vascular remodeling and high-fat-diet-induced atherosclerosis, as well as attenuating pathological cardiac remodeling. These novel findings may facilitate the repositioning of vinpocetine for preventing or treating relevant disorders in humans. ' <<<
>>> ' No significant side effects and toxicity have been reported for vinpocetine at therapeutic doses and it is generally thought to be safe for long-term use. '<<<
>>> ' Vinpocetine has been clinically used in many Asian and European countries for the prevention and treatment of stroke, senile dementia, and memory disturbances. ' <<<
Did you note the credentials of the review author?
The bold quote is in direct conflict to your quote below which you didn't say where it came from:
"it is generally considered safe for short-term use". Short term use
The dose you took seems high compared to study dosing I have seen of 30 mg/day.
"Nonetheless, because no significant adverse effects of vinpocetine administration have been reported either in our study, in the literature, or in clinical practice, it is generally considered safe for short-term use"
You kwow what I did, I saw the price per milligram was better with the 30 mg capsules than the 10 mg capsules and painted myself into a stupidity corner.
I just google th two compounds eg vincopetine and levodopa say. It says if there is a known interaction. I would also consider the effect of taking two things that have a similar effect as they might be additive or even amplify the effect of each other. Try and understand what the mechanism is of the compound ie what it affects, and then seee if other things do the same job, particularly a pharmaceutical. Eg St. John’s wort has effects similar to ssri so you might overdose yourself if you start taking them together.
Maybe make a spreadsheet of each new thing, how it works, interactions you can find and what the purpose of taking it is.
I plan to do 10mg Vinpocetine post lunch for 3 days as introduction, then Vinpocetine 10mg post lunch and, Vinpocetine 20mg + Ginkgo 120mg + Bacopa 380mg post dinner.
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