The Biohacking team was created to enter XPrize Healthspan, but we have decided not to sign their competitors agreement and hence are likely to withdraw.
The team is based around a hypothesis that the diseases of aging (including Parkinsons) are caused by mitochondrial inefficiency (from damage to mitochondrial DNA) and its consequent effects on cytosolic acetyl-CoA levels.
We work on the basis of coached biohacking (which people don't pay for) and have been coaching a person diagnosed with Parkinsons with some success.
We are interested in finding further people who may be willing to try coached biohacking to resolve Parkinsons. We are not asking for any money, but people will have to pay for their own tests and their own interventions. They will also have to be self disciplined and focussed on the science.
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Mitochondria ensnared by defective alpha synuclein and thereby put out of action likely do play an important role in Parkinson's pathology. See image here for further detail: healthunlocked.com/cure-par....
Are your interventions based upon published research?
That sound like a no? Please give us some evidence you're not full of sh*t. Can you link to any research or heck even a third party article explaining what "coached biohacking is?
I don't want to seem hostile, but as other have pointed out this community is frequently targeted by scammers so we DO need a certain level of vigilance.
For example Menatrenone has been used in some trials, but there are issues about dosing. That depends substantially on how it affects individuals. Mk7 (Menatrenone, Menaquinone-7 also a form of vitamin K2) is used in Bacteria to generate energy. COQ10 forms a similar role in the human ETC.
The effect is an increase in mitochondrial efficiency with the knock on effect on gene expression. Now you could simply buy some and try it and comment on the forum. It is, however, complex and likely to disrupt sleep.
You will find some of this in the literature, but not all of it. AFAICS only my team has been experimenting with varying daily doses and high doses of Mk-7.
It varies. You can get mk-7 from Natto. We have identified that mk-7 reduces parkinson's symptoms. It is complex because it has a 75 hour half life. The top dosage we have tried so far is 50mg, but that has not been tried for Parkinsons. We are not sure of the balance between natto and mk-7, but the natto is eaten also with a dose of 100mcg.
Warning: Do not try large doses of mk-7 without first talking to a medical advisor.
Regarding your warning to consult a medical "advisor" about mk7. Most medical doctors are not educated about supplements, and even if they are expecting one to be knowledgeable about high doses of mk7 is definitely a bridge too far. So just who exactly are you expecting people to consult with about this other than yourself?
It may be worth consulting with you. I don't know. However, people should not just dive in to high doses of supplements without talking to someone with some experience. Medical Doctors may have an idea. The NOAEL on rats and mice for mk7 is quite high and we have little experience with high doses for people.
A further point to note is that there is a transcription pathway that starts in the mitochondria and ends up with the production of mRNA. This can be influenced at various points. MK-7 increases the Mitochondrial Membrane Potential and drives things in that way. Other interventions such as Yang Qi and Rapamycin operate to make the mitochondria more efficient (through AMPK and mitophagy). You can also intervene in the cytosol. This is, however, quite complicated and people cannot just pop a pill a day and expect a major result.
I am a devoted practitioner of Qigong. I work with Mingtong of the Wisdom Healing School of Qigong. We do not differentiate between yin and yang Qi. What specifically do you mean by Yang Qi?
It seems that Coached Biohacking may be yet another attempt to capitalize on a vulnerable target like PD through this forum. Your responses lack sufficient information, and you have not adequately addressed park_bear ‘s earlier question. It is crucial to refer to peer-reviewed studies that support your claims.
Furthermore, it is important to clarify which tests and interventions individuals will need to pay for themselves, as well as whether these practices are safe and effective.
I would like to give you the benefit of the doubt, but I believe that more transparency and clarity on these issues is necessary.
A problem on testing is that does vary from person to person.
As far as Parkinsons itself we have been looking at a reduction in parkinsons symptoms, that is slightly subjective, but can be quantified in some ways. I don't think there is a cost there.
From time to time I suggest using a CGM to monitor glucose handling. Higher levels of glucose cause more ROS which creates more mtDNA damage.
Also full panel blood tests can be useful. Wearing a tracker is also useful although I understand sometimes that can cause sleep anxiety that is a sufficient reason not to wear a tracker.
In terms of transparency I am not trying to conceal my name which is found on my blog where I write about these things
Interventions such as menaquinone-7, pantethine, rapamycin, melatonin and citrate are quite well known and there is published research on them, but the key is
a) An identified targeted mechanism.
b) A combinatory approach. At this stage I think the combination of interventions needs to vary from person to person. Pantethine, for example, cause anhedonia in a very small proportion of the population, but for those people it is ill advised.
I do participate in a number of online forums, but have been doing the biohacking coaching on a one to one basis. This enables people to talk openly about their concerns. I don't think it can just be handled through a forum.
At this stage I am not promising anything other than some of my time for free hence a disclaimer is essential.
Your reply indicates to me you have entirely missed the point. Raising uric acid levels makes Parkinson's worse, not better, in addition to creating elevated risk of stroke and heart attack.
The piece that I linked to, The Uric Acid Failure: Lessons Learned, explained that kidney stones are one of the adverse effects of raising uric acid. Do you mean to tell me you were not referring to this article?
I simply made a comment that one of the side effects (kidney stones) can be mitigated by citrate. However, I have never suggested to anyone that they should increase urate. In fact I warn people considering molybdenum supplementation that they should be sensitive to its effects on urate. I don't disagree with any of your comments about urate.
To be blunt, I just don't think "biohacking" and "Parkinsons disease" go together.
Biohackers are generally healthy individuals who like to self experiment, to optimise, etc. They are experimenting on themselves and taking risks. How calculated or well educated those risks are varies between different biohackers.
Parkinson's patients have a serious, degenerative neurological illness. I think the window for experimentation and risk taking is far, far narrower in these patients.
Not to say they won't experiment a little bit. PD is still seen as incurable and progressive by mainstream medicine, yet there exist cases where patients have dramatically improved their symptoms at times. So obviously PD patients are going to try their best to find such alternative approaches that may help them. I'd say many people on this forum fall into that category.
But i just think it needs to be done with far more caution and oversight than the general biohacker. Probably as part of a team with the neurologist, family doctor, allied health professionals, all working together. A single biohacking coach isn't going to cut it, imo.
That, of course, is an individual decision. I am not looking for large numbers of people, but there are individuals who have PD who are also quite scientifically focused and read the literature themselves. I am not looking for "patients". The offer is there.
It’s impressive, John Hemming, that you and your biohacking-team can support individual cases of Parkinson's disease. To be honest, I believe Laurie Mischley has more expertise in this area. Perhaps it’s unfair of me to think that your focus might be more on selling 'Royal jelly for humans' to us? There’s nothing wrong with that, if it could lead to proven significant improvements in managing Parkinson's symptoms. However, I kindly ask for transparency regarding this.
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