Who has tried Methylene Blue?

[Bolt_Upright]

Searching the web, people have been talking about Methylene Blue for PD for at least 10 years. Has anybody tried it? Any details to share?

Edit June 3rd 2022: Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...

"methylene blue oral and levodopa oral

methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."

[Despe]

Hi Bolt! Husband's second day on MB. Nothing significant to report as of yet. Will update as needed.

[Bolt_Upright in reply to Despe]

Thanks Despe, how much is he trying?

[Despe in reply to Bolt_Upright]

With the lowest dose (0.5X77kg), approximately 38mg.

[Bolt_Upright in reply to Despe]

In this study with LMTM (an MB derivative) they used 4 mg twice a day for AD as the sham treatment and it was just as effective as the large doses. ncbi.nlm.nih.gov/pmc/articl...

I don't think they know the lowest effective dose. I plan on starting at about 8 mg.

[Despe in reply to Bolt_Upright]

You suppose I should lower his dose?

[Despe in reply to Despe]

LMTM is a derivative, so I am not sure if its properties are same as MB's.

[Bolt_Upright in reply to Despe]

I hesitate to offer advice. I'm just starting low (partly because of my Prozac issue). Your dosing is mirroring what I see on the web.

[Bolt_Upright]

Okay, I just tried my Methylene Blue. I mixed one gram of the powder with 100 ml of water, and then drew out .5 ml of the mixture (which should be 5 mg of MB) and put that in about 4 ounce of water and drank it down. I plan on starting out low. Probably stay at 5 mg a day for at least a week.

[chartist in reply to Bolt_Upright]

When I tested MB years ago, I noticed that as I increased the dose, my mental alertness noticeably increased in a manner that I found similar to amphetamine without the jitteriness that amphetamine can cause in some people. I also noticed that the higher I dosed, the bluer my urine got. It was a short experiment because the quality of the MB I was using was questionable. I don't have any plans to test it again and it was so long ago, I can't remember the doses I used.

Art

[Bolt_Upright in reply to chartist]

I made a little documentary on the effects so far...youtu.be/zJbuxoZVPIg(Not working as expected?)

[SilentEchoes in reply to Bolt_Upright]

LOL!

[Hidden in reply to SilentEchoes]

SE, I think that Trehalose is being trialed for ALS. If I understand anyways it’s being in the blood. I just posted about it. It’s available as a sugar substitute now

[Angelhawk in reply to Bolt_Upright]

Great job on this documentary Bolt!!!!!!!!

[MBAnderson in reply to Bolt_Upright]

ha

[Bolt_Upright in reply to chartist]

I got 5 grams for $70 amazon.com/gp/product/B08JL...

At 10 milligrams a day this would last me 500 days.

[MBAnderson in reply to chartist]

Did you consider blue urine a questionable indicator?

[chartist in reply to MBAnderson]

It is commonly seen with the use of MB. I think I read where vitamin C can counteract that effect, but I didn't test that idea while I was testing MB.

Art

[MBAnderson in reply to chartist]

blue urine does not appeal to me.

[chartist in reply to MBAnderson]

If I remember correctly, I had to be careful handling MB because it could stain, so I can see where it could have the potential to turn urine blue. It wasn't deep blue, more like a tint. On the plus side, given the medicinal qualities of MB, I would fully expect it to treat UTI's effectively, though I have never tried it for that purpose.

Art

[MBAnderson in reply to chartist]

Oh, a blue tint. Perfectly fine.

[chartist in reply to MBAnderson]

On a related note, one reason I was testing MB is because it had quite a few similar qualities as melatonin such as inhibition of cognitive decline, potent antioxidative stress effects, activation of NRF2, decreased apoptosis of neurons and repair of the blood brain barrier, which has been shown to be perturbed in PD models.

One important area where I found that they differed was in their abilities to actually cross the blood brain barrier. Melatonin readily crosses the blood brain barrier while methylene blue was shown to be limited in this respect in PD models.

Art

[Gigi216 in reply to Bolt_Upright]

Good luck! It didn’t agree with me but I’ve read many people enjoy the benefits they get very much

[Bolt_Upright in reply to Gigi216]

How much did you try? What effects please?

[Chris1960-2]

You can see the YouTube account from Guy Tenenbaum « cancer therapy » m.youtube.com/playlist?list...

[Manypony]

I’m about to receive supposedly high quality MB I will certainly post here

[Zardoz]

Methylene blue has been around for over a century. If it had a significant benefit for PWP, that certainly would have been found out already.

It's pro-oxidant at high doses, and potentially dangerous for people taking anti-depressants. Industrial grade MB could be contaminated with heavy metals.

youtube.com/watch?v=SMiYWOO...(Not working as expected?)

Go to the 15:36 mark to see warnings.

[Bolt_Upright in reply to Zardoz]

Good points. DO NOT GO TO THE PET STORE FOR YOUR METHYLENE BLUE.

[dvoranel]

I haven’t watched the video yet but thought you might be interested

articles.mercola.com/sites/...

[Bolt_Upright in reply to dvoranel]

Thanks!

[Bolt_Upright]

I am on day 5 of 5 mg of Methylene Blue. My urine is greenish sometimes.

[chartist in reply to Bolt_Upright]

I got to a shade of medium blue while testing methylene blue, Bolt.

Art

[Bolt_Upright]

I am on day 8 of 5 mg. Also on day 3 of lowering my Prozac from 40 mg to 36 mg.

[Bolt_Upright]

I am on day 23. I have been on 10 mg for about 2 weeks (up from 5). Can't say I feel different. My dandruff is gone.

[chartist in reply to Bolt_Upright]

Methylene Blue has antifungal qualities, which is one cause of dandruff.

Art

[Bolt_Upright]

Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...

"methylene blue oral and levodopa oral

methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."