Searching the web, people have been talking about Methylene Blue for PD for at least 10 years. Has anybody tried it? Any details to share?
Edit June 3rd 2022: Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...
"methylene blue oral and levodopa oral
methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."
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In this study with LMTM (an MB derivative) they used 4 mg twice a day for AD as the sham treatment and it was just as effective as the large doses. ncbi.nlm.nih.gov/pmc/articl...
I don't think they know the lowest effective dose. I plan on starting at about 8 mg.
Okay, I just tried my Methylene Blue. I mixed one gram of the powder with 100 ml of water, and then drew out .5 ml of the mixture (which should be 5 mg of MB) and put that in about 4 ounce of water and drank it down. I plan on starting out low. Probably stay at 5 mg a day for at least a week.
When I tested MB years ago, I noticed that as I increased the dose, my mental alertness noticeably increased in a manner that I found similar to amphetamine without the jitteriness that amphetamine can cause in some people. I also noticed that the higher I dosed, the bluer my urine got. It was a short experiment because the quality of the MB I was using was questionable. I don't have any plans to test it again and it was so long ago, I can't remember the doses I used.
SE, I think that Trehalose is being trialed for ALS. If I understand anyways it’s being in the blood. I just posted about it. It’s available as a sugar substitute now
If I remember correctly, I had to be careful handling MB because it could stain, so I can see where it could have the potential to turn urine blue. It wasn't deep blue, more like a tint. On the plus side, given the medicinal qualities of MB, I would fully expect it to treat UTI's effectively, though I have never tried it for that purpose.
On a related note, one reason I was testing MB is because it had quite a few similar qualities as melatonin such as inhibition of cognitive decline, potent antioxidative stress effects, activation of NRF2, decreased apoptosis of neurons and repair of the blood brain barrier, which has been shown to be perturbed in PD models.
One important area where I found that they differed was in their abilities to actually cross the blood brain barrier. Melatonin readily crosses the blood brain barrier while methylene blue was shown to be limited in this respect in PD models.
Methylene blue has been around for over a century. If it had a significant benefit for PWP, that certainly would have been found out already.
It's pro-oxidant at high doses, and potentially dangerous for people taking anti-depressants. Industrial grade MB could be contaminated with heavy metals.
methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."
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