methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."
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Bolt_Upright
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L-dopa isn't an SSRI - it has an antagonistic effect on SSRI antidepressants. The 10mg dose you're taking is very low - 2mg/kg is the dose widely used in clinical trials. Reduce your dosage if you experience symptoms.
“My guess is that at > 0.5 – 1 mg per kg intra-venously it [methylene blue] will be active as an MAOI. When injected into tissues the systemic availability may be less, and the dose probably lower, so these situations are less likely to give rise to ST [serotonin toxicity] interactions. We know that in Sweet’s & Kartha’s series of 325 patients only those on SSRIs pre-operatively got symptoms, and not a single patient of the 280 who were not on SRIs got symptoms."
Methylene Blue (MB) oral is less bioavailable than MB by IV. A 200lb male is about 90kg. At .5 - 1 mg/kg the intravenous dose is 45-90 mg for MB to reach the threshold of becoming a MAOI that could interact with SSRI and SRI and risk serotonin toxicity.
Weird that the symptoms of serotonin syndrome matches the symptoms of Motor Neuron Disease/ALS 🤔. Key symptoms of serotonin toxicity are: Progressively - Tremor, then hyperreflexia (especially lower limbs), clonus (inducible, spontaneous, ocular), rigidity, hyperthermia. Autonomic overactivity (diaphoresis, BP, mydriasis, gut) and mental state change (excitement, confusion in late stage).
If you are taking a SSRI or one of the antidepressants named in Dr. Gillman's article - you need to be cautious. You should also be on a low tryptophan diet.
An oral dose of MB 10mg/day is unlikely to cause problems unless you are allergic. The antidote is anesthesia and paralysis - um, that's ALS.
The research paper I referenced says that MB might lower the effect of L-dopa, so keep this in mind when determining dosage. Maybe start at 5mg day/orally.
I feel safe self-medicating for treatment of methemoglobinemia in combination with high dose methylcobalamine (B12), NAD+ and hyperbaric oxygen.
Since PD begins years before symptoms appear, I'm starting my adult children on 10mg day oral MB for the rest of their life. No. More. Victims.
Yikes! "A Diet Lacking in Tryptophan Alters Gut Microbiota, Increases Inflammation. With age, a diet lacking in the essential amino acid tryptophan — which has a key role in our mood, energy level, and immune response — makes the gut microbiome less protective and increases inflammation body-wide, investigators report.Aug 14, 2021"
"Low" not no tryptophan. MB would need to be taken at a much higher dose to become an "effective" MAOI.
I'm taking 50 mg/day orally while undergoing HBOT, then I'll drop down to a maintenance dose of 10 mg/day orally - forever.
High dose L-tryptophan (1500 mg) was shown to ameliorate ALS. So does high dose melatonin. Don't think I have much to worry about at 10 mg/day MB. I will never ever take an SSRI drug.
Thanks, Glad I now Know: I haven't tried yet. I ordered some that was manufactured by a drug company, when I received, I read bottle and in was labeled "for external use only".
For anybody reading this: I plan to order a kit for making my own caps of TTDF the lowest dose I have found is 50mg, I do not like taking every other day and in the final wash I do not know what dose is going to be the best dose for me. I add Please, Don't take my n1, non-place human Guinea pig experience as approved treatment: talk with your doctor and do your research.
Bolt_Upright have you edited or commented this on your other posts about Methylene Blue.
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Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson’s disease
5-HTP in patients not taking Sinemet can worsen symptoms of PD
Has anyone actually seen results from Methylene Blue?.... 
