Probiotic supplementation may confer advantageous therapeutic potential for people with PD (lowers inflammation)

[Bolt_Upright]

Found this in an old post of Art's and thought it deserved its own topic healthunlocked.com/cure-par...

The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin and Lipid in Patients with Parkinson’s Disease: A Randomized, Double-blind, Placebo-Controlled Trial ams.ac.ir/AIM/NEWPUB/18/21/...

Subjects took 8×109 CFU/day probiotic, containing Lactobacillus acidophilus, Bifidobacterium bifidum, L. reuteri, and Lactobacillus fermentum (each 2 × 109) (n = 25) produced by Lactocare Zisttakhmir Company (Tehran, Iran).

This study evidenced that probiotic supplementation to patients with PD for 12 weeks significantly downregulated gene expression levels of IL-1, IL-8 and

TNF-α in PBMC compared with the placebo. Earlier, we have showed that probiotic supplementation for 12 weeks to patients with MS significantly decreased gene expression levels of IL-8 and TNF-α; however, it did not affect gene expression of IL-1.10 Furthermore, supplementation with Lactobacillus paracasei and L. reuteri in an animal model significantly decreased the expression of hepatic IL-1β, IL-6 and TNF-α through suppressing the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-kB) signaling pathways.19 Gene

expression of TNF-α, IL-1β and IL-6 was also up-regulated in intestinal mucositis tissues following the treatment with probiotics.20

Overall, probiotics supplementation for 12 weeks in PD patients significantly improved gene expression of IL-1, IL-8, TNF-α, TGF-β and PPAR-γ, but did

not affect gene expression of VEGF and LDLR, and biomarkers of inflammation and oxidative stress. This suggests probiotic supplementation may confer advantageous therapeutic potential for people with PD.

Everything except the Bifidobacterium bifidum is in this: Swanson Ultra- FemFlora Probiotic for Women ($8) swansonvitamins.com/swanson...

The Bifidobacterium bifidum is more expensive ($45): Bifidobacterium Bifidum Probiotic Powder 100 Billion cfu's 30 Gram | Digestive & Immune Support | High Potency | B. Bifidum amazon.com/Bifidobacterium-...