I have been taking Fatty15 for seven months. My B1 sweet-spot has dropped from 1000mg B1 hcl oral to ODing on 250mg. I am currently on a B1 break. My major problem has been Anxiety!!!!
Why has B1 sweet-spot declined? Maybe, B1 therapy is life-support for dysfunctional mitochondria; the Fatty15 has repaired and there are less dysfunctional mitochondria which require less life-support. And, the B1 caused too much energy.
I know of one other PwP that has taken a Fatty15 for a year. She has been on B1 Therapy for 5 months.
My advice, to anyone on B1 Therapy, if you start feeling anxiety, take a B1 break and when you start back reduce your B1 dose.
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Does anyone know if this is reliable source, is this true? Link says, "Pecorino cheese has the highest levels of C15:0." x.com/gregmushen/status/181...
Also, as it stands there there are supposedly different types of PD and many possible causes. I have not had blood tests to deteremine my C:15 levels. Could be my PD was partially caused by low levels of C:15.
Here is another video that says c15 is not essential as humans make it from short chain fatty acids and eating fibre.
Ferroptosis ie cell death from iron is caused by eating heme iron from meat.
So if you eat lots of fibre ie plant material and less meat c15 will increase, heme iron will decrease.
Our ancestors pooped out 100g or more of fibre per day (from fossil dung records) so we’d need to eat a huge amount of fibre per day to replicate that.
He doesn’t argue that c15 isnt beneficial, just that you’d be better eating masses of plants and no meat to get it. Which seems to correlate more with other research that meat and dairy are bad for you for all cause mortality.
"Here is another video that says c15 is not essential as humans make it from short chain fatty acids and eating fibre."
or
"He doesn’t argue that c15 isnt beneficial, just that you’d be better eating masses of plants and no meat to get it. Which seems to correlate more with other research that meat and dairy are bad for you for all cause mortality."
from watching this video.
Do you have another source to backup these statements?
I do get that you are better off taking C:15 than eating dairy because you don't get all the unhealthy fats.
"Gut bacteria can also produce some C15:0 from fiber, emphasizing the importance of a fiber-rich diet and a healthy gut microbiome." from connect.gdx.net/blog/2024/0...
The gut bacteria Parabacteroides distasonis can produce pentadecanoic acid (C15:0) from dietary inulin. nature.com/articles/s41564-....
I googled "what probiotic has "parabacteroides distasonis" in it?" AI's response, "No probiotics are known to contain Parabacteroides distasonis, but it is a gut microbiota member that has many beneficial properties."
Sorry, I was just trying to summarise the video. The original video the woman who discovered it said it was essential because the body can’t make it. But he is saying it’s not essential because it is made in your gut by bacteria that feed on fibre. He thinks she has a vested interest I think, because she is trying to sell it.
He says by eating a lot of fibre you can make it yourself.
The other alternative is eat lots of foods that have it in it like ghee, fatty meat and dairy. But Laurie mischley says those foods make PD progress faster. Also the book How not to Age goes says that meat and dairy speed up aging and disease. Dr Michel Gregor quotes many studies to back that up. So I was a bit confused as the c15 story and the other studies seem to contradict each other.
But if you watch the video he says our ancestors ate fibre all day, enough to poop out 100g or more every day! More plant material especially leafy greens seems to be commonly accepted to be the healthy thing to try and achieve, and he thinks it isn’t the reducing of the eating of fatty animal products that has decreased our c15, it’s the lack of fibre.
Dolphins however are made to eat fish so because it’s not in all fish equally the ones who eat the wrong fish aren’t getting enough.
No one is arguing it is not necessary for dolphins and humans. Or that taking the supplement will boost levels in your body. But you don’t need to buy an expensive supplement to do that. You can at lots of fibre, or fatty animal products which aren’t good for you for other reasons.
Here are the top inulin-rich foods per 100 grams (about 3.5 ounces), according to the International Probiotics Association.
Chicory Root: 41.6 grams. ...
Jerusalem Artichokes: 18 grams. ...
Dandelion Greens: 13.5 grams. ...
Garlic: 12.5 grams. ...
Leeks: 6.5 grams. ...
Asparagus: 2.5 grams. ...
Wheat Bran: 2.5 grams. ...
Bananas: 0.5 grams.
wheat germ also has spermadine in high quantities which is also very important. So maybe we should eat wheat berries, except they aren’t gluten free😞
but chat gpt says
The best plant-based food for boosting C15:0 (pentadecanoic acid) is a bit tricky to identify because C15:0 is most commonly found in ruminant animal products like dairy and meat from cows and sheep. However, certain plant-based foods do contain trace amounts of C15:0, though the levels are much lower than in animal-based sources.
Plant-Based Foods with Trace C15:0:
While plant-based foods are generally not rich in C15:0, some research indicates that a few plants contain small, trace amounts of this fatty acid, likely due to microbial synthesis in the soil or interactions with bacteria in the plant’s environment.
1. Cabbage:
Some studies have indicated that cabbage contains trace amounts of C15:0. This is likely due to microbial activity, as bacteria in the soil can produce odd-chain fatty acids that are absorbed by the plant.
2. Cucumber:
Like cabbage, cucumbers may contain tiny amounts of C15:0 due to microbial interactions in their environment.
3. Other Vegetables:
Broccoli and spinach may contain very small amounts of odd-chain fatty acids, including C15:0, though the levels are negligible compared to animal sources.
Fermented Plant-Based Foods:
Fermentation processes, involving bacteria, may increase the likelihood of odd-chain fatty acid production, including C15:0, though typically the amounts remain very low in plant-based fermented products.
Examples:
Fermented vegetables like sauerkraut (fermented cabbage) may contain small amounts of odd-chain fatty acids due to bacterial fermentation, but these amounts are still very low.
Can Plant-Based Diets Increase C15:0?
While plant-based foods generally do not provide significant sources of C15:0, some gut bacteria can produce C15:0 through fermentation of dietary fibers, but this contribution is likely modest.
If you are strictly following a plant-based diet, your intake of C15:0 will be limited. However, you can focus on promoting gut health through the consumption of high-fiber foods like legumes, whole grains, fruits, and vegetables, which support a diverse microbiome. This may indirectly support the production of beneficial short- and odd-chain fatty acids, though the direct contribution to C15:0 levels will be small.
Conclusion:
For a strictly plant-based diet, your best options for trace amounts of C15:0 are likely vegetables like cabbage and cucumber, though the levels are minimal. To optimize your overall health and indirectly support gut bacteria that might produce small amounts of C15:0, focus on a diverse diet rich in fiber, fermented foods, and whole grains. However, if C15:0 intake is a priority, plant-based diets are inherently limited in providing this specific fatty acid.
I just watched for the 3rd time. The video that I watched doesn't dispute that C12 is essential. The closest it comes is a statement similar to (Dr. Watsom claims essential).
I have a tendency to worry about what is probably nothing. It’s one thing to say eat more fiber, but if the right microbes aren’t in your gut to produce C:15 from fiber it would do no good to try to feed them. One of those source says parabacteroides distasonis found in the human gut (whose gut) will produce C:15 from fiber. How do I insure parabacteroides distasonis is in “my gut” – supplement it. I can only find one source that indicates they have parabacteroides distasonis and it is harvested from the human gut, but it looks like they sell only to the research/science community. dsmz.de/search?tx_kesearch_...
I just sent them an email asking, "Is there an availiable Probiotic that contains parabacteroides distasonis?"
I saw another paper listing a whole lot of other bacteria that also make it in various amounts. I think the theory is build it (the fibre filled gut) and they will come. I think a lot will arrive on the vegetables so long as they are grown in a field not hydroponically.
I asked chatgpt again about it and it says that you can’t make enough c15 from plants even if you eat lots of fibre. But it won’t quantify it.
Also “C15:0 (pentadecanoic acid), like other fatty acids, is both used by the body and accumulated in various tissues, depending on several factors, including diet and metabolic needs.
How C15:0 is Utilized:
Cell Membrane Health: C15:0 plays a role in maintaining the integrity of cell membranes. Once consumed, some C15:0 is used to help strengthen and stabilize cell walls, which supports cellular functions like protection against oxidative stress and inflammation.
Energy Metabolism: Like other fatty acids, C15:0 can be oxidized for energy in cells. However, C15:0 is not a major energy source compared to short- and medium-chain fatty acids (like butyrate or capric acid), so much of it may be stored or used for other biological processes.
Accumulation:
Stored in Tissues: When consumed, C15:0 can be stored in adipose tissue (fat) or deposited in cell membranes throughout the body. Research has shown that individuals with higher intakes of C15:0 (typically from diets rich in grass-fed dairy or meat) tend to have higher levels of this fatty acid in their plasma and tissues. This suggests that C15:0 can accumulate to some extent over time.
Does C15:0 Get Used Up Daily?
Yes, it gets used, but not completely. While C15:0 is metabolized and utilized for various functions (e.g., energy, cellular maintenance), it is not fully depleted on a daily basis. A portion of it remains stored in tissues and incorporated into cell membranes.
Over time, your body will use some C15:0 to support biological processes, but it is not rapidly depleted like water-soluble vitamins (e.g., vitamin C). Instead, it can be slowly released from tissues as needed.
Balance of Intake and Usage:
If you consume C15:0 regularly (e.g., through dairy or grass-fed meat), the fatty acid is likely to accumulate gradually in your tissues. This storage helps maintain its anti-inflammatory and cardiovascular protective benefits over time. However, without consistent intake, the stored levels may decline as the body uses it for maintenance, especially for cellular repair and inflammation reduction.
Conclusion:
C15:0 is partially used daily by the body, but much of it is stored in tissues or incorporated into cell membranes. Regular dietary intake helps maintain a beneficial level of C15:0 in the body, contributing to long-term health benefits. However, without sufficient dietary sources, the stored C15:0 will gradually be depleted over time as it is utilized for various cellular functions.”
So it seems that taking a supplement for a while to raise levels then eating mainly plants with a little ghee to top it up might be a good idea
I found a study of pentadecanoic acid (C15) for treatment of fatty liver. They didn’t supplement with C15 instead they feed the rats inulin enriched with Parabacteroides distasonis [which gives creditability to the idea of growing your own C15 and my thought that you should supplement with Parabacteroides distasonis]. nature.com/articles/s41564-...
* I am not a strong reader of jargon and I get lost.
** Google AI does state Parabacteroides distasonis is found in rat guts.
Well found. Maybe they just used that bacteria as it is naturally in the rat/mouse gut? I read there are many bacteria that can do it, they just need the inulin.
My husband had a great year, then got worse again. We have been trying this. Stopped b1 for 2 weeks. Over that time he slowly got even worse, so constipated and miserable. He is back on a slightly reduced dose (he was on 500mg/ 1g alternating ie 750 average per day for 3 years. We have dropped second dose most days so he is on 500mg per day with 2 extra in the week. His constipation has gone away again.
Today is day 9 of a B1 break. I will start back at a reduced dose. I am praying I can get back to "My PD is well controlled with B1". My biggest problem has been anxiety.
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