Keytruda Immunotherapy Update

[Chugach]

After running through pretty much most of the available SOC, I got a Hail Mary with a genetic test indicating I was MSI-H (micro satellite instability high) and thus approved for Pembrolizumab. After 4 cycles (12 weeks) of Pembro (Keytruda) my PSA went from 86 to undetectable: < 0.01. Just started cycle 5 yesterday. I was pretty much undetectable after cycle 3 < 0.07 (different lab). So far very minimal side effects (knuckles in my hands were aching so taking some ibuprofen to help with that) and all my labs look great. I did some high dose radiation to some bone mets during cycles 1 and 2 as I read that could help the T-cells bring the hammer down on the PC.

[tango65]

fantastic!! Best of luck!!

[Hidden]

Its great to hear good news!

[noirhole]

Awesome, I see genetic testing in my future.

[Chugach in reply to noirhole]

Check out Foundation Medicine/ Foundation One

[jfoesq]

Great news. May your excellent response continue for many years

[JLS1]

Wonderful!! SO happy for you! Congratulations!!

[Hidden]

Hello Chugach,

It’s Linda again. Hope this finds you doing well. If you don’t mind me asking.......were there any noticeable benefits after only one round of Keytruda (like PSA drop) ? My dad has just had his second infusion but PSA went up after the first round. I’m wondering if the effects are cumulative and will be seen after infusion 3 or 4.

Thanks in advance

[Chugach in reply to Hidden]

I never mind questions. I actually didn’t get a PSA reading before the second infusion- so I don’t know. but a continued rise prior to going down has happened to me on chemotherapy, 3rd infusion before dropping. I wish you the best

[Hidden]

Thank you, Chugach 😊

[Hidden]

Just curious did your insurance approve the Keytruda?

[Chugach in reply to Hidden]

Yes - it is considered standard of care for any cancer type with the correct genetic markers. There is a co-pay that is insane, but Merck has a co-pay assistance program that can cover out of pocket expenses.

[Hidden in reply to Chugach]

Thank you for that info my oncologist said insurance would not pay. Good luck in your journey. this gives me hope.

[ellie2211]

Where did you do the high dose radiation? Do you take supplements for immune strengthening?

[Chugach in reply to ellie2211]

I’ve done th Radiation at several locations associated with UC Health, including Anschutz Cancer Center and Fort Collins location. I have narrowed my supplements only to Tumeric and calcium/vitamin D

[ellie2211 in reply to Chugach]

Thank you for sharing. I hope you are doing well 💙

[witantric]

Great news. God bless