Experiences with

Pembrolizumab

I have been taking Ibrutinib for almost 5 weeks Pembrolizumab for 2 via IV. My doctor said if I end up in hospital it’s most not working. Do anyone have a suggested alternative? I have the ritchers syndrome mutation Thanks

My sister has stage 4 NSCLC and has stopped pembrolizumab due to side effects and disease progression, and is now on home oxygen. Starting carboplatin and pemetrexate next week. Any advice for handling the chemotherapy, side effects etc? She is in the UK. Thank you for any help you can give.

Drug/Therapy (Mechanism / Status) Sipuleucel-T (Autologous dendritic cell vaccine; approved) Pembrolizumab (PD-1 checkpoint inhibitor; approved for MSI-high) Ipilimumab (CTLA-4 checkpoint inhibitor; experimental in PC) Nivolumab + Ipilimumab (PD-1 + CTLA-4 combo; experimental) Thalidomide (Immunomodulator

The study, published in Cell Reports Medicine, focuses on a new treatment combining pembrolizumab with standard chemotherapy to treat small cell bladder cancer and small cell/neuroendocrine prostate cancer. Small cell carcinomas are aggressive and have a low survival rate.

The study, which involved dose-escalation and combination arms with pembrolizumab or low-dose IL-2, showed PSA reductions in some patients and confirmed the agent’s tolerability. However, the results did not justify further development.

How did being on affect your quality of life? If you have had adjuvant treatment after surgery, what was your experience? Would you have preferred to have treatment before surgery?

Immunotherapy & Clinical Trials • Pembrolizumab (Keytruda) – If genetic testing shows MSI-high or mismatch repair deficiency, immunotherapy could be an option.

Evidence: C – Pembrolizumab is approved for MSI-high solid tumors including a small fraction of CRPC, with ~20% response rates in that group. In AR-V7-positive, ARPI-resistant mCRPC, pembrolizumab yielded PSA or radiographic responses in ~18% in a Phase II trial.

Pembrolizumab (Keytruda): Pembrolizumab is a checkpoint inhibitor that targets PD-1 (programmed cell death protein 1).

. ----- Does anybody have any experience with or opinions on this trial: PLANE/PC - Phase 2 - Pembrolizumab + Lenvatinib https://clinicaltrials.gov/study/NCT04848337

The Pembrolizumab isn't too bad, but makes me feel a bit wiped out for a few days, no energy etc. The result is that I'm afraid to go far from home, or my hospital, in case something happens to make me feel unwell.

So I am still here, thanks to the Marsden, 4 cycles - now just on immunotherapy - have just read about durvalumab which I have never heard of, I', on the usual pembrolizumab - has anyone had experience or can tell me the difference between the two please?

. - Pembrolizumab. I'm due my 2nd treatment tomorrow. For someone who avoids taking anything stronger than paracetamol, it's all a bit scary. I haven't met anyone with lung cancer yet, and other people I know with cancer are on radio / chemo treatments. How have others found immunotherapy.

At the oncology appointment yesterday my husband was given what I believe is an amazing opportunity, he has the option of starting standard care ( immunotherapy pembrolizumab ) or participating in clinical trials where they will be also adding a second drug for a two pronged approach.

His treatment plan was to have Cisplatin and Pemetrexed (chemotherapy) and Pembrolizumab (Immunotherapy). He tolerated a number of cycles but then got a couple of infections at once and was very poorly.

A PSMA-targeting radioligand, Lutetium (177Lu) DGUL, with the anti-PD-1 therapy Keytruda (pembrolizumab) is being investigated in patients with advanced prostate cancer.

https://www.moffitt.org/clinical-trials-and-studies/clinical-trial-21340/

Having said that they also trialed solid tumour treatments eg Pembrolizumab in patients with MBC with HTMB, https://pubmed.ncbi.nim.nih.gov/33844595/ Genomics test called guardant360 in the US? ( blood or tissue) Not universal benefit but for advanced, Metatastic cancers.

I will be having paclitaxel, carboplatin, every 3 weeks for 4 rounds & pembrolizumab at the same time, then every 6 weeks for 2 years. Just wondered if anyone has had similar and how they got on? In August the hospital changed my inhalers to Anoro + Easyhaler.

I will be having paclitaxel, carboplatin, every 3 weeks for 4 rounds & pembrolizumab at the same time, then every 6 weeks for 2 years. Just wondered if anyone has had similar and how they got on? In August the hospital changed my inhalers to Anoro + Easyhaler.