Ice-Cap immunotherapy trial update

[easeytiger]

In October I started a phase 1 trial of ipatasertib in combination with atezolizumab. This immunotherapy trial is designed for patients with

advanced solid tumours with PI3K pathway hyperactivation. Today I got the scan results after three cycles which show no tumour progression and no significant SE's. This is still very early stages but I will now push on with the trial and see how I react to the treatment. I have been told PSA is only one key marker ( it has risen since trial started) with scans and how I feel being equally important. I am now one year into my Pc journey.

[joancarles]

It seems very interesting what you are doing. I hope it works very well for you. And I also appreciate the information you are publishing. It can be a very valid path.

How are you feeling?

[easeytiger in reply to joancarles]

Like I said no harsh side effects. One notable change in the last month is that I don't get up in the night to pee. Getting 5-6 hours straight sleep is great after being used to getting up a few times every night. We will see how this plays out in the coming months. I'll keep my progress updated but don't want to post every cycle.

[joancarles in reply to easeytiger]

Follow and improve And you will inform us at the moment that you consider it appropriate

[karlsiller in reply to easeytiger]

I have that same getting up several times a night having to pee problem. Glad to hear you won’t have to deal with that.

[tango65]

It seems that ipatasertib is beneficial in PC with PTEN loss.

urotoday.com/conference-hig...

I hope the combination of this drug with a PD-L1 inhibitor will be more effective.

[easeytiger]

Hi

Yes I was fully informed how both of these drugs were supposed to work. They are ipatasertib and atezolizumab. And yes I've been gene mapped which is why I was asked to take part in this early trial.

[Hidden]

I am pleased, so far so good for you

[dave2]

I also tested positive for a PI3K mutation (tumor tissue genomic analysis by FoundationOne). Were you also tested for level of PI3K protein expression in tumor tissue? This can be done using immunohistochemistry, as mentioned here: ncbi.nlm.nih.gov/pmc/articl...

[Kevinski65]

Where is this trial?

[easeytiger in reply to Kevinski65]

Sorry, I missed your post. The trial is at the Royal Marsden in London, UK

[GeorgeGlass]

Who should one talk to about immunology, a MO or a different doc who specializes in immunology. Is there such thing as an immunologist in the hospital or is that a naturopathic thing?