My husband checked in with Dr. Matthew Smith at Mass General yesterday to get a PSA test and see how things are going--see history below. We asked what PSA he hoped to see since my husband restarted Lupron again three months ago. His answer was "around 2 then hopefully going to undetectable." (His local urologist and internist had also predicted a quicker drop.) Dr. Smith will start him on Zytiga/Prenisone January, 2019.
When my husband checked the portal last night, his PSA result was 7. Ugh, decimal after the 7, not before. (His PSA dropped significantly a lot sooner when he first went on Lupron in 2014) He's going to talk to Dr. Smith's PA today and mention the PSA didn't drop as much as Dr. Smith predicted, so maybe we'll learn more about what this small PSA drop might mean.
Meanwhile, anyone out there care to comment on your own pre-Zytiga Lupron history or have any insights? It's hard to find men's histories to see how their ADT restart proceeded before they went on Zytiga. I will check back in with any feedback from Mass General, which can take some time.
Husband 70 yrs (74 now) pacemaker; Agent Orange 6-9/14: blood in urine; DRE suspicious biopsy 11/14: G 9 (4+5), PSA: 3.32 high Gleason, low PSA, PNI involved 11/14: Lupron taken for 33 mos and currently on Lupron again after a year hiatus.
6/15: 9 wks IMRT
4/18 0.98 6/18: 3-4 bone mets
8/28 9.0 Lupron re-started
11/27/18 (yesterday): 7.0
Zytiga planned 1/19