Husband has been on chemo/taxotere since July, 2015. He has tolerated it quite well and it seems to have kept his condition stable without progression, but the lowest his PSA has gotten, after a high of 115, is in the 40 range. He is also taking Eligard and Zometa and prednisone. After stretching out his chemo appointments last month to 5 weeks instead of 3 (due to vacation plans), he saw a sharp increase in PSA of 20 pts. Has another appt. next week to check on the PSA again. We may have to face the possibility that the taxotere is no longer working. Husband is wondering what's the longest period of time a Pca patient on this message board has been on chemo. And what are his options going forward if the chemo has lost effectiveness? Thanks.