Anyone considering going on mirapex I would advise a strong NO. After ramping up in dose for close to 20 years I find I am going nuts trying to get off of it. My doctor has me on a neurontin based med called Horizant ER. It seems to be helping the RLS but depresssion due to the lack of dopamine is becoming unbearable. I find myself in a constant state of dread except I don't know what I'm dreading. I have a lump in my throat and in my stomach it feels like there is a giant rock. I cry at the drop of a hat and can't stop sobbing. I have unexplained bouts of anger and my dog is avoiding me and won't wag her tail. Who could blame her. I keep eating and eating and am dreadfully overweight. I hate myself.