I had a private general health blood test as a checkup. My thyroid results are ok but I have a very high level of - Anti-Thyroglobulin Antibody. Its supposed yo be below 115 but my score is
237.
I do have mild symptoms of underactive thyroid, ie freezing cold hands, low heart rate - typically 46 (but I run a lot), and my typical oral temperature is 35c and in cold weather 34c. I have high cholesterol also, despite eating well.
I have no other symptoms. My tsh, t4, t3 are in range but t3 at low end. Any ideas thankyou.
Updates of other tests: (6 hrs fasting, taken 1130am)
For full Thyroid evaluation you need TSH, FT4 and FT3 tested
Also both TPO and TG thyroid antibodies tested at least once
Very important to test vitamin D, folate, ferritin and B12 at least once year minimum
About 90% of primary hypothyroidism is autoimmune thyroid disease, usually diagnosed by high thyroid antibodies
Autoimmune thyroid disease with goitre is Hashimoto’s
Autoimmune thyroid disease without goitre is Ord’s thyroiditis.
Both are autoimmune and generally called Hashimoto’s.
Low vitamin levels are extremely common when hypothyroid, especially with autoimmune thyroid disease
20% of autoimmune thyroid patients never have high thyroid antibodies and ultrasound scan of thyroid can get diagnosis
In U.K. medics hardly ever refer to autoimmune thyroid disease as Hashimoto’s (or Ord’s thyroiditis)
Recommended that all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test
This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)
Please add actual results
Plus any vitamin results you already have
Majority of Hashimoto’s patients will have high TPO and TG antibodies or just high TPO antibodies. But significant minority only have high TG antibodies
NHS currently doesn’t recognise only high TG antibodies as causing of a problem
However research suggests that high TG antibodies can cause “symptom burden”
Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose
IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results
In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg)
Only problem with folate, whenever I take it, as methyl folate Or b6 I get brain zap and cannot sleep. Even at a small dose of 25mcg. I can take it once a week but more than that i cannotsleep. It keeps waking me up. Like a spark plug of a car engine. It took me a while to figure it out. Its consistent. I am not even taking it as folic acid. Note: also taking individually or as a b complex has the same effect. Interestingly b2 gives me headaches. All the other b vitamins are fine.
It doesn't matter when I take it, morning or night. I think its cumulative and my body is struggling to process it. Its not a case of being 'wired', but not being able to sleep and then my day is non functional.
That's an impressive improvement from my typical 34 - 35c. I have been eating more regularly the last few weeks. Every 3hrs roughly and eating more porridge, magnesium oxide for improved transit. See my other post on this exacerbating muscle cramps.
I am considering that my 'undiagnosed hypothyroidism' maybe true but that its barely subclinical and made worse by gaving gilberts syndrome. Where I have impaired glucuronidation thus making my t3 conversion worse.
"T4 is converted into the more active T3 by the deiodinase system (D1, D2, D3) mainly in the liver, gut, brain, skeletal muscle and the thyroid gland itself.
T4 circulates through to the liver where 60% of it is converted into T3 through the glucuronidation and sulphation pathways during phase II of detoxification"
When both my body temperature had gone so low, my hemorroids had exacerbated and my tpo score increased, I was doing diy on my house for 2 weeks and eating about every 7 hrs. This fasting 'unintended' can worsen gilberts syndrome and thus glucuronidation. I didn't realise it would worsen it this much.
Of note: I wasn't running during this time. So no regular lymph movement which also normally would have helped my liver.
I recognise I am still undiagnosed and it may take putting myself through a fasting period to get poorer results for my next thyroid test, but for now I just need a breather from the tension I was in.
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High Thyroglobulin Antibodies
