High Vitamin B12 level

[megim71]

In the last year, the level of vitamin B12 in my blood has risen to 651.0 pg/ml; (ref. 183.3 - 505.0 pg/ml). Other parameters are basically fine

FT-3 4.15 pmol/l; (ref. 3.5-6.5)

Ferritin 6.96 μg/l; (ref <300)

Folic acid 5.02 ng/ml; (ref. 2.0-20.0)

Vitamin D3 18.76 ng/ml. (ref. 10-75)

Iron 4 µmol/l (ref. 7-26)

TSH varies throughout the year and I vary the therapy from 100 µg during the summer to 150 during the winter to keep it within the reference range.

Please write if anyone has a similar experience and what you think I should do next (because high vitamin B12 levels can also be caused by some types of cancer)

Thank you

[SeasideSusie Remembering]

megim71

Is your B12 high without taking any supplements? If so then your GP should be considering investigating why.

Other parameters are basically fine

How can they be when:

Ferritin 6.96 μg/l; (ref <300)

Iron 4 µmol/l (ref. 7-26)

If there are no typos and these are your actual levels, then this is iron deficiency. What is your doctor doing about this?

Vitamin D3 18.76 ng/ml. (ref. 10-75)

The Vit D Council, the Vit D Society and Grassroots Health all recommend a level of 100-150nmol/L (40-60ng/ml), with a recent blog post on Grassroots Health mentioning a study which recommends over 125nmol/L (50ng/ml).

Your Vit D level is low and needs supplementing.

[megim71 in reply to SeasideSusie]

1 week before taking a blood sample, I wasn't taking any supplements. 5 years ago I had a myomectomy and since then I am suffering from anemia. When I stop taking iron supplements, my blood iron level drops very fast.

I will start with Vit D supplementing.

Thank you for your advice

[SlowDragon Administrator]

Folate is also very low

That’s a huge change in dose of levothyroxine. Suggest you try 125mcg all year. It takes 6-9 months to adjust to any dose change

If you keep changing dose between winter and summer, your body is never settled…..no wonder vitamins are so terrible

What vitamin supplements are you currently taking

High B12 can be deceiving

Paradoxical B12 deficiency with hypothyroidism

b12oils.com/paradoxical.htm...

suggest you consider starting on vitamin B complex to improve low folate

This can help keep all B vitamins in balance

Difference between folate and folic acid 

chriskresser.com/folate-vs-...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule) 

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate methyl folate supplement

[megim71]

Thank you for your advice. I will try not to change the dose of levothyroxine for at least 6 months.

Isn't it better if I start taking only B9 vitamins?