A frequently asked question here is whether home-draw blood tests using lancets to obtain small amounts of blood are comparable to the standard large samples taken from our veins.
Whilst we have had quite a number of people report that when they had two tests done very close in time, the results were almost always just about perfectly in agreement, it is good to see a paper specifically investigating this.
Shame the number involved wasn't much, much greater.
Obstet Gynecol. 2019 Jan 8. doi: 10.1097/AOG.0000000000003066. [Epub ahead of print]
Concordance of Fingerstick and Venipuncture Sampling for Fertility Hormones.
Burke EE1, Beqaj S, Douglas NC, Luo R.
Minimally invasive fingerstick sampling allows testing of reproductive hormone levels at home, providing women with increased access to tests that can screen for conditions such as polycystic ovarian syndrome, primary ovarian insufficiency, and pituitary and thyroid dysfunction.
We present a measurement procedure comparison study of matched venipuncture and fingerstick samples from 130 women aged 18-40 years, tested on menstrual cycle day 3. Samples were measured for anti-müllerian hormone, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), testosterone, thyroid-stimulating hormone (TSH), and free thyroxine (T4) levels. Samples were tested using U.S. Food and Drug Administration-cleared immunoassays, with a modified reconstitution step for fingerstick samples.
Venipuncture and fingerstick hormone values were concordant and linear across all assay ranges. There was no evidence of systematic bias across the assay ranges, and bias measures were below recommended guidelines. The correlation between venipuncture and fingerstick was between 0.99 and 1.0 for each hormone. Each assay displayed a high degree of precision (less than 13% coefficient of variation) and a high level of accuracy (average recovery equaled 95.5-102.3%).
Venipuncture and fingerstick samples can be used interchangeably to measure anti-müllerian hormone, E2, FSH, LH, PRL, testosterone, TSH, and free T4 levels. Fingerstick sampling provides doctors and women more convenient testing options.
The study was sponsored by Modern Fertility.