I have just read Hugh A. Hamilton's book "Impaired Sensitivity to Thyroid Hormone (Thyroid Hormone Resistance)" which focuses on the subject of ISTH - Impaired Sensitivity to Thyroid Hormon and found it to be really good read. Most of it is explained in laymans terms and there are references at the end of each chapter to follow up on.
Hugh happens to be our very own Sandy12 who doesn't appear here much but I believe he is still a member.
Yes, I read this a while ago too - after spotting Sandy mentioning it on another post from way back. It sounded to me like it might be the explanation for me not doing very well on NDT, even though my T3 is near the top of the range. I've therefore started on T3 only. It's early days yet, but there have been some very positive signs so far. I'm extremely grateful to Sandy for this book as it may be that I'm finally on the right path with this. 
I really need to read this, but I believe it's only available as an e-book and only compatible with kindle?
You can get a free Kindle reader/emulator for the PC from Amazon.
Thank you Angel_of_the_North - will investigate
several other authors eg p robinson, dr. lowe etc have mentioned thyroid resistance but hugh's book is the only one that i have read so far that focuses entirely on this subject and explains it in simple language. there's lots of technical papers out there on the subject but they are deeply technical, meant for dr's/endos/medical researchers etc.
If you can find a used copy of John Lowe's original book, The Metabolic Treatment of Fibromyalgia, you will find it gives great attention to this problem. It is hard to find at a realistic price though - I was lucky - and it is a huge medical textbook. At some point this year I intend set aside time to go through it more thoroughly.
hillwoman - i know of that book, does that go into great technical medical detail or does it also provide simple explanations too ?
Well, I would describe it as clearly written, but inevitably it is techically detailed.
thx, i may well save up for it.
Having had Hashimotos for 25 years and becoming more and more ill and disabled with more labels given such as CFS, FIBRAMYALGIA,SJOGRENS, JHS, etc etc I decided to do my research and discovered I had ISTH ( impaired sensitivity to Thyroid hormone ) I had a reverse T3 of 28, auric acid levels sky high, insulin sky high, Cholesterol problems, in fact all my bloods were out of range. So I paid privately for a series of bloods and went to my doctor. His answer ? To throw yet more T4 Levothyroxine at me !!!! I realised that I was simply NOT converting T4 to active T3 and read above book. Dr Lowe was and still is in my opinion the very best Thyroid doctor ever. He advocated that a small percentage of patients would only ever get better on T3 medication only ( he himself took something like 150mcg T3 daily ) and was in perfect health until his ( accidental ) death. And this is route I've now embarked on. I believe that in a short while all my bloods will right themselves. The weight that has gone up and up ( despite having been skinny all my life previously) I can't wait to tell of my progress. Why oh why do doctors still insist Levothyroxine is a one size fits all ? And why are drug companies allowing wed to rip off NHS charging £900 for 100 tablets of T3 ? When 100 of same tablets can be purchased from Turkey for £1.20 ? And why don't the same doctors realise that fix the thyroid and you will save billions of £s for NHS. and not just NHS, also in disability benefits too. And finally why in 2017 do we have to be responsible for our own health and pay private fees for blood tests that should be available to all, and have to purchase privately what is a relatively cheap drug to feel well again.
thyroid hormone resistance syndrome
Peripheral thyroid hormone resistance 
ATA document on Thyroid Hormone Treatment
