Why Efforts to Harmonize Testing Are Critical to Patient Care
I had added this to another post and I'm afraid it got lost. There are some interesting statements in this article that Thyroid Patients should be aware of. PR
"Based on the functional interrelationship of the hypothalamus, pituitary gland, and thyroid, TSH should be elevated if the thyroid gland is not producing adequate thyroid hormone, and suppressed if it is producing too much (Figure 1). Today, however, we are beginning to realize that this well-established paradigm for TSH synthesis and release is an oversimplification."
"Although laboratory measurement of serum TSH is an essential tool for diagnosing and managing various thyroid disorders, the laboratory medicine community has long recognized that immunoassays used to measure the hormone are yet another source of variability in patients’ results."
"The upper limit of euthyroidism with first-generation TSH assays was approximately 10 mIU/L, but with the introduction of second- and third-generation assays it fell to approximately 5 mIU/L. The most likely reason for this change was the reduced cross-reactivity afforded by the monoclonal antibodies used in the newer assays."
"there is growing consensus that one TSH reference interval does not fit all."