Hi Daniel, When I first of MSM I was advised it worked for about half the people and that is the thing about supplements. It seems that methylation and sulfation are necessary components but I can't explain it. If either are problematic it may interfere with nutrients. That's why it becomes trial and error. Milk thistle or silymarin is good for the liver as is alpha lipoic acid. Our livers do a lot of work for us and take the brunt of most toxins so we need supplements that help with detox.
Milk thistle is for the liver I take it because I have no gallbladder and it aids the liver, which already has a powerful job to do anyway. The others I have no idea, sorry.
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