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Wednesday's Word
It is released predominantly by injured hepatocytes (cells of the liver), making it usually more prone to be seen in hepatitis. PBC is primarily a disease of the bile duct cells (biliary epithelial cells). The ALT can also be elevated in overlap as well as Urso non responders.
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Wednesday's Word
[i]Autoimmune (AIH)[/i]
This is an autoimmune disease where the attack is on the hepatocytes (cells of the liver) rather than the biliary cells (bile ducts). It presents very differently and is treated very differently as well.
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Wednesday Word
It is released more so by the [u][i]hepatocytes -(liver cells) [/i][/u] so it's associated more with hepatitis rather than PBC. ALT can be elevated in both non responders to Urso and overlap diseases. When the ALT is significantly elevated, it always warrants investigation by your doctor.