Latest Results...

[KT304]

Hi All

Latest results by Blue Horizon:

Biochemistry

CRP 1.50 <3.0 mg/L

Ferritin 78.5 20 - 150 ug/L

Thyroid Function

Free T4 L 1.02 12 - 22 pmol/L

Free T3 3.76 3.1 - 6.8 pmol/L

TSH L 0.11 0.27 - 4.20 IU/L

T4 Total L 9.1 64.5 - 142.0 nmol/L

Immunology

Anti-Thyroidperoxidase abs H 60.7 <34 kIU/L

Anti-Thyroglobulin Abs 28.5 <115 kU/L

Vitamins

Vitamin B12 H 732 Deficient <140 pmol/L

Insufficient 140 - 250

Consider reducing dose >725

Serum Folate 13.82 10.4 - 42.4 nmol/L

Current dosage is 50mcg of T3 Tiromel taken when I go to bed. Had previously tried T4 given by my GP, 25mcg dose, lasted 7 days before I couldn't take any more. Waited a week to clear some T4, then started back on T3 very slowly and have been on 50mcg for at least 6 weeks. It took a while to get to 50 from 37.5, but have been stable, if not still undereplaced on 50. Wanted to wait a while before increase. Shall I go for another 25mcg?

I was not expecting the anti-thyroidperoxidase to be high though.

Have some new issues, namely very bad spots/acne, which is appearing in various places such as arms, chest, neck, head, extreme face. Wrists and thumbs are very sore. I've put on another half a stone which is not good. Hair very much dying, and falling out daily.

I saw a new GP today, and apart from being severely lectured on my self medication, has referred me at my insistence to the Endo at my local hospital due to the antibodies. Does anyone have any info on T3 that I can print and take with me, anything related to when NHS will prescribe T3?

All help gratefully received

[Clutter]

KT304, thyroid peroxidase antibodies are positive for autoimmune thyroid disease (Hashimoto's). 100% gluten-free diet can be helpful in managing Hashimoto's and reducing antibodies.

chriskresser.com/the-gluten...

thyroiduk.org.uk/tuk/about_...

TSH and FT4 are low because you are taking T3 only. FT3 is low in range so you need to increase dose. 25mcg may be too much, I suggest 12.5mcg initially, and up to 18.75mcg if necessary. Hold at 18.75mcg for 4-6 weeks and have a FT3 test before increasing further.

thyrophoenix.com/adjusting_...

B12 and folate are good. If you are supplementing I would continue on the same dose to maintain levels.

NHS endos can prescribe T3 on an individual patient basis unless their CCG or hospital has prohibited prescribing of T3. There is evidence that thyroidless patients and some with DIO2 gene impairing T4 to T3 conversion may do better with Levothyroxine (T4) + T3 combination therapy but I'm not aware of any research demonstrating efficacy or safety of T3 monotherapy which is usually only prescribed to thyCa patients awaiting RAI and who are switched to T4 after. Having an allergy to all forms of Levothyroxine might persuade an endo that T3 monotherapy is warranted.