If low vitamin D is associated with higher TSH receptor antibodies, does this suggest that raising vitamin D just might help to stop them rising further? Or, at the extremes of optimism, actually reduce them?
Endocr Pract. 2014 Nov 4:1-23. [Epub ahead of print]
Low Vitamin D Status is Associated with Increased Titers of Thyroid Stimulating Hormone Receptor Antibodies in Graves' Disease.
Zhang H, Liang L, Xie Z.
Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Background: Vitamin D deficiency has been reported to link with a variety of autoimmune diseases. However, the relationship between the thyroid autoimmunity in Graves' disease (GD) and vitamin D deficiency is unclear. The goal of this study was to determine whether increased titers of thyroid autoantibodies were associated with vitamin D deficiency in GD patients.Subjects: Seventy patients with GD and seventy matched control subjects were recruited to our study. The levels of 25-hydroxyvitamin D [25(OH)D], calcium, parathyroid hormone (PTH), free triodothyronine (FT3), free thyroxine (FT4) thyroid-stimulating hormone (TSH), thyrotrophin receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in the serum collected from these patients and controls were examined.Results: The levels of 25(OH)D in serum from TRAb positive GD patients were significantly lower than that from healthy controls or TRAb negative patients. However, the levels of PTH in serum were increased in TRAb positive GD patients compared to control subjects. The rates of vitamin D deficiency (defined as serum 25(OH)D<50 nmol/L) in TRAb positive GD patients were significantly higher than that observed in healthy controls or TRAb negative GD patients. The levels of 25(OH)D in serum were inversely correlated with TRAb titers in serum in TRAb positive GD patients. However, our results did not show a correlation between the levels of 25(OH)D and the levels of TPOAb, TGAb, FT3, FT4, and TSH.
Conclusion: Low vitamin D status is associated with increased titers of TRAb in Graves' disease, suggesting a possible link between vitamin D status and increased thyroid autoimmunity in GD patients.
Graves' disease; Thyroid autoimmunity; Vitamin D
PMID: 25370319 [PubMed - as supplied by publisher]