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advice on clinical trial
lupron,xgevia and 12 rounds of chemo and
zytiga
. PSa dropped to 3 but now uo to 8. 4 months on
zytiga
. SOC treatment options are xtandi, more chemo orR223. Doc recommends trial at U of Chicago , phase 1/1b so all patients get Rucaparib (PARP inhibitor) and Nivolumab .
lupron,xgevia and 12 rounds of chemo and
zytiga
. PSa dropped to 3 but now uo to 8. 4 months on
zytiga
. SOC treatment options are xtandi, more chemo orR223. Doc recommends trial at U of Chicago , phase 1/1b so all patients get Rucaparib (PARP inhibitor) and Nivolumab .
Eabradley
in
Advanced Prostate Cancer
5 years ago
New member with moldy bones (metastases)...here to get involved...
Besides the orchiectomy that I got just prior to the Lupron wearing off, I went on
Zytiga
and went back to a normal life with no side effects except for hot flashes, but then went castrate resistant in just 12 months.
Besides the orchiectomy that I got just prior to the Lupron wearing off, I went on
Zytiga
and went back to a normal life with no side effects except for hot flashes, but then went castrate resistant in just 12 months.
MoldyBones
in
Advanced Prostate Cancer
5 years ago
Xtandi or Zytiga or Yonsa? Pros, Cons, Side Effects? What about Erleada?
What are the pros and cons of Xtandi (enzalutamide) and
Zytiga
(abiraterone acetate) and Yonsa another formulation of abiraterone acetate? Particularly regarding side effects. It seems the docs never do a good job of explaining side effects, until they are upon you.
What are the pros and cons of Xtandi (enzalutamide) and
Zytiga
(abiraterone acetate) and Yonsa another formulation of abiraterone acetate? Particularly regarding side effects. It seems the docs never do a good job of explaining side effects, until they are upon you.
cesanon
in
Advanced Prostate Cancer
5 years ago
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Any relation between PCa and Granuloma Annulare?
I am on Lupron,
Zytiga
and prednisone and now have a negligible PSA. My question has to do with granuloma annulare, supposedly a harmless skin disorder. Although it is only supposed to last for a few years I have had it for probably 15 years.
I am on Lupron,
Zytiga
and prednisone and now have a negligible PSA. My question has to do with granuloma annulare, supposedly a harmless skin disorder. Although it is only supposed to last for a few years I have had it for probably 15 years.
KJMinPhx
in
Advanced Prostate Cancer
5 years ago
Workable strategies for obtaining low-cost ZYTIGA (abiraterone) from outside the US.
ZYTIGA
(abiraterone) [i]"is now generic and is available in USA for $2400 a month, In Europe for $500 to $ 700 a month and in India for $150 to $200 a month."[/i] LearnAll Does anyone have any workable strategies for obtaining low cost
ZYTIGA
(abiraterone) from outside the US?
ZYTIGA
(abiraterone) [i]"is now generic and is available in USA for $2400 a month, In Europe for $500 to $ 700 a month and in India for $150 to $200 a month."[/i] LearnAll Does anyone have any workable strategies for obtaining low cost
ZYTIGA
(abiraterone) from outside the US?
cesanon
in
Advanced Prostate Cancer
5 years ago
RP + ADT+ IMRT Report
I have
zytiga
and Prednisone on hand and was prescribed it at a LA consult with Prostate Oncology Specialists ( Scholz, Lam, and Turner) but Dallas surgeon and oncologist say that I will not get a real boost from it and it is not without side effects and risks."
I have
zytiga
and Prednisone on hand and was prescribed it at a LA consult with Prostate Oncology Specialists ( Scholz, Lam, and Turner) but Dallas surgeon and oncologist say that I will not get a real boost from it and it is not without side effects and risks."
TEBozo
in
Advanced Prostate Cancer
5 years ago
After Scans Regimen Staying Same
Had 6 month scans and there was moderate improvement in metastasis and in lymph nodes....despite PSA going up oncologist said I was still early in treatment with lupron and
zytiga
and would monitor closely with new scans in September...many options if needed....any thoughts?
Had 6 month scans and there was moderate improvement in metastasis and in lymph nodes....despite PSA going up oncologist said I was still early in treatment with lupron and
zytiga
and would monitor closely with new scans in September...many options if needed....any thoughts?
SPEEDYX
in
Advanced Prostate Cancer
5 years ago
Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells.
There appears to be synergy between statins &
Zytiga
(Abiraterone): "We determined that androgen biosynthesis inhibitors simvastatin, atorvastatin, and ketoconazole directly inhibit growth, migration, and colony formation of LNCaP C-81 cells, which exhibit de novo androgen biosynthesis, with simvastatin
There appears to be synergy between statins &
Zytiga
(Abiraterone): "We determined that androgen biosynthesis inhibitors simvastatin, atorvastatin, and ketoconazole directly inhibit growth, migration, and colony formation of LNCaP C-81 cells, which exhibit de novo androgen biosynthesis, with simvastatin
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Oliparib without the BRCA gene
My husband has not had success with any of the standard of care treatments, docetaxel, twice,
zytiga
, xrtandi, radium 223 and cabazaiaxel .He has a rising PSA currently of 178 and is faced with a decision of continuing to qualify for the AC225 clinical trial( his blood levels are there yet) or trying
My husband has not had success with any of the standard of care treatments, docetaxel, twice,
zytiga
, xrtandi, radium 223 and cabazaiaxel .He has a rising PSA currently of 178 and is faced with a decision of continuing to qualify for the AC225 clinical trial( his blood levels are there yet) or trying
joann48
in
Advanced Prostate Cancer
5 years ago
PROACTIVE
I have been on
Zytiga
for 18 months. PSA UNDETECTABLE at 0.01. Had growth in neck at C3 which grew from 5mm to 20mm over 6 months. Recently hit that with 35 Gys of stereotactic radiation. No more intermittent pains in neck. I want to keep on
Zytiga
as long as possible.
I have been on
Zytiga
for 18 months. PSA UNDETECTABLE at 0.01. Had growth in neck at C3 which grew from 5mm to 20mm over 6 months. Recently hit that with 35 Gys of stereotactic radiation. No more intermittent pains in neck. I want to keep on
Zytiga
as long as possible.
nobaday
in
Advanced Prostate Cancer
5 years ago
Cabazitaxel,Cytoxan or Comfort Care after dismissal from Lu PSMA Vision Trial
Since then, we have been through Provenge,
Zytiga
, Xstandi, Docetaxel (5 sessions), and he still is receiving Lupron and Xgeva. Out of all the treatments, only the Docetaxel's side effects became unbearable and I am quite certain he would have died if he stayed on it.
Since then, we have been through Provenge,
Zytiga
, Xstandi, Docetaxel (5 sessions), and he still is receiving Lupron and Xgeva. Out of all the treatments, only the Docetaxel's side effects became unbearable and I am quite certain he would have died if he stayed on it.
Jrb70
in
Advanced Prostate Cancer
5 years ago
Itraconozole and Zytiga
Is anyone out there using this combination? I'm doubly interested as it turns out Itra is also effective in basal and squamous cell malignancies of which I have many...which the dermo wants only to cut away at. I'm not so sure about this approach given I may have a cutaneous DNA repair flaw. Turns out
Is anyone out there using this combination? I'm doubly interested as it turns out Itra is also effective in basal and squamous cell malignancies of which I have many...which the dermo wants only to cut away at. I'm not so sure about this approach given I may have a cutaneous DNA repair flaw. Turns out
Jbooml
in
Advanced Prostate Cancer
5 years ago
Need advice if I should do Docetaxel/Lucrin even when PSA continues to drop to 0.41
Have been on
Zytiga
+ Prednisolone,Lucrin,Zometa for the last 6 months. PSMA and FDG PET/CT showed a lot of improvement. Oncologist is suggesting that I seriously look into doing docetaxel +Lucrin to increase longer overall survival based on New England Journal, August 20th, 2015 .
Have been on
Zytiga
+ Prednisolone,Lucrin,Zometa for the last 6 months. PSMA and FDG PET/CT showed a lot of improvement. Oncologist is suggesting that I seriously look into doing docetaxel +Lucrin to increase longer overall survival based on New England Journal, August 20th, 2015 .
bellyhappy
in
Advanced Prostate Cancer
5 years ago
Has anyone had treatment for lu177 at Homburg Germany and how did it go.?
I am thinking about going since I have failed
Zytiga
and other treatments.
I am thinking about going since I have failed
Zytiga
and other treatments.
oldcars
in
Advanced Prostate Cancer
5 years ago
XTANDI UPDATE
Start
Zytiga
on July 14. A summary of my treatment history since diagnosis in 1999 at age 55 is in my profile. Hope this is helpful to some of you wondering what to expect and what the possibilities are. May the force be with you.
Start
Zytiga
on July 14. A summary of my treatment history since diagnosis in 1999 at age 55 is in my profile. Hope this is helpful to some of you wondering what to expect and what the possibilities are. May the force be with you.
chascri
in
Advanced Prostate Cancer
5 years ago
Overall Survival Over Time
It looks to me like the "don't use early
Zytiga
" curve is heading towards 40% at 5 years. This would reflect the benefit gained from newer drugs becoming available. The "early
Zytiga
" curve is heading towards the high 50s possibly as high as 60%.
It looks to me like the "don't use early
Zytiga
" curve is heading towards 40% at 5 years. This would reflect the benefit gained from newer drugs becoming available. The "early
Zytiga
" curve is heading towards the high 50s possibly as high as 60%.
tom67inMA
in
Advanced Prostate Cancer
5 years ago
Shoulder Muscle Pain. Statins?
Feeling like both shoulders are pulling with some pretty slight movement. Taking Crestor and Zetia. Does anyone have any recommendations about dealing with the pain? I need the statins as I'm CABG x3 recently. Call is already into cardiologist.
Feeling like both shoulders are pulling with some pretty slight movement. Taking Crestor and Zetia. Does anyone have any recommendations about dealing with the pain? I need the statins as I'm CABG x3 recently. Call is already into cardiologist.
CoachBrown
in
British Heart Foundation
5 years ago
How much prednisone is needed with abiraterone?
This is a frequently asked question among men using
Zytiga
. The answer is highly individual. The benefits and side effects have to be monitored. There is no "one size fits all." https://pcnrv.blogspot.com/2019/06/how-much-prednisone-is-needed-with.html
This is a frequently asked question among men using
Zytiga
. The answer is highly individual. The benefits and side effects have to be monitored. There is no "one size fits all." https://pcnrv.blogspot.com/2019/06/how-much-prednisone-is-needed-with.html
Tall_Allen
in
Advanced Prostate Cancer
5 years ago
Zytiga and muscle weakness
My Dad has been on
Zytiga
since feb. his strength has gone down hill. Blood work and every test he has taken is good. Either A. The cancer in the bones is weakening him to the point of not walking. B.
Zytiga
side effects are this. Any thoughts
My Dad has been on
Zytiga
since feb. his strength has gone down hill. Blood work and every test he has taken is good. Either A. The cancer in the bones is weakening him to the point of not walking. B.
Zytiga
side effects are this. Any thoughts
Edbl
in
Advanced Prostate Cancer
5 years ago
Prednisone withdrawal ?
My last
Zytiga
and prednisone were last Friday. Then Sunday and today I had fatigue worse than during chemo. Could this be prednisone withdrawal? I was only taking 5 mg/day, so I saw no need to taper. But I have been on it for 18 months. Anyone have similar experience?
My last
Zytiga
and prednisone were last Friday. Then Sunday and today I had fatigue worse than during chemo. Could this be prednisone withdrawal? I was only taking 5 mg/day, so I saw no need to taper. But I have been on it for 18 months. Anyone have similar experience?
Canoehead
in
Advanced Prostate Cancer
5 years ago
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