I was diagnosed six months ago, no Mets to bone, but metastasis to distant lymph nodes like retro peritoneal. I am on Lupron, Zytiga and prednisone and now have a negligible PSA. My question has to do with granuloma annulare, supposedly a harmless skin disorder. Although it is only supposed to last for a few years I have had it for probably 15 years. I had it biopsied 10 years ago and they confirmed it was just granuloma annulare. The issue is that I have noticed that It has gotten more bright and pronounced, and larger ridges in the last year or two. Not too uncomfortable but it itches some. It seems to me that as the prostate cancer got worse so did it. I asked my MO and he said there is no relation, but I can’t help but think there is. I have done a med literature search and found two very loose case notes and no studies.
So: has anyone else had any problems with skin issues like this? Any thoughts?
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KJMinPhx
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Purely anecdotal, but at the time my PCa was progressing before I caught it, I began having occurrences of eczema, and a mole and a few squamous cell growths pop up on my head out of nowhere. I think it was a sign of a weakened immune system, that helped allow PCa progression. After I improved my diet, these dermatological anomalies abated, and I don't get eczema anymore.
I had something that a biopsy 'surmised' that it "could be GA in resolution." Mine were round red blotches that kinda resembled ringworm. I spent numerous hours on the NET trying to find something that looked 'exactly' like what had with little success. Visited five dermatologists before the last one, a young Chinese doctor at Bangkok Hospital who looked at it for a few seconds and determined that it was 'disseminated porokeratosis'. She said that it is a rare skin condition that they 'think' is caused by sun exposure. I had some of the larger ones burned off with liquid nitrogen by a dermatologist at UCI which was a big mistake...he burned so deep that I still have significant scars after three years.
Here is an anecdotal case [1], but it is the only paper out of 186,386 prostate-related papers on PubMed. I would disregard it.
Do you have symptoms of the Metabolic Syndrome? How is your thyroid? Immune system?
I was interested in [2], where granuloma annulare was successfully treated with a 5-lipoxygenase inhibitor and vitamin E. A number of us use a 5-LOX inhibitor such as [3] for PCa. My preferred vitamin E for PCa is DeltaGold tocotrienols [4].
Granuloma annulare associated with prostate carcinoma.
Akyol M1, Kiliçarslan H, Göze F, Emre S.
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Abstract
Granuloma annulare occurs as an idiopathic and benign condition, although it may be associated with some neoplasms. We describe a 60-year-old man with granuloma annulare on dorsal hands who developed prostate carcinoma. To the best of our knowledge, this is the first case report of granuloma annulare with prostate carcinoma. Granuloma annulare, especially in older age groups, may be classified as a sign of various carcinomas.
Treatment of disseminated granuloma annulare with a 5-lipoxygenase inhibitor and vitamin E.
Smith KJ1, Norwood C, Skelton H.
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Abstract
Histologically, granuloma annulare (GA) is a common non-infectious necrobiotic granulomatous reaction pattern that correlates with a number of different, but relatively specific clinical presentations. The cause or causes of GA are unknown: when localized, it is usually self-limiting, but it may be persistent when disseminated. We present three women who had had disseminated GA for more than 1 year. One patient had previously been treated with isotretinoin with no response. All three patients were treated with vitamin E 400 IU daily and zileuton 2400 mg daily. All responded within 3 months with complete clinical clearing. The anti-inflammatory and immune regulatory effects of vitamin E and zileuton may be an effective treatment in some patients with prolonged disseminated/generalized GA.
Weird I just developed a small dark brown circle on my left arm. Could it be granuloma annulare or is it related to my other melanoma? I will see my Dermatologist next week on Wed. 7/24.
Dermatologist's creed: If it's wet, make it dry. If it's dry, make it wet.
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