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Promising, especially for people with LBD mutation: NEJM Evidence publishes results from Phase I/IIa CYPIDES trial with ODM-208
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
Maxone73
in
Advanced Prostate Cancer
8 months ago
Clinical trial NCT05898399: for BRCA (ATM as well I suppose) mutations
Study of ART6043 in Advanced/Metastatic Solid Tumors Patients This company is also developing an interesting ATR inhibitor for ATM mutations https://classic.clinicaltrials.gov/ct2/show/NCT05898399
Study of ART6043 in Advanced/Metastatic Solid Tumors Patients This company is also developing an interesting ATR inhibitor for ATM mutations https://classic.clinicaltrials.gov/ct2/show/NCT05898399
Maxone73
in
Advanced Prostate Cancer
8 months ago
Tuesday's 'Tip'
I've decided to incorporate some of Dr. Jones's wisdom into our Tuesday's 'Tips' These are all from his book [u][i]The Definitive Guide for Patients Who Have Primary Biliary Cholangitis.[/i][/u] This an amazing source of information on PBC from a world leading expert. I strongly encourage everyone
I've decided to incorporate some of Dr. Jones's wisdom into our Tuesday's 'Tips' These are all from his book [u][i]The Definitive Guide for Patients Who Have Primary Biliary Cholangitis.[/i][/u] This an amazing source of information on PBC from a world leading expert. I strongly encourage everyone
DonnaBoll
Administrator
in
PBC Foundation
2 months ago
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Alk phos on Xeloda
Moms just started her 3 cycle today of xeloda. So she’s been on it 6 weeks. Her T bili is normal her ast and alt are normal . But her Alk phos is up. Her doctor said they would continue to monitor it. Anyone else have this elevate on Xeloda ? Thanks so much!
Moms just started her 3 cycle today of xeloda. So she’s been on it 6 weeks. Her T bili is normal her ast and alt are normal . But her Alk phos is up. Her doctor said they would continue to monitor it. Anyone else have this elevate on Xeloda ? Thanks so much!
Flower1513
in
SHARE Metastatic Breast Cancer
8 months ago
Confusing news from oncologist
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
StayingSTRNG
in
Advanced Prostate Cancer
8 months ago
Pain management change of meds.
Hi there , after a recent visit with a pain management doctor I have been ask the try some new medication called Celecoxib instead of Naproxen has anyone else use this medicine for chronic pain they said in a newish drug so not sure what to expect side affects etc...a also take pregablain 75mg day dose
Hi there , after a recent visit with a pain management doctor I have been ask the try some new medication called Celecoxib instead of Naproxen has anyone else use this medicine for chronic pain they said in a newish drug so not sure what to expect side affects etc...a also take pregablain 75mg day dose
Rob172
in
Fibromyalgia Action UK
5 months ago
SBRT #4
Update on yesterday's SBRT #4. The machine that is treating me (Varian Edge) takes two revolutions to administer the fraction. They line you up with lasers and images before, track the fiducials during the rotation (and the machine automatically holds the beam if you and/or your prostate move out of
Update on yesterday's SBRT #4. The machine that is treating me (Varian Edge) takes two revolutions to administer the fraction. They line you up with lasers and images before, track the fiducials during the rotation (and the machine automatically holds the beam if you and/or your prostate move out of
ToolBeltZia
in
Prostate Cancer Network
8 months ago
B12 Folate and Ferritin
I have got a Vitamin D supplement. Can anybody recommend a brand of B12, Folate and Ferritin?
I have got a Vitamin D supplement. Can anybody recommend a brand of B12, Folate and Ferritin?
foamfollower
in
Thyroid UK
5 months ago
Have'nt had a panic attacks in a long time but when it attacked it hit me hard for some reason.
hey everyone, So lastnight i decided to go out for a few drinks with a friend. Everything was fine at first, but then we left from the location that we were decided to go home while he's on his way to drop me home I feel a panic attack coming in but strong. I felt like I couldn't breathe and my heart
hey everyone, So lastnight i decided to go out for a few drinks with a friend. Everything was fine at first, but then we left from the location that we were decided to go home while he's on his way to drop me home I feel a panic attack coming in but strong. I felt like I couldn't breathe and my heart
Johnnie1234
in
Anxiety Support
2 months ago
Cirrhosis and gallstones
Hi Everyone. I have yet another question [sorry!] I have cirrhosis, and gallstones were picked up in my last Cat Scan. Just wondering if gallstones can increase liver enzymes in blood tests? Thank you!
Hi Everyone. I have yet another question [sorry!] I have cirrhosis, and gallstones were picked up in my last Cat Scan. Just wondering if gallstones can increase liver enzymes in blood tests? Thank you!
puddy68
in
British Liver Trust
2 months ago
wanting to do this trip
I really want to do this trip. I don’t want my anxiety to keep taking over my life. I did have some zofran on hand but now I’m reading I can’t take that with my Zoloft?
I really want to do this trip. I don’t want my anxiety to keep taking over my life. I did have some zofran on hand but now I’m reading I can’t take that with my Zoloft?
Daisy425
in
Anxiety and Depression Support
2 months ago
confused whether to go ahead with laparoscopy
31 year old female Hi everyone I am due to have a diagnostic laparoscopy in 2.5 weeks. I am so nervous about the procedure and unsure whether to go ahead. My pain over the last few months has been manageable and my periods are ok. I don’t know whether I’m getting used to the pain. I have changed my
31 year old female Hi everyone I am due to have a diagnostic laparoscopy in 2.5 weeks. I am so nervous about the procedure and unsure whether to go ahead. My pain over the last few months has been manageable and my periods are ok. I don’t know whether I’m getting used to the pain. I have changed my
Penguinpal
in
Endometriosis UK
5 months ago
I am so tired of anxiety and panic attacks
I have had this for many years. I tried many meds but didn’t help. Every morning the panic comes. I lie down sometimes for hours. Breathe , take clonapepam. i force myself to go to activities but don’t enjoy them cause of anxiety. Feels like a lump in my throat today I feel sad. What is the use
I have had this for many years. I tried many meds but didn’t help. Every morning the panic comes. I lie down sometimes for hours. Breathe , take clonapepam. i force myself to go to activities but don’t enjoy them cause of anxiety. Feels like a lump in my throat today I feel sad. What is the use
TaliaTalia5
in
Anxiety and Depression Support
2 months ago
shift work
Hi all, so glad I found this group.Diagnosed 10 years ago and have always worked night shifts, I’m now being told I must work 12 hour days (7-7.30)as well even though occupational health advise nights only, stiffness and pain in the mornings make it impossible to be anywhere for 7am in the morning, nevermind
Hi all, so glad I found this group.Diagnosed 10 years ago and have always worked night shifts, I’m now being told I must work 12 hour days (7-7.30)as well even though occupational health advise nights only, stiffness and pain in the mornings make it impossible to be anywhere for 7am in the morning, nevermind
Nitenurse63
in
NRAS
5 months ago
Endo in bowel tips
I was just wondering if anybody could help in regards to having endometriosis in their bowel, as I've found it quite hard to find out about it when researching. My surgeon found it on the outside of my bowel, and I am seeing a colon specialist to see if it has entered my bowel. I was just wondering if
I was just wondering if anybody could help in regards to having endometriosis in their bowel, as I've found it quite hard to find out about it when researching. My surgeon found it on the outside of my bowel, and I am seeing a colon specialist to see if it has entered my bowel. I was just wondering if
shaqshuka101
in
Endometriosis UK
5 months ago
What ever happened?
Why can't I get my fat arse out of my room and bed? I wrote some lists out for what we need to do around the house and remind us what to do on a daily and weekly basis once the deep clean is done, Every time I plan anything I just get waylaid and all that gets done is, tv oh yeah and crap snacking!
Why can't I get my fat arse out of my room and bed? I wrote some lists out for what we need to do around the house and remind us what to do on a daily and weekly basis once the deep clean is done, Every time I plan anything I just get waylaid and all that gets done is, tv oh yeah and crap snacking!
Debsdelight72
in
Fibromyalgia Action UK
5 months ago
constipation help
hope you knowledgeable people can help me. I was shouted at by my gp and bought to tears. She insisted I follow her Plan. 3 docusate and 1 fybogel sachet daily. To ignore what other drs have said. I began with this on 1st March, I’m now on day 6, have still not opened my bowels. I have terrible
hope you knowledgeable people can help me. I was shouted at by my gp and bought to tears. She insisted I follow her Plan. 3 docusate and 1 fybogel sachet daily. To ignore what other drs have said. I began with this on 1st March, I’m now on day 6, have still not opened my bowels. I have terrible
Laxido21
in
IBS Network
5 months ago
NICE guideline on B12 Deficiency diagnosis and monitoring in over 16s
The Vitamin B12 Deficiency Guideline in Over 16's has been published.
What does this mean for those with Pernicious Anaemia whether formally diagnosed or not?
What does it mean with those struggling to get sufficiently frequent treatment for their B12 deficiency?
What does
The Vitamin B12 Deficiency Guideline in Over 16's has been published.
What does this mean for those with Pernicious Anaemia whether formally diagnosed or not?
What does it mean with those struggling to get sufficiently frequent treatment for their B12 deficiency?
What does
PAScomms
in
Pernicious Anaemia Society
5 months ago
Steroid inhalers and oral thrush.
Have recently started Relvar Ellipta inhaler and would like to know how to treat oral thrush? With many thanks. 🤗
Have recently started Relvar Ellipta inhaler and would like to know how to treat oral thrush? With many thanks. 🤗
Lupino
in
Lung Conditions Community Forum
5 months ago
Had results but still confused 🤷🏻♀️
After having biopsy samples taken during an incomplete colonoscopy back on 20th Jan and then having the CT pneumocolon on 8th Feb I have finally had the results read out to me by the med sec….not sure if it’s left me with more questions rather than answers 🤷🏻♀️ The biopsy results show inflammation
After having biopsy samples taken during an incomplete colonoscopy back on 20th Jan and then having the CT pneumocolon on 8th Feb I have finally had the results read out to me by the med sec….not sure if it’s left me with more questions rather than answers 🤷🏻♀️ The biopsy results show inflammation
PinkBubblez1
in
Colon Cancer Connected
5 months ago
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