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Out of Nivolumab/Opdivo Clinical Trial
My husband, Steve (Stevana on this site), is now out of the phase 2 clinical trial for the immunotherapy drug Nivolumab (a/k/a Opdivo). He started the trial in August, 2020 which also included infusions of Docetaxel. His last Docetaxel infusion was on December 3rd and he continued with infusions of Opdivo
My husband, Steve (Stevana on this site), is now out of the phase 2 clinical trial for the immunotherapy drug Nivolumab (a/k/a Opdivo). He started the trial in August, 2020 which also included infusions of Docetaxel. His last Docetaxel infusion was on December 3rd and he continued with infusions of Opdivo
Avanat
in
Advanced Prostate Cancer
3 years ago
Targeted therapy pralsetinib safely effectively treats lung and thyroid cancers with RET alterations
Results from the multi-cohort Phase I/II ARROW clinical trial, conducted by The University of Texas MD Anderson Cancer Center researchers, showed that a once-daily dose of pralsetinib, a highly selective RET inhibitor, was safe and effective in treating patients with advanced RET fusion-positive non-small
Results from the multi-cohort Phase I/II ARROW clinical trial, conducted by The University of Texas MD Anderson Cancer Center researchers, showed that a once-daily dose of pralsetinib, a highly selective RET inhibitor, was safe and effective in treating patients with advanced RET fusion-positive non-small
2greys
in
Lung Conditions Community Forum
3 years ago
'Could All the Experts Be Wrong About Parkinson's?'
"There is already more than enough dopamine inside the cells. In some ways, using dopaminergic therapies is akin to whipping a tired horse; it helps for a few strides but doesn't affect long-term results." "Four laboratory studies report that blocking production of dopamine within these brain cells improves
"There is already more than enough dopamine inside the cells. In some ways, using dopaminergic therapies is akin to whipping a tired horse; it helps for a few strides but doesn't affect long-term results." "Four laboratory studies report that blocking production of dopamine within these brain cells improves
PDConscience
in
Cure Parkinson's
3 years ago
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ASCO presentations on melanoma research this week
1. Iovance (advanced biotech company for use of Adoptive Cell Therapy/Tumor Infiltrating Lymphocytes (TIL) reports data at the 33 month follow up point. Early Intervention with Lifileucel Following Progression on Anti-PD-1 Therapy May Maximize Benefit. https://www.yahoo.com/now/iovance-biotherapeutics-announces
1. Iovance (advanced biotech company for use of Adoptive Cell Therapy/Tumor Infiltrating Lymphocytes (TIL) reports data at the 33 month follow up point. Early Intervention with Lifileucel Following Progression on Anti-PD-1 Therapy May Maximize Benefit. https://www.yahoo.com/now/iovance-biotherapeutics-announces
missyrand
Ambassador
in
Melanoma Caregivers
3 years ago
Japanese stem cell treatment for Parkinson's set for US trials
A Japanese drugmaker plans clinical trials in the U.S. of a regenerative treatment for Parkinson's disease that uses reprogrammed cells. https://asia.nikkei.com/Business/Pharmaceuticals/Japanese-stem-cell-treatment-for-Parkinson-s-set-for-US-trials
A Japanese drugmaker plans clinical trials in the U.S. of a regenerative treatment for Parkinson's disease that uses reprogrammed cells. https://asia.nikkei.com/Business/Pharmaceuticals/Japanese-stem-cell-treatment-for-Parkinson-s-set-for-US-trials
Farooqji
in
Cure Parkinson's
3 years ago
First results of a head-to-head trial of acalabrutinib versus ibrutinib in previously treated chronic lymphocytic leukemia.
Background: Increased selectivity of the Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (Aca) vs ibrutinib (Ib) may improve tolerability. We conducted an open-label, randomized, noninferiority, phase 3 trial to compare Aca vs Ib in patients (pts) with chronic lymphocytic leukemia (CLL). Methods
Background: Increased selectivity of the Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (Aca) vs ibrutinib (Ib) may improve tolerability. We conducted an open-label, randomized, noninferiority, phase 3 trial to compare Aca vs Ib in patients (pts) with chronic lymphocytic leukemia (CLL). Methods
Jm954
Administrator
in
CLL Support
3 years ago
Cancer 'power failure' stops the spread of tumor cells
Sirturo, targeted the fuel supply of cancer cells and blocked metastasis by nearly 85%. The drug had no effects on normal cells, thereby minimizing side-effects. It found that treatment with Sirturo caused a 'power failure," but only in cancer cells. Sirturo is already FDA-approved, with these findings
Sirturo, targeted the fuel supply of cancer cells and blocked metastasis by nearly 85%. The drug had no effects on normal cells, thereby minimizing side-effects. It found that treatment with Sirturo caused a 'power failure," but only in cancer cells. Sirturo is already FDA-approved, with these findings
Richard_TX
in
CLL Support
3 years ago
Finally joining in...
I'm not new here, but I have only been a spectator for a few years. I'm 71, diagnosed with prostate cancer 20 years ago. After radical prostatectomy, clinical trial of chemo, and external beam radiation, the psa slowly rose until about 4 years ago, when I began Lupron injections. The psa went down
I'm not new here, but I have only been a spectator for a few years. I'm 71, diagnosed with prostate cancer 20 years ago. After radical prostatectomy, clinical trial of chemo, and external beam radiation, the psa slowly rose until about 4 years ago, when I began Lupron injections. The psa went down
Okay4now
in
Advanced Prostate Cancer
3 years ago
University of Kentucky Phase 1 trial of CBD oil For PCa BCR. Estimated study completion time September 2021.
A phase I, dose-expansion cohort study on the safety of a cannabidiol for biochemical recurrence in prostate cancer patients. Zin Myint, William H. St Clair, Stephen Strup, Peng Wang, Andrew Callaway James, Donglin Yan, ... Abstract TPS263 Background: Cannabinoids, widely used in pain control, as an
A phase I, dose-expansion cohort study on the safety of a cannabidiol for biochemical recurrence in prostate cancer patients. Zin Myint, William H. St Clair, Stephen Strup, Peng Wang, Andrew Callaway James, Donglin Yan, ... Abstract TPS263 Background: Cannabinoids, widely used in pain control, as an
Graham49
in
Advanced Prostate Cancer
3 years ago
CLINICAL TRIALS RE MANITOL
Is anyone aware of any clinical trials involving manitol?
Is anyone aware of any clinical trials involving manitol?
SonarsMom
in
Cure Parkinson's
3 years ago
Newly approved drug effective against lung cancer caused by genetic mutation
The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial. The drug is designed to shut down the effects of the mutation, which is found in about 13% of patients
The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial. The drug is designed to shut down the effects of the mutation, which is found in about 13% of patients
2greys
in
Lung Conditions Community Forum
3 years ago
Positive Effects of HIIT Exercise program on BCR progression of PC
From the ASCO2021 programs. Good randomized trial of supervised intensive exercise for 12 weeks improves risks for BCR progression. I suspect this may be related to the effects of exercise, and especially HIIT to activate epigenetic pathways for protection of the genome and reducing mutations, a driver
From the ASCO2021 programs. Good randomized trial of supervised intensive exercise for 12 weeks improves risks for BCR progression. I suspect this may be related to the effects of exercise, and especially HIIT to activate epigenetic pathways for protection of the genome and reducing mutations, a driver
MateoBeach
in
Advanced Prostate Cancer
3 years ago
Inflammatory Pathophysiology as a Contributor to MPN
« Clinical evidence that JAK2 inhibition by ruxolitinib in MF neither reliably reduces malignant clonal burden nor eliminates cytokine elevations, suggests targeting cytokine mediated signaling as a therapeutic strategy, which is being pursued in new clinical trials » « The clearly prominent role of
« Clinical evidence that JAK2 inhibition by ruxolitinib in MF neither reliably reduces malignant clonal burden nor eliminates cytokine elevations, suggests targeting cytokine mediated signaling as a therapeutic strategy, which is being pursued in new clinical trials » « The clearly prominent role of
Manouche
in
MPN Voice
3 years ago
new-radiation-therapy
https://www.nbcnews.com/health/mens-health/new-radiation-therapy-prostate-cancer-reduces-deaths-study-shows-n1269566 that level of improvement. June 3, 2021, 5:21 PM EDT By Linda Carroll By the time Michael Rosenblum’s prostate cancer was discovered, it was already at a late stage. He’d initially
https://www.nbcnews.com/health/mens-health/new-radiation-therapy-prostate-cancer-reduces-deaths-study-shows-n1269566 that level of improvement. June 3, 2021, 5:21 PM EDT By Linda Carroll By the time Michael Rosenblum’s prostate cancer was discovered, it was already at a late stage. He’d initially
PeteLG
in
Advanced Prostate Cancer
3 years ago
I've written about 80 pages of a prostate cancer book. It is primarily focused on non-SOC, but govt researched methods.
This is my take on some drugs and supplements. I'm sure that there are others that I will add or delete as time goes on (I'm working my way through clinical trials, PubMed, examine, and some other sources). I've been following some of this from shortly after diagnosis. And all of it for a couple of months
This is my take on some drugs and supplements. I'm sure that there are others that I will add or delete as time goes on (I'm working my way through clinical trials, PubMed, examine, and some other sources). I've been following some of this from shortly after diagnosis. And all of it for a couple of months
Hidden
in
Advanced Prostate Cancer
3 years ago
Two new drug approvals (for patients with EGFR Exon 20 insertion and patients with KRAS G12C mutation)
Hi everyone, I know Denzie posted about at least one of the new drug approvals fbut I figured it can't hurt to post about the new approvals again so people are aware of them. With both approvals, I wanted to share why it's important to know what your biomarker test results. Sometimes healthcare professionals
Hi everyone, I know Denzie posted about at least one of the new drug approvals fbut I figured it can't hurt to post about the new approvals again so people are aware of them. With both approvals, I wanted to share why it's important to know what your biomarker test results. Sometimes healthcare professionals
Miranda_GO2
Partner
in
Lung Cancer Support
3 years ago
Leukemia & Lymphoma Society COVID-19 vaccine safety data is now available ; vaccine antibody data expected later in 2021
On behalf of the Leukemia & Lymphoma Society, thank you again for joining the LLS National Patient Registry, a project of the Michael J. Garil Patient Data Collective, and a special thanks to those of you who are participating in our COVID-19 study. This study is giving us unique information and insights
On behalf of the Leukemia & Lymphoma Society, thank you again for joining the LLS National Patient Registry, a project of the Michael J. Garil Patient Data Collective, and a special thanks to those of you who are participating in our COVID-19 study. This study is giving us unique information and insights
lankisterguy
Volunteer
in
CLL Support
3 years ago
Radical Prostatectomy vs External Beam Radiation Therapy for High-Grade, Clinically Localized Prostate Cancer
TAKE-HOME MESSAGE This retrospective study sought to emulate a randomized trial comparing outcomes between prostatectomy and radiation therapy for high-grade (Gleason score 8–10), clinically localized prostate cancer. The data were extracted from the National Cancer Database (2006–2015) and propensity
TAKE-HOME MESSAGE This retrospective study sought to emulate a randomized trial comparing outcomes between prostatectomy and radiation therapy for high-grade (Gleason score 8–10), clinically localized prostate cancer. The data were extracted from the National Cancer Database (2006–2015) and propensity
Balsam01
in
Advanced Prostate Cancer
3 years ago
OxPLoreD clinical trial for those with high count MBL or early stage CLL --More recruits needed
As Milla15 wrote 6 months ago "this trial which is currently recruiting for high count Monoclonal B-cell Lymphocytosis or very early stage CLL patients (as well as a couple of other early stage blood disorders of uncertain significance). Trial will last 5 years and aims to discover markers which can
As Milla15 wrote 6 months ago "this trial which is currently recruiting for high count Monoclonal B-cell Lymphocytosis or very early stage CLL patients (as well as a couple of other early stage blood disorders of uncertain significance). Trial will last 5 years and aims to discover markers which can
JEEA
in
CLL Support
3 years ago
Antibiotics no help for mysterious lung-scarring disease, large trial finds.
Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death. While there were no statistical benefits for patients with the lung-scarring
Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death. While there were no statistical benefits for patients with the lung-scarring
2greys
in
Lung Conditions Community Forum
3 years ago
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