Experiences with

Triple Sulfa

Hi Fellas I’m now almost 19 years since original dx and almost 11 years Stage 4. At the moment going through second chemo campaign, but there is disease progression. There is only one clinical trial I meet the criteria for which I hope to start in May after my last chemo. Lutetium 177 would probably

Hey folks I've been researching and meeting with different doctors to get their recommendations for treatment. I'm zeroing in on a plan, but I'd like to get some feedback from you all. I was diagnosed in 2017 and have been on AS since. Recent testing (MRI, Biopsy, PET/CT scan) shows 3+4 with about

Solaxa has announced plans to conduct a phase 3 clinical trial of their drug SLX-100 (repurposed 4-Aminopyridine) for Spinocerebellar ataxia 27B (SCA27B). The trial will be based in the US, but additional trial sites are to be announced later this year. Read more on our website. #AtaxiaResearch

TTX-MC138, an RNA-based therapeutic targeting microRNA-10b, implicated in metastatic cancers is currently in Phase 1 clinical trial. The trial has progressed to its fourth cohort, administering a dose approximately 50% higher than the previous cohort, with no significant safety issues or dose-limiting

Hi community, Back in December, we reached out to learn more about what you’d like to know regarding clinical trials. Thanks to your valuable input, we’ve created a collection of new educational resources designed to help you better understand the clinical trial process and how to evaluate potential

​A recent Phase I clinical trial has revealed that FOR46, an experimental antibody-drug conjugate targeting the CD46 protein, demonstrates promising efficacy in treating metastatic castration-resistant prostate cancer (mCRPC). Among patients treated at doses of 1.2 mg/kg or higher, the median radiographic

Hi all, This is my first post here. My 66 year old father was diagnosed with metastatic PCa in April 2024. Initial PSA was 35.6, Gleason 5+4. A month later, PSMA-PET showed widespread mets in the tissues surrounding his prostate, including bones and lymph nodes. He did [i]not[/i] have mets in his head

Others may have posted something similar, but for all of us with advanced prostate cancer it is such a mental roller coaster and it is exhausting. First I’ll I’m very thankful for the treatments that are out there and for all of the people/ warriors that have gone before us and done clinical trials

A new partnership in biotech is pushing the boundaries of personalized cancer treatment by developing AI-guided peptide vaccines tailored to each patient’s unique tumor profile. Using a powerful cloud-based platform, scientists can rapidly analyze tumor genetics and create custom vaccines that train

Hi Just want to update you on my journey on this clinical trial INCA 33989. I am now at my 4th infusions and my platelets are now 337. They became normal after one dose. I was at 775 of platelets at the start of the study. No side effects. Was on Pegasys for 15 years. I was diagnosed at 33 and now

Sigh... Comparative Analysis of MK-4541 and S-40542 1. MK-4541 Mechanism of Action Dual Activity: Acts as a selective androgen receptor modulator (SARM) and 5α-reductase inhibitor. AR Antagonist: Blocks androgen receptor (AR) signaling in prostate cancer cells. 5α-Reductase Inhibition:

Clinical trials in progress • Intermittent darolutamide trial: 1. Is There an Opportunity to De-Escalate Treatments in Selected Patients with Metastatic Hormone-Sensitive Prostate Cancer? – PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC11240449/ 2. Study Details | Intermittent Darolutamide Treatment

JH has a special assay. Not available to the public. Predicting Efficacy of Bipolar Androgen Therapy (BAT) in Prostate Cancer Key Predictive Biomarkers and Mechanisms Based on recent clinical trials and mechanistic studies, the following factors predict BAT efficacy: Biomarker/Mechanism Predictive

Strategies to Resensitize CRPC to AR-Targeted Therapies Castration-resistant prostate cancer (CRPC) often remains driven by the androgen receptor (AR) pathway despite resistance to standard AR-targeted treatments. Numerous strategies – from drugs and combinations to hormonal cycling and lifestyle changes

I'm testing this to verify but it appears that using Zytiga within 4-5 weeks of SPA is a big no-no. Zytiga's first metabolite is Δ4-Abiraterone. It inhibits 5-ar. So, inhibits T->DHT. Should be simple to test. I'll have the first half of the results this week. N of 1 but I'm the 1 so good on me :) If

The UK Kidney Ecosystem at the University of Liverpool is hosting an online event on April 4th (12 PM - 1 PM) for individuals with lived experience of IgA Vasculitis (Henoch-Schönlein Purpura). This event is a vital opportunity for those affected to share their insights and help shape a new clinical

Hello Everyone, I was previously on the PSMAdditions trial since January 2023 with 6th and final infusion in August 2023. My PSA was undetectable until several months ago. I had a PET scan in October that showed new lesion in my acetabulum. So I had external radiation to the area but it has spread

Has anyone heard of this...? And if so, what do you think about it? https://www.zgm.care/ Who Zhittya is: Zhittya Genesis Medicine is a Nevada (USA)-based biotechnology company, working to treat diseases which are responsible for the deaths of millions throughout the world. A lack of blood flow is

FMD is a 5 day severe diet. I do it once a month. Had personal issues in 2024. Ate SAD. Ballooned from 220 to 300+. Started eating right in October 2024. Got disciplined last month. Down to 235. If anyone is interested I designed a diet plan that seems to work. Love your comments Max. I designed the

With all of the medical research budget cuts happening , cancer research is most often mentioned as the biggest victim. Since all of us are hoping to stay alive until new treatments come online to extend our lives or cure the disease, I’m wondering if anybody has heard or experienced any specific examples