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Potential therapeutic effects and pharmacological evidence of sinomenine in central nervous system disorders
Published online 2022 Sep 16, I realize it is a rat study, but it is sinomenine is used in Traditional Chinese Medicine. Pharmacological effects of sinomenine in Parkinson’s disease PD is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the
Published online 2022 Sep 16, I realize it is a rat study, but it is sinomenine is used in Traditional Chinese Medicine. Pharmacological effects of sinomenine in Parkinson’s disease PD is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the
Sydney75
in
Cure Parkinson's
11 months ago
Non Medical Sleep aid
I found something that helps my sleep. According to my sleep tracker, I am setting new records in the quality of my sleep! What changed? I bought a sleep mask. It was less than $20... Amazon. I became addicted on day 1. It is amazing how something so simple could help so much. I know we
I found something that helps my sleep. According to my sleep tracker, I am setting new records in the quality of my sleep! What changed? I bought a sleep mask. It was less than $20... Amazon. I became addicted on day 1. It is amazing how something so simple could help so much. I know we
WideBody
in
Restless Legs Syndrome
2 years ago
Serum ferritin level & RBC count help please
Hi there, just wondered If anyone could please tell me if a Ferritin level of 44ng/ml and a RBC count of 3.76 (whilst actually already taking Ferrous Fumerate 210mg twice per day) is still pretty low and ‘could’ maybe be the reason I’m still feeling exhausted/heavy tired legs?? Thank you in advance
Hi there, just wondered If anyone could please tell me if a Ferritin level of 44ng/ml and a RBC count of 3.76 (whilst actually already taking Ferrous Fumerate 210mg twice per day) is still pretty low and ‘could’ maybe be the reason I’m still feeling exhausted/heavy tired legs?? Thank you in advance
CandiR
in
Pernicious Anaemia Society
11 months ago
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Losing track of where you are while driving
Have you ever lost track of where you are while driving? I've probably had this occur 3-4 times in the last year in places I have gone to many times. Twice this was when I was approaching a street where I had to turn. Suddenly I didn't know if I needed to keep going or turn, or had taken the wrong
Have you ever lost track of where you are while driving? I've probably had this occur 3-4 times in the last year in places I have gone to many times. Twice this was when I was approaching a street where I had to turn. Suddenly I didn't know if I needed to keep going or turn, or had taken the wrong
Doxy46
in
MPN Voice
11 months ago
Bolt's Failed Pickle Experiment (Lectins) :(
First off, for those who don't know me, I have NOT been diagnosed with PD
. I was diagnosed with REM Sleep Behavior Disorder back in April 21, which the experts say will lead to PD or something worse. When I was diagnosed I did have some other odd symptoms. Mild balance issues, Seborrheic dermatitis
First off, for those who don't know me, I have NOT been diagnosed with PD
. I was diagnosed with REM Sleep Behavior Disorder back in April 21, which the experts say will lead to PD or something worse. When I was diagnosed I did have some other odd symptoms. Mild balance issues, Seborrheic dermatitis
Bolt_Upright
in
Cure Parkinson's
11 months ago
Thin, fragile skin
I thought it might be helpful to post this for those of us with very thin, easily damaged skin. It’s one of the many hazards of long-term, high dose steroid use, including inhalers. Of course, if it weren’t for steroids I wouldn’t be here, so I’m glad they’re available. After decades of steroid use
I thought it might be helpful to post this for those of us with very thin, easily damaged skin. It’s one of the many hazards of long-term, high dose steroid use, including inhalers. Of course, if it weren’t for steroids I wouldn’t be here, so I’m glad they’re available. After decades of steroid use
janedivney
in
Asthma Community Forum
2 months ago
Legal Advice?
Hi All, Although this post is not MS-related, I wanted to reach out to my MSAA Community for their input. Perhaps someone here can point me in the right direction, as I don't really have the money to hire an attorney. Unfortunately, this situation doesn't lend itself to any "free advice and/or attorneys
Hi All, Although this post is not MS-related, I wanted to reach out to my MSAA Community for their input. Perhaps someone here can point me in the right direction, as I don't really have the money to hire an attorney. Unfortunately, this situation doesn't lend itself to any "free advice and/or attorneys
DM0329
in
My MSAA Community
11 months ago
I want to help if I can
I have be dx in1986 w/ RRMS, I had be misdiagnosed approximately 5 times, one of the Dr.s telling me to quit my job in a jail because I was a woman. Long story short I went completely paralyzed and in a rehab for approximately 6 weeks. I learned to walk, talk, adl, etc until my release when I went
I have be dx in1986 w/ RRMS, I had be misdiagnosed approximately 5 times, one of the Dr.s telling me to quit my job in a jail because I was a woman. Long story short I went completely paralyzed and in a rehab for approximately 6 weeks. I learned to walk, talk, adl, etc until my release when I went
BlondiePink
in
My MSAA Community
11 months ago
Epilepsy Action launches TV first aid campaign
https://www.epilepsy.org.uk/epilepsy-action-launches-tv-first-aid-campaign
https://www.epilepsy.org.uk/epilepsy-action-launches-tv-first-aid-campaign
EpilepsyAction1
Epilepsy Action
in
Epilepsy Action
3 months ago
Suboxone works!
As I stated in my first post, in May, 2023, I have had severe RLS for many years. I suffered augmentation after taking 4 mg Mirapex daily. In September, 2023, my sleep study doctor, at The University of Michigan, prescribed Suboxone. Also known as Buprenorphine and Naloxone 2 mg/0.5 mg. It is a sublingual
As I stated in my first post, in May, 2023, I have had severe RLS for many years. I suffered augmentation after taking 4 mg Mirapex daily. In September, 2023, my sleep study doctor, at The University of Michigan, prescribed Suboxone. Also known as Buprenorphine and Naloxone 2 mg/0.5 mg. It is a sublingual
Happygrandmother
in
Restless Legs Syndrome
6 months ago
Feel good post/Psychological first aid kit
What makes you feel better? Funny videos? Music? Videogames? Quotes? Thank you guys, you're helping me with my so complicated case
What makes you feel better? Funny videos? Music? Videogames? Quotes? Thank you guys, you're helping me with my so complicated case
Against_the_current
in
Anxiety and Depression Support
3 months ago
The Endotoxin Hypothesis of Parkinson's Disease
Abstract:
The endotoxin hypothesis of Parkinson's disease (PD) is the idea that lipopolysaccharide (LPS) endotoxins contribute to the pathogenesis of this disorder. LPS endotoxins are found in, and released from, the outer membrane of Gram-negative bacteria, for example in the gut. It is proposed
Abstract:
The endotoxin hypothesis of Parkinson's disease (PD) is the idea that lipopolysaccharide (LPS) endotoxins contribute to the pathogenesis of this disorder. LPS endotoxins are found in, and released from, the outer membrane of Gram-negative bacteria, for example in the gut. It is proposed
Bolt_Upright
in
Cure Parkinson's
11 months ago
Information
Hi all. I have had some bad attacks over the last several months when I’m in a crowded place and it’s noisy, so much so that I’ve had to leave the building. I think I know what causes it having completed a first aid course in 1976 but just wondering if this has happened to anyone else. It’s like a panic
Hi all. I have had some bad attacks over the last several months when I’m in a crowded place and it’s noisy, so much so that I’ve had to leave the building. I think I know what causes it having completed a first aid course in 1976 but just wondering if this has happened to anyone else. It’s like a panic
paul456
in
Ataxia UK
4 months ago
Pramipexole RLS symptoms worse
Just started taking Pramipexole for RLS for the first night. Wow, didn’t know the symptoms would become totally overwhelming all over body too.is this normal, does it settle down? I have Fibromyalgia, which means I also take Duloxetine for the pain and am medication sensitive, but never thought it would
Just started taking Pramipexole for RLS for the first night. Wow, didn’t know the symptoms would become totally overwhelming all over body too.is this normal, does it settle down? I have Fibromyalgia, which means I also take Duloxetine for the pain and am medication sensitive, but never thought it would
Fra3021
in
Restless Legs Syndrome
11 months ago
Sleep Aid
Anyone use children’s Benadryl or Unisom to help sleep? Or another remedy? My doctor actually suggested the children’s Benadryl but it was the first time I ever saw him, he is a family med doc and may not have been aware yet that I have controlled afib…
Anyone use children’s Benadryl or Unisom to help sleep? Or another remedy? My doctor actually suggested the children’s Benadryl but it was the first time I ever saw him, he is a family med doc and may not have been aware yet that I have controlled afib…
Jafib
in
Atrial Fibrillation Support
2 years ago
Sleep studies and RLS
Hello everyone. What have been your experiences of sleep studies, and how useful have they been in managing your RLS? Have they actually contributed at all to resolving your RLS symptoms? Or is their benefit just to make you aware of which sleep disorders you have and which you don’t? I ask because
Hello everyone. What have been your experiences of sleep studies, and how useful have they been in managing your RLS? Have they actually contributed at all to resolving your RLS symptoms? Or is their benefit just to make you aware of which sleep disorders you have and which you don’t? I ask because
restlegs1
in
Restless Legs Syndrome
11 months ago
Badminton Bolt 10K Race Report ⚡️😎👍
I had to do this one. It’s on my doorstep, the funds go to support a local school, the location is beautiful and it was my first 10K race since December 2021!!! Oh, and there was going to be bling 🤩 I didn’t find out until this morning that this was the very first Bolt 10K. There has been a 5K before
I had to do this one. It’s on my doorstep, the funds go to support a local school, the location is beautiful and it was my first 10K race since December 2021!!! Oh, and there was going to be bling 🤩 I didn’t find out until this morning that this was the very first Bolt 10K. There has been a 5K before
Irishprincess
Administrator
in
Fun Beyond 10K & Race Support
5 months ago
B12 made symptoms go away
Hi. I had ME/CFS and it seemed to clear up 16 years later. About 3 years ago, I had fatigue, myclonic jerks especially while sleeping which woke me up and tremor feeling inside me. I took B12 sublingual for 2 or 3 weeks and the symptoms subsided. But then I stopped taking the B12 supplements and I have
Hi. I had ME/CFS and it seemed to clear up 16 years later. About 3 years ago, I had fatigue, myclonic jerks especially while sleeping which woke me up and tremor feeling inside me. I took B12 sublingual for 2 or 3 weeks and the symptoms subsided. But then I stopped taking the B12 supplements and I have
MEguy
in
Pernicious Anaemia Society
1 year ago
Relaxium Sleep Aid
Wondering if anyone on here has experience with the Relaxium
Sleep
Aid
? Thanks #
sleep
aid
#insomnia
Wondering if anyone on here has experience with the Relaxium
Sleep
Aid
? Thanks #
sleep
aid
#insomnia
Jafib
in
Atrial Fibrillation Support
2 years ago
Red Light Therapy
I have been using Wellreds Coronet for two years. I sleep extremely well since I started using it ( I had terrible sleep problems for years ). Worth every penny ! I use their preset program 2 x/day
I have been using Wellreds Coronet for two years. I sleep extremely well since I started using it ( I had terrible sleep problems for years ). Worth every penny ! I use their preset program 2 x/day
Defiance
in
Cure Parkinson's
1 year ago
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