Just started taking Pramipexole for RLS for the first night. Wow, didn’t know the symptoms would become totally overwhelming all over body too.is this normal, does it settle down?
I have Fibromyalgia, which means I also take Duloxetine for the pain and am medication sensitive, but never thought it would be so bad.
Duloxitine is regarded as safe for RLS.
Pramipexole is outstandingly effective in stopping RLS in its tracks. However ,it is not good for long term usage due to a number of reasons,that I'm sure your doctor would have explained to you at length.
So I'm not sure what's going on with you.!!!
What other medications are you taking in your life?
You must be confusing it with something else as duloxetine makes RLS worse for most people.
There seems to be a difference in reactions. RLS is quoted at less than 5%
Insomnia is a more frequent reaction.
According to these researches.
🥵😭
Can duloxetine cause restless sleep?
Not being able to sleep (also called insomnia) is one of the most common side effects reported by people taking Cymbalta. In some people, this side effect improves after a couple of weeks of taking Cymbalta, but difficulty falling asleep or staying asleep can persist in others.19 Jan 2022
People also ask
Is restless legs a side effect of duloxetine?
11 In the open label trial, the frequency of drug-induced RLS symptoms with both venlafaxine and duloxetine was found less than 5%.5 May 2021
jpmrs.org › uplo...PDF
Duloxetine-induced Restless Legs Syndrome in a Patient with ...
My RLS was completely controlled by gabapentin. I can even take two Benadryl or melatonin without any RLS but when my doctor prescribed Cymbalta I(duloxetine) my RLS went through the roof. I saw a study which I don't have right now at 9%. In any case I wouldn't call it safe for RLS. See his post 5 days ago for others who say the same thing healthunlocked.com/rlsuk/po...
Your link isn't right as it has nothing to do with duloxetine.
Cymbalta is available as a generic drug called duloxetine. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug.
Yep. That's why I put it in parenthesis - Cymbalta (duloxetine). I do this frequently when I mention medicines and I don't bother with which one is the brand and which is the generic for which one to list first as I don't have them listed as such in my notes.
Pramiplexol is horrific and shouldn't be given to anyone due to augmentation..it'll work until it crucifies the person and the withdrawal, even worse !!!!
I made that very clear in my reply.
However, perspective is required in looking at how Pramipexol is used.
It is extremely effective in stopping RLS in its tracks , and may be used as a diagnostic tool.
Many people come on here saying they have RLS, but that dopamine agonists don't have any effect-----. I would say that they simply don't have RLS.
As I said in my answer, any doctor should explain clearly to a patient, the severe downsides of using DAs for long term.
Such as possibility of Augmentation, and increased addictive behaviour.
Perspective in all things.
Sorry your message reads ...outstandingly effective ....it shouldn't be used at all ....as will only result in awful withdrawal symptoms, this is not perspective this is fact .
I disagree with that view..
It does have a place in medical practice.
Many people have used Pramipexol for over 10 years without experiencing augmentation or addictive behaviour.
I also can understand why people distrust Pramipexol.. But babies and bathwater come to mind.🤔
Baz, the 5htp may be making the RLS worse. Has your RLS settled?
I take positive outlook which has combination 5htp and others and I take saffron....no interaction I researched it along with the herbalist. I went back on 2 x 325mg fumarate and 1800mg gabapentin spread out evenly through the day.
My ferritin dropped massively when I just took the bisglycinate so things have settled again..I've a home test ferritin kit so going to check later to see if the iron infusion has made a difference.....
Yay! Your RLS is under control and no more kicking. That’s what counts, whatever it takes.
i will say that pramipexole was a god send 11 yrs ago best thing that ever happened to me.. but am i suffering now i am trying to stop taking them i just cant my RLS are the worst they have ever been every night i mean it never a free night and sometimes in the day sometimes not my legs but my arms and in my side and tummy you honestly wouldnt believe your stomach could jump but i have no control i just have to sit up all nite 😒😢😒i wished i had never taken them xx
That is what the doctor should be warning you about.
At first sign of DA not working, -get off it.
You don't want to take Pramipexole. It is a dopamine agonist like ropinirole and up to 70% of people on it will suffer from augmentation which believe me you don't want because it can be hell to come off of it.
Why were you prescribed it? You said your RLS was under control with pregabalin.
Fra, try this drug (with doctor’s blessing of course) along with mild exercise. drugs.com/comments/trazodon....
These two things are allegedly a winning combo for Fibro. Please also try one night 50mg of ferrous bisglycinate, on an empty stomach, about an hour before bed, provided you don’t have an iron overload disorder. It should relieve your RLS in one hour, for one night. If it works, then please consult with your doctor before continuing. Even if it doesn’t work, talk to your doctor about an oral iron regimen to raise ferritin, on the outside chance that will help.
Well i might get blasted but on the RLS-UK website it has that antidepressant as can make RLS worse in a list of meds that can make RLS worse.
Pramiplexol has awful augmentation effects, I had to take myself off this and went through awful withdrawal symptoms. Gabapentin or pregabalin will not cause augmentation.
Please go back to your gp as this will only intensify .
want to share something that’s worked for me (Rls) Magnesium Glycenate- I take 2 or 3 at night.
There’s other types of Magnesium but the body apparently absorbs this one best.
Hope it helps someone 🙏
I take this .x
How is it working for you?
Slash, would you mind going through your entire RLS life story for us? Magnesium has become a VERY important topic-to me at least.
Of course. I first got RLS 5 years ago after I became anemic due to Ulcerative colitis (bleeding on the toilet). The second time was due to coming off the heroin substitute Methadone. It was a kick in the teeth to get it after all the hard work I’d done just as I was ready to get on with my life. During my first episode I was tried on the usual meds to no avail. All that was left was pregabs. I wasn’t happy about trying them because I didn’t want to be reliant on anything especially now I was clean. The side effects were horrendous so I ditched them after 3 weeks. The doctor then informed me we had ran out of options. By this point I was awake 5 days in a row and feeling desperate for relief. In the end I had to go back on methadone on a really low dose. Apparently opiates block a receptor in your brain that releases hormones to stop RLS. The receptor can take time to work properly and there’s no time limit. I’d been trawling the internet for advice and tips and came across Magnesium Glycenate. I started using it without RLS and started tapering the methadone very slowly. Thankfully when I made the leap to zero, RLS didn’t return.
Thank you for the great info. You seem pre-disposed to RLS, but we know that withdrawal from substances like methadone and tramadol can cause RLS for first time. ncbi.nlm.nih.gov/pmc/articl...
So this man eventually got relief via Ropinirole and then after a few weeks stopped the DA without return of the RLS. I used to believe that the opioids just caused a down-regulation of the dopamine receptors and that’s why people got RLS upon discontinuance and sometimes during use. I no longer think this is the case, exactly. I think instead that the tramadol or methadone causes a fairly dramatic increase in prolactin. pubmed.ncbi.nlm.nih.gov/645....
While a person is on methadone or tramadol, the increase in prolactin is offset by the dopamine agonist properties of the substance, or some other mechanism. Once it’s stopped, there’s this heightened prolactin level that is unopposed by enough dopamine. See this too: pubmed.ncbi.nlm.nih.gov/297...
Increased prolactin, and a cascade of events therefrom, as seen in pregnancy “may” trigger RLS. Prolactin levels are lowered by dopamine (that’s why the DA worked so well in that case study) and large (not small) amounts of magnesium will lower prolactin as well - as possibly in your case.
classic.clinicaltrials.gov/...
Since I put these puzzle pieces together myself, in an effort to prove my hypothesis, it could easily be completely wrong. 😳
Just wanted to add my experience with duloxetine (Cymbalta). After a week or so of use I had extreme RLS that was truly debilitating; worst ever in my life.
I’m sorry to hear the effects Prami had on you. I’ve noticed the same thing off and on. Was taking three a day and cut back to one a day and for the most part calms things down. Two night she was the total opposite. I’ve been on this drug for almost a year for my nureopathy. Weird disease to say them least.
Prami is no longer a first line treatment for RLS - see the Mayo Clinic Algorithm... healthunlocked.com/redirect...
Pramipexole symptoms 
Pramipexole 0.250mg as %100 RLS symptoms fix 
Severe RLS Augmentation on Pramipexole 
RLS, Pramipexole, Augmentation, HELP
RLS, Pramipexole & Vine Extract
