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More studies showing that SGLT2 inhibitors might be a useful prodrug for PCa
MateoBeach posted on SGLT2 inhibitors a year ago. Now three more studies show promise for prostate cancer. Note that the last study is a preprint. Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: A drug-target Mendelian randomization study Y Lin,
MateoBeach posted on SGLT2 inhibitors a year ago. Now three more studies show promise for prostate cancer. Note that the last study is a preprint. Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: A drug-target Mendelian randomization study Y Lin,
Graham49
in
Fight Prostate Cancer
9 days ago
Well wishes
Hi everyone, Thinking of everyone in this forum. I wanted to reach out and ask for some well wishes. My dad has been on Olaparib (lynparza) for the BRCA2 gene since October of 2023. His previous scans have been NED (last PET scan end of May). He is having a scan on Wednesday and I am feeling nervous
Hi everyone, Thinking of everyone in this forum. I wanted to reach out and ask for some well wishes. My dad has been on Olaparib (lynparza) for the BRCA2 gene since October of 2023. His previous scans have been NED (last PET scan end of May). He is having a scan on Wednesday and I am feeling nervous
Jenniferp2122
in
SHARE Metastatic Breast Cancer
9 days ago
Trail???
I am offered simultaneous Taxotere and XMAb20717-04 due to progressive PSA doubling time in <8 weeks from 2 to 4+ This trial is sponsored by Xencor. I would appreciate any information. My recent PMSA-PET showed new tumors and progression.
I am offered simultaneous Taxotere and XMAb20717-04 due to progressive PSA doubling time in <8 weeks from 2 to 4+ This trial is sponsored by Xencor. I would appreciate any information. My recent PMSA-PET showed new tumors and progression.
katartizo61
in
Advanced Prostate Cancer
10 days ago
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Diagnosed today with small cell Mets in liver
I was diagnised 18 months ago with PSA of 125 and 2-3 Mets to bone. None elsewhere. Dana Farber in Boston put me on Relogolix and Darolutemide and brought my PSA down to .02 over 4-5 months , which was described as Super Responder. Had a PSMA PET SCAN, which showed nothing on the prostate and only one
I was diagnised 18 months ago with PSA of 125 and 2-3 Mets to bone. None elsewhere. Dana Farber in Boston put me on Relogolix and Darolutemide and brought my PSA down to .02 over 4-5 months , which was described as Super Responder. Had a PSMA PET SCAN, which showed nothing on the prostate and only one
Cape1
in
Advanced Prostate Cancer
10 days ago
Immunotherapy Treatment
Is Immunotherapy only used for Advanced Prostate Cancer OR Is it being used for say Gleason 4+3= 7 cancer . And is it used alone or in combination with hormone and chemo. etc ?
Is Immunotherapy only used for Advanced Prostate Cancer OR Is it being used for say Gleason 4+3= 7 cancer . And is it used alone or in combination with hormone and chemo. etc ?
Conlig1940
in
Advanced Prostate Cancer
11 days ago
Good news - alendronic acid
Hi, I thought I would share some good news. Three years ago I was diagnosed with osteoporosis and started on alendronic acid with dome reluctance. After a rough first couple of weeks I got used to the medication. I modified my diet a bit, stsrting tsking Vit D and calcium, increased my BMI from 18.2
Hi, I thought I would share some good news. Three years ago I was diagnosed with osteoporosis and started on alendronic acid with dome reluctance. After a rough first couple of weeks I got used to the medication. I modified my diet a bit, stsrting tsking Vit D and calcium, increased my BMI from 18.2
Amber53
in
Bone Health and Osteoporosis UK
6 months ago
Dad's diagnosis
Hi everyone, not really sure what I'm after with this post, but just feel a bit lost. My dad has been diagnosed with prostate cancer. I live far away so haven't been able to attend appointments sadly and my parents are both bad at asking questions, so I don't have all the relevant information. We're
Hi everyone, not really sure what I'm after with this post, but just feel a bit lost. My dad has been diagnosed with prostate cancer. I live far away so haven't been able to attend appointments sadly and my parents are both bad at asking questions, so I don't have all the relevant information. We're
StaceyMac
in
Advanced Prostate Cancer
12 days ago
Gp wont prescribe
Hello. Im complety lost and ignored.About 2 yeara ago i finally gor my endo and adenomiosis diagnosis . I waa offered mirena and or hysteroctomy but both solutions arent what i wanted and instead I have been doing researches ever since. Once when I could not take it anymore, i went to rhe Gp to ask for
Hello. Im complety lost and ignored.About 2 yeara ago i finally gor my endo and adenomiosis diagnosis . I waa offered mirena and or hysteroctomy but both solutions arent what i wanted and instead I have been doing researches ever since. Once when I could not take it anymore, i went to rhe Gp to ask for
Marunheard
in
Endometriosis UK
12 days ago
Salvage treatment for radiorecurrent PCa
If I’m lucky I’ll soon be facing a decision as to which salvage treatment to have for radiorecurreent PCa. By lucky I mean that if upcoming tests show no spread outside of the prostate and I’m a candidate for salvage treatment. The salvage treatments I’m considering are SBRT, Brachytherapy and Cryotherapy
If I’m lucky I’ll soon be facing a decision as to which salvage treatment to have for radiorecurreent PCa. By lucky I mean that if upcoming tests show no spread outside of the prostate and I’m a candidate for salvage treatment. The salvage treatments I’m considering are SBRT, Brachytherapy and Cryotherapy
hwrjr
in
Advanced Prostate Cancer
12 days ago
Any suggestions for how to improve my poos
Hello all. My apologies for the title of this post, but I didn’t know how to phrase it. I was diagnosed with GCA in January 2023 and have been on Prednisone ever since, along with other meds that are given to mitigate the side effects of the Pred. I also started Methotrexate this January. My first attempt
Hello all. My apologies for the title of this post, but I didn’t know how to phrase it. I was diagnosed with GCA in January 2023 and have been on Prednisone ever since, along with other meds that are given to mitigate the side effects of the Pred. I also started Methotrexate this January. My first attempt
Handloomweaver
in
PMRGCAuk
6 months ago
It’s come back…feeling like rubbish
After being on Olaparib for 2 years it’s back. I have had very low CA125 and a clear scan in June. Last week bloods went crazy and was asked in for a scan. Today they’ve told me there is evidence of disease. They think they might be able to do surgery and then chemo again. They’ve said now that it’ll
After being on Olaparib for 2 years it’s back. I have had very low CA125 and a clear scan in June. Last week bloods went crazy and was asked in for a scan. Today they’ve told me there is evidence of disease. They think they might be able to do surgery and then chemo again. They’ve said now that it’ll
KelOC38
in
My Ovacome
13 days ago
It’s come back…feeling like rubbish
After being on Olaparib for 2 years it’s back. I have had very low CA125 and a clear scan in June. Last week bloods went crazy and was asked in for a scan. Today they’ve told me there is evidence of disease. They think they might be able to do surgery and then chemo again. They’ve said now that it’ll
After being on Olaparib for 2 years it’s back. I have had very low CA125 and a clear scan in June. Last week bloods went crazy and was asked in for a scan. Today they’ve told me there is evidence of disease. They think they might be able to do surgery and then chemo again. They’ve said now that it’ll
KelOC38
in
My Ovacome
13 days ago
Radiation Dosage
My husband is going tomorrow for simulation for radiation for IGMRT. We were informed by the nurse that the dosage would be 225 cGY fraction each for the 25 sessions for a total of 5625cGy. Sounds like a lot? Concerned about the side effects and what to expect. Reading other people’s dosages they seem
My husband is going tomorrow for simulation for radiation for IGMRT. We were informed by the nurse that the dosage would be 225 cGY fraction each for the 25 sessions for a total of 5625cGy. Sounds like a lot? Concerned about the side effects and what to expect. Reading other people’s dosages they seem
SherryKahn
in
Advanced Prostate Cancer
13 days ago
Just met my MO - was surprised he was a presenter at ESMO
Just met my MO. I was surprised to know he had attended ESMO and had presented something , though on breast cancer. Regarding dad’s results , he was happy with the fall In psa and ADT but said he was not comfortable that the T had risen from 26 to 41 in 2 months. Has said to do a repeat T
Just met my MO. I was surprised to know he had attended ESMO and had presented something , though on breast cancer. Regarding dad’s results , he was happy with the fall In psa and ADT but said he was not comfortable that the T had risen from 26 to 41 in 2 months. Has said to do a repeat T
Tinkudi
in
Advanced Prostate Cancer
13 days ago
Ivor Lewis operation on oesophagus is
I was diagnosed with a tumour in my oesophagus. Had chemo followed by surgery to have oesophagus removed and then more chemo . Last infusion was some two months ago . My problem now is that I am suffering from what feels like trapped air in my throat . I try to belch but it does not clear. After food
I was diagnosed with a tumour in my oesophagus. Had chemo followed by surgery to have oesophagus removed and then more chemo . Last infusion was some two months ago . My problem now is that I am suffering from what feels like trapped air in my throat . I try to belch but it does not clear. After food
Papanang
in
Oesophageal & Gastric Cancer
13 days ago
Relieved!
just had CT scan to access pain and discomfort. All good! Also, lymph nodes decreased in size about 50%. My doctor attributes the pain to Zanubrutinib side effect. Hopefully it will only be temporary. Looks like treatment is working! Thanks for all the input!
just had CT scan to access pain and discomfort. All good! Also, lymph nodes decreased in size about 50%. My doctor attributes the pain to Zanubrutinib side effect. Hopefully it will only be temporary. Looks like treatment is working! Thanks for all the input!
Nana1961
in
CLL Support
15 days ago
Residual tumour regrowth
Hi there, I had surgery in 2021 to remove a large AN. My follow-up MRI scans showed that all was well--until the last one, which shows regrowth. It's slight (from 17 x 5 mm to 22 x 7 mm) but it still really scares me. My consultation with my neurosurgeon (the one who saved me before) isn't until the
Hi there, I had surgery in 2021 to remove a large AN. My follow-up MRI scans showed that all was well--until the last one, which shows regrowth. It's slight (from 17 x 5 mm to 22 x 7 mm) but it still really scares me. My consultation with my neurosurgeon (the one who saved me before) isn't until the
sunshineandfrost
in
Acoustic Neuroma Support
15 days ago
Immunotherapy before/after or concurrent with Chemotherapy
Hii all , My father is failing ADT and next step is to start chemotherapy . I have discussed the case with APAC Biotech Gurugram regarding Immunotherapy . They have suggested to do it before chemotherapy as the tumor cells will shrink during chemo treatment and they will not be able to get good quality
Hii all , My father is failing ADT and next step is to start chemotherapy . I have discussed the case with APAC Biotech Gurugram regarding Immunotherapy . They have suggested to do it before chemotherapy as the tumor cells will shrink during chemo treatment and they will not be able to get good quality
jeetu_g27
in
Advanced Prostate Cancer
15 days ago
Need Help NOW
Hello fellow fighters! My husband has recently finished 6 rounds of Pluvicto and his PSMA PET scan has shown considerable spread throughout his bones. His PSA continued to rise during the Pluvicto treatment and the RO convinced us that it was probably just debris field from the dying bone lesions. It
Hello fellow fighters! My husband has recently finished 6 rounds of Pluvicto and his PSMA PET scan has shown considerable spread throughout his bones. His PSA continued to rise during the Pluvicto treatment and the RO convinced us that it was probably just debris field from the dying bone lesions. It
Fighting4u
in
Advanced Prostate Cancer
16 days ago
ESMO 2024: Opevesostat (MK-5684/ODM-208) in metastatic CRPC updated CYPIDES phase 2 results
Not bad but you need a mutation! The trial enrolled 134 heavily pre-treated mCRPC patients who had progressed after at least one novel hormonal agent and one taxane chemotherapy. Among these patients, 66 had activating mutations in the androgen receptor ligand-binding domain (AR-LBD), known to confer
Not bad but you need a mutation! The trial enrolled 134 heavily pre-treated mCRPC patients who had progressed after at least one novel hormonal agent and one taxane chemotherapy. Among these patients, 66 had activating mutations in the androgen receptor ligand-binding domain (AR-LBD), known to confer
Maxone73
in
Advanced Prostate Cancer
16 days ago
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