Trail???

[katartizo61]

I am offered simultaneous Taxotere and XMAb20717-04 due to progressive PSA doubling time in <8 weeks from 2 to 4+ This trial is sponsored by Xencor.

I would appreciate any information.

My recent PMSA-PET showed new tumors and progression.

[Maxone73]

data from phase 1 study where they have used it as monotherapy are encouraging, you will try the combined therapy. If you are taxane naive it could really give you good results. There are no preliminary results about the phase 2 trial at the moment but it looks promising.

[katartizo61 in reply to Maxone73]

Thank you. If effective the immune part can be preformed every 2 weeks for 2 years. Interesting choices. This would be my first chemo treatment,

[Tall_Allen]

Here's the small Phase 1 trial:

"The CRPC responders (2/7 with RECIST-measurable disease) had confirmed PSA decreases ≥ 50% from baseline (to 0.02 and 0.3 ng/mL); neither had progression on bone scans."

jitc.bmj.com/content/9/Supp...

So, if you are lucky, as 28% were, it might be helpful.

Here's more details on the trial:

clinicaltrials.gov/study/NC...

It depends on deactivating immune checkpoint inhibitors, PDL-1 and CTLA-4. Other drugs that do that, like Keytruda and Yervoy, are not very active in prostate cancer. Prostate cancer tends to be "immune cold." Many patients who are candidates for that trial also have a CDK12 mutation. If you do, also consider these trials:

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

classic.clinicaltrials.gov/...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

[katartizo61 in reply to Tall_Allen]

Thank you so very much Tall Allen. My COLOR genetic testing came back with no cancer related mutations. My MO pointed to some unrelated mutation. I am curious as to what sets off the "disease progression" My guess I'm not alone.

[Tall_Allen in reply to katartizo61]

I didn't have any germline mutations on COLOR either. Most men don't.

It's a good idea for you to get a tumor biopsy of a recent metastasis.

If you look at the biochemical operations that have to go right for perfect genomic replication, and how inexact the enzymes are, it is a miracle that more people don't get cancer.

[katartizo61 in reply to Tall_Allen]

I like the new tumor biopsy plan, could that change the chemo cocktail?

[katartizo61 in reply to katartizo61]

I have the option of only chemo, my first course and maybe adding something later. I have a bit of unease about trials. Your thoughts? Thank you

[Tall_Allen in reply to katartizo61]

Patients enrolled in trials are watched very closely and get the best care.

[Tall_Allen in reply to katartizo61]

Probably not. It might change the trials that are suitable for you.

[katartizo61 in reply to Tall_Allen]

Thank you

[KocoPr]

you might want to read this as it will take no effort to implement.

Checkpoint inhibitor responses can be regulated by the gut microbiota – A systematic review

ncbi.nlm.nih.gov/pmc/articl...

[katartizo61 in reply to KocoPr]

big believer, thank you

[1031Cancer]

My husband just started the phase 2 clinical trial with this drug along with Carboplatin and Cabazitaxel. Today he has all three infusions, with the clinical drug administered every two weeks. Hoping for some positive outcome.

Good luck to you. I'd love to compare notes if you move forward.

[katartizo61 in reply to 1031Cancer]

wow, you decided to go with the entire package. What was your deciding factor between only chemo and adding the study? Where do you live? Me Pittsburgh

[cancervictim]

do you know the name of your trial or any other identifying information? Thanks.

[katartizo61 in reply to cancervictim]

XmAb20717 vudalimab by Xencor that's all I see