Diagnosed today with small cell Mets in liver

[Cape1]

I was diagnised 18 months ago with PSA of 125 and 2-3 Mets to bone. None elsewhere. Dana Farber in Boston put me on Relogolix and Darolutemide and brought my PSA down to .02 over 4-5 months , which was described as Super Responder. Had a PSMA PET SCAN, which showed nothing on the prostate and only one remaining met in a leg bone. Life was good. Stayed on both drugs for total of ten months and was granted a holiday, which lasted about 4.5 month, during which my testosterone came back up to about 500 and my PSA to 18.

Got scans and tests in May and liver was good. Went back on Relogolix and Darolutemide, and PSA and testosterone again dropped rapidly. I was at .125 a week ago, and presumably headed back to undetectable

however, I recently began having pain under right ribs and MRI showed liver lesions, although liver panel remains good. Had liver biopsy on Friday and got the call just now. Small cell. Doctor said very unusual to go bad from where I was, but shit happens.

I will begin three days of chemo with an immunological component on Wednesday Total of six such sessions over 18 weeks

I’m 69, and otherwise in very good health, because of plant based diet, weight room, and HIIT swimming

Would welcome any constructive suggestions as I continue to fight the beast

[6357axbz]

Did you ever have your prostate removed or radiated?

[Cape1 in reply to 6357axbz]

No.

Neither

[Tall_Allen]

At Dana Farber, you have the world expert in Small cell prostate cancer, Misha Beltran. I suggest you get a second opinion from her.

They are probably starting you on a chemo cocktail with carboplatin.

Here are some clinical trials:

prostatecancer.news/2016/12...

[Cape1]

this is from todays conversation with Farber Doctor, describing what they want to do, in addition to a brain scan.

>> so that the therapies that I would give you are carboplatin, OK, another one is called etoposide, and then the immunotherapy component is called atezolibumab

Jeff: are those the Platinum based?

:so the carboplatin is a platinum based chemotherapy okay and the etoposide is a different type of chemotherapy and then these atezolibumab is an immunotherapy

[dhccpa in reply to Cape1]

If you intended TA to see this, you might want to reply directly (on this chain, not privately) to his earlier answer. He often doesn't read comments to posts beyond the initial post and your direct replies to his initial comments on it.

Great question, by the way.

[Parscore]

Maybe look at a newer treatment called, Histotripsy. for the liver. They do offer it at Swedish in Seattle, but I think the wait time is long.