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CRISPR: promising in vitro but I can barely understand it!
In Vitro Prostate Cancer Treatment via CRISPR-Cas9 Gene Editing Facilitated by Polyethyleneimine-Derived Graphene Quantum Dots. https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/148829-in-vitro-prostate-cancer-treatment-via-crispr-cas9-gene-editing-facilitated-by-polyethyleneimine-derived-graphene-quantum-dots.html
In Vitro Prostate Cancer Treatment via CRISPR-Cas9 Gene Editing Facilitated by Polyethyleneimine-Derived Graphene Quantum Dots. https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/148829-in-vitro-prostate-cancer-treatment-via-crispr-cas9-gene-editing-facilitated-by-polyethyleneimine-derived-graphene-quantum-dots.html
Maxone73
in
Advanced Prostate Cancer
5 months ago
Lymph node Metastasis
After 7 years, and multiple PSMA scans, my husband had a FDG CT scan and it showed what they quoted as “several” metastasis In the lymphs In the para aortic area in abdomen. One doc wants to biopsy to check if cancer DNA has changed from original pathology in 2017. Another doc says… No to biopsy due
After 7 years, and multiple PSMA scans, my husband had a FDG CT scan and it showed what they quoted as “several” metastasis In the lymphs In the para aortic area in abdomen. One doc wants to biopsy to check if cancer DNA has changed from original pathology in 2017. Another doc says… No to biopsy due
JolleySprings
in
Advanced Prostate Cancer
2 months ago
What’s after Lu-177 in Vancouver, BC?
Hi there, I’m located in Vancouver, BC 🇨🇦. My dad is on a clinical trial and after over a decade with this disease he has failed Zytiga, Xtandi, docetaxel, and is now on his 4/6 Lu-177 infusion. He’s castration-resistant and metastatic. PSA decreased considerably after the first Lu-177 infusion but
Hi there, I’m located in Vancouver, BC 🇨🇦. My dad is on a clinical trial and after over a decade with this disease he has failed Zytiga, Xtandi, docetaxel, and is now on his 4/6 Lu-177 infusion. He’s castration-resistant and metastatic. PSA decreased considerably after the first Lu-177 infusion but
PHnerd
in
Advanced Prostate Cancer
5 months ago
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Spinal uptake
Afternoon fellow warriors, after a recent Pet scan they have found 2 spots one on my upper spine and the other on my neck.My Oncologist is worried having radiotherapy on my neck maybe to close to the spinal cord should I be worried that this is the case. She is suggesting I just move into a different
Afternoon fellow warriors, after a recent Pet scan they have found 2 spots one on my upper spine and the other on my neck.My Oncologist is worried having radiotherapy on my neck maybe to close to the spinal cord should I be worried that this is the case. She is suggesting I just move into a different
Chubby42
in
Advanced Prostate Cancer
2 months ago
Does ADT work for Gleason 9?
About to start ADT for Gleason 9 (5+4) for locally advanced prostate cancer, followed by IMRT in 1-2 months. (Plan to ask about HDR boost). PSMA Pet negative for spread but MO had another radiologist look at initial prostate MRI suggests extracapsular extension along neurovascular bundle with possible
About to start ADT for Gleason 9 (5+4) for locally advanced prostate cancer, followed by IMRT in 1-2 months. (Plan to ask about HDR boost). PSMA Pet negative for spread but MO had another radiologist look at initial prostate MRI suggests extracapsular extension along neurovascular bundle with possible
Hope49823
in
Advanced Prostate Cancer
5 months ago
Carnosine as potential initial PCa treatment
Researchers have discovered that a naturally-occurring molecule could potentially be an effective first line of treatment against prostate cancer. Nottingham Trent University (NTU) scientists investigated the anti-cancer properties of carnosine, which can be produced in the body and is also found
Researchers have discovered that a naturally-occurring molecule could potentially be an effective first line of treatment against prostate cancer. Nottingham Trent University (NTU) scientists investigated the anti-cancer properties of carnosine, which can be produced in the body and is also found
Derf4223
in
Advanced Prostate Cancer
5 months ago
Rising PSA 1 year after RALP
I've been getting ultra sensitive PSA tests every three months. These are the last three scores: 0.015 0.017 0.026 (First PSA test after surgery was <0.1) I am worried. Frightened, actually. Margins were not clear on my surgical biopsy, though gleason was only 3+3. Two biopsies prior
I've been getting ultra sensitive PSA tests every three months. These are the last three scores: 0.015 0.017 0.026 (First PSA test after surgery was <0.1) I am worried. Frightened, actually. Margins were not clear on my surgical biopsy, though gleason was only 3+3. Two biopsies prior
SmasherOfAjumma
in
Prostate Cancer Network
5 months ago
Seeking anyone familiar with aggressive small cell neuroendocrine prostate cancer and/or with lurbinectedin as 2nd line chemotherapy.
A needle biopsy Oct 15, 2023 revealed that at least some of my metastatic prostate cancer in a lymph node had mutated to an aggressive small cell neuroendocrine prostate cancer. (notable for CDK N1B, RB1, Tp53 mutations. MSS, TMB low) I had 4 cycles of carboplatin/etoposide chemotherapy, which ended
A needle biopsy Oct 15, 2023 revealed that at least some of my metastatic prostate cancer in a lymph node had mutated to an aggressive small cell neuroendocrine prostate cancer. (notable for CDK N1B, RB1, Tp53 mutations. MSS, TMB low) I had 4 cycles of carboplatin/etoposide chemotherapy, which ended
silver5
in
Advanced Prostate Cancer
2 months ago
Cancerous thyroid nodules. Are they painful sometimes?
Id be really grateful for thoughts on this please. I'm awaiting surgery on a nodule that's suspicious for follicular cancer but obviously as we know, they can't be certain until its taken out. What i want to know is, has anyone had a painful nodule that can be really sore consistently (8 months now
Id be really grateful for thoughts on this please. I'm awaiting surgery on a nodule that's suspicious for follicular cancer but obviously as we know, they can't be certain until its taken out. What i want to know is, has anyone had a painful nodule that can be really sore consistently (8 months now
Aoifel73
in
Thyroid UK
2 months ago
metastatic prostate cancer
my dad has castrate resistant metastatic pc in bones- currently his psa is going up but his scans have been stable- he gets them Every three months- after Zytiga and xtandi are there still many treatments available- the scans were stable for over a year and he gets them Every three Months-
my dad has castrate resistant metastatic pc in bones- currently his psa is going up but his scans have been stable- he gets them Every three months- after Zytiga and xtandi are there still many treatments available- the scans were stable for over a year and he gets them Every three Months-
Chris52981
in
Advanced Prostate Cancer
5 months ago
bile reflux
I thought I would bring you all up to speed on my endoscopy yesterday ( Friday 15 March ). I have to say I was surprised by the results, I have Bile reflux, something I didn’t even know existed. It was a bit of a shock if I am honet. So me being me , I read up about it when I got home, as most things
I thought I would bring you all up to speed on my endoscopy yesterday ( Friday 15 March ). I have to say I was surprised by the results, I have Bile reflux, something I didn’t even know existed. It was a bit of a shock if I am honet. So me being me , I read up about it when I got home, as most things
Popsic
in
Oesophageal & Gastric Cancer
2 months ago
NUV-1511 drug-drug conjugate (DDC) to enter the clinical stage: phase 1
"Dosing the first patient with NUV-1511 marks a significant milestone for our proprietary DDC platform, from which we are developing potent oncology-focused chimeric small molecules designed to selectively deliver anti-cancer therapeutics to cancer cells, while mitigating effects on healthy non-target
"Dosing the first patient with NUV-1511 marks a significant milestone for our proprietary DDC platform, from which we are developing potent oncology-focused chimeric small molecules designed to selectively deliver anti-cancer therapeutics to cancer cells, while mitigating effects on healthy non-target
Maxone73
in
Advanced Prostate Cancer
2 months ago
Drugs interactions
I am on Lupron as the only current PC treatment. Testosterone is <>1% as of Dec/18. PCP is looking to get me on (very expensive , hard to get) Serostim to help me with HIV/PC wasting SE's Thoughts, please be kind as ADT makes me get upset for nothing. Thank you.
I am on Lupron as the only current PC treatment. Testosterone is <>1% as of Dec/18. PCP is looking to get me on (very expensive , hard to get) Serostim to help me with HIV/PC wasting SE's Thoughts, please be kind as ADT makes me get upset for nothing. Thank you.
Blueribbon63
in
Advanced Prostate Cancer
5 months ago
PSA after radiation and Hormone therapy prognosis
https://meetings.asco.org/abstracts-presentations/218387 I have be searching for some data on the impact of radiation and short term hormone therapy on Intermediate cancer. If anyone else has some additional data or experiences please post Background. I finishing up 25 doses of radiation to the
https://meetings.asco.org/abstracts-presentations/218387 I have be searching for some data on the impact of radiation and short term hormone therapy on Intermediate cancer. If anyone else has some additional data or experiences please post Background. I finishing up 25 doses of radiation to the
Mgtd
in
Prostate Cancer Network
5 months ago
Dutasteride and PSA dropping
I started taking dustasteride about 1 month ago because of high DHT and my PSA dropped from 10 to 5.5. I've read that you are supposed to double the PSA to get an "equivalent" non-dutasteride level of 11. Does anyone understand why we are supposed to double the PSA value when taking dutasteride?
I started taking dustasteride about 1 month ago because of high DHT and my PSA dropped from 10 to 5.5. I've read that you are supposed to double the PSA to get an "equivalent" non-dutasteride level of 11. Does anyone understand why we are supposed to double the PSA value when taking dutasteride?
janebob99
in
Prostate Cancer Network
5 months ago
Darolutamide failing after 2 years. Any success if I switch to Xandi or Zytiga or do I need to move to Pluvicto.
Dx 2018. PSA 16. Been on Orgovyx. Started Second line (Darolutamide) two years ago when PSA started to rise. PSA rose over the [u]last 5 months[/u] from 0.021 (August) to 0.48 I had a few bone mets and several lymph nodes when dx. Trying to find other treatments since I'm running out of Standard
Dx 2018. PSA 16. Been on Orgovyx. Started Second line (Darolutamide) two years ago when PSA started to rise. PSA rose over the [u]last 5 months[/u] from 0.021 (August) to 0.48 I had a few bone mets and several lymph nodes when dx. Trying to find other treatments since I'm running out of Standard
Longterm101
in
Advanced Prostate Cancer
5 months ago
4 years after thyroidectomy
total thyroidectomy for papillaire carcinoma my tsh is 0.5 on levo 75 Thyroglobulin =1 after my USS found a little nodes in thyroid area noother nodes detected my endo whant me to be off levo 1 month to do scintigraphy is there any other way to kow if my cancer is back . Thanks guy for feed back
total thyroidectomy for papillaire carcinoma my tsh is 0.5 on levo 75 Thyroglobulin =1 after my USS found a little nodes in thyroid area noother nodes detected my endo whant me to be off levo 1 month to do scintigraphy is there any other way to kow if my cancer is back . Thanks guy for feed back
Raoudha
in
Thyroid UK
2 months ago
Abiraterone vs Nubeqa
I've been on Lupron only for 5 years, metastatic to bones. Generic AA would be the next cheapest step, but I notice my new Medicare drug plan shows $2,800 for a year's worth of Nubeqa. Any advantage to going with Nubeqa other than possible difference in side effects?
I've been on Lupron only for 5 years, metastatic to bones. Generic AA would be the next cheapest step, but I notice my new Medicare drug plan shows $2,800 for a year's worth of Nubeqa. Any advantage to going with Nubeqa other than possible difference in side effects?
dhccpa
in
Advanced Prostate Cancer
5 months ago
Overall Survival With [177]Lu-PSMA-617 vs Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
Magnus1964
in
Advanced Prostate Cancer
5 months ago
Criteria for "my ADT has stopped working and we have to move to another"
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
jackwfrench
in
Advanced Prostate Cancer
5 months ago
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