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Status on Xtandi effect
Hi Folks, you may remember I was speculating that the Xtandi dosage was designed in the clinical trials to be at the max possible without incurring adverse side effects. There was little attention paid to the efficacy of the doses. My theory was that while we need a high dose to reach saturation, we
Hi Folks, you may remember I was speculating that the Xtandi dosage was designed in the clinical trials to be at the max possible without incurring adverse side effects. There was little attention paid to the efficacy of the doses. My theory was that while we need a high dose to reach saturation, we
Stoneartist
in
Advanced Prostate Cancer
2 years ago
Starting chemo for the first time 🤞
After 24 weeks of participating in a promising clinical trial, I now need to move on to the next viable treatment as my disease is progressing and my PSA continues to rise. I was told that I now need systemic treatment, and soon. I have to admit that when I was first told that I needed systemic treatment
After 24 weeks of participating in a promising clinical trial, I now need to move on to the next viable treatment as my disease is progressing and my PSA continues to rise. I was told that I now need systemic treatment, and soon. I have to admit that when I was first told that I needed systemic treatment
HopingForTheBest1
in
Advanced Prostate Cancer
2 years ago
Reply to jersey-jazz. I thought you might also be interested in my medical history.
If you don’t mind to read a long story, I would love to provide more details. I moved to US since 2000. I worked here and had insurance all the time but never think about to use it since I always think myself as a healthy person. My first diagnosed DCIS on 2012 was in Taiwan when I went back to visit
If you don’t mind to read a long story, I would love to provide more details. I moved to US since 2000. I worked here and had insurance all the time but never think about to use it since I always think myself as a healthy person. My first diagnosed DCIS on 2012 was in Taiwan when I went back to visit
s_yenju
in
SHARE Metastatic Breast Cancer
2 years ago
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Depression - Maybe the anti depressant Sertraline can help depression and fight prostate cancer?
I previously posted on Sertraline and prostate cancer, but this paper Is hot off the press. Translational Oncology Volume 16, February 2022, 101303 Translational Oncology Sertraline repositioning: an overview of its potential use as a chemotherapeutic agent after four decades of tumor reversal studies
I previously posted on Sertraline and prostate cancer, but this paper Is hot off the press. Translational Oncology Volume 16, February 2022, 101303 Translational Oncology Sertraline repositioning: an overview of its potential use as a chemotherapeutic agent after four decades of tumor reversal studies
Graham49
in
Advanced Prostate Cancer
2 years ago
Starting LU 177 , Later this month. Thats the good news, is this my swan song. If so a rams victory is in order.
I am very happy I do not not have to go abroad and spend a boat load of cash. I was finally called up too start Lu 177 stateside, Although I was having a conversation with my onc unrelated to treatment, and he was a bit of a buzz kill by stating this is all thats left on the table for me. No pressure
I am very happy I do not not have to go abroad and spend a boat load of cash. I was finally called up too start Lu 177 stateside, Although I was having a conversation with my onc unrelated to treatment, and he was a bit of a buzz kill by stating this is all thats left on the table for me. No pressure
Costarica1961
in
Advanced Prostate Cancer
2 years ago
Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomiz
I don't have the complete paper, but this link shows a lot of it. They gave 5cc of licorice twice a day, which equals 136 mg of polyphenol-rich extract of licorice. I don't know how this relates to my Organic Licorice Root Extract 20:1 Powder https://www.amazon.com/gp/product/B079N4Z72C/ref=ppx_yo_dt_b_asin_title_o06
I don't have the complete paper, but this link shows a lot of it. They gave 5cc of licorice twice a day, which equals 136 mg of polyphenol-rich extract of licorice. I don't know how this relates to my Organic Licorice Root Extract 20:1 Powder https://www.amazon.com/gp/product/B079N4Z72C/ref=ppx_yo_dt_b_asin_title_o06
Bolt_Upright
in
Cure Parkinson's
2 years ago
Happy to be here!
With everything that's been going on with my lung disease over the past few years, I often forget just how fortunate I am to still be here. In September 2003 I was diagnosed with chronic myeloid leukaemia at the age of 18. I was totally blindsided and the future looked bleak. The amazing treatments
With everything that's been going on with my lung disease over the past few years, I often forget just how fortunate I am to still be here. In September 2003 I was diagnosed with chronic myeloid leukaemia at the age of 18. I was totally blindsided and the future looked bleak. The amazing treatments
dodgylungrunner
British Lung Foundation
in
Lung Conditions Community Forum
2 years ago
Metachromatic leukodystrophy and the world's most expensive drug.
I'll post this. It's tangentially related to our disease. From The Guardian:
[u]Children in England with fatal condition to get world’s most expensive drug.[/u]
https://www.theguardian.com/society/2022/feb/04/children-in-england-with-fatal-condition-to-get-worlds-most-expensive-drug "Children
I'll post this. It's tangentially related to our disease. From The Guardian:
[u]Children in England with fatal condition to get world’s most expensive drug.[/u]
https://www.theguardian.com/society/2022/feb/04/children-in-england-with-fatal-condition-to-get-worlds-most-expensive-drug "Children
monkeybus
in
AMN EASIER
2 years ago
More promising work on the horizon. CAR T cell treatment.
Recent review in Nature. And, Google reveals at least one clinical trial at City of Hope. FYI. https://www.cityofhope.org/physician-news/car-t-for-prostate-cancer https://www.nature.com/articles/d41586-022-00241-0?utm_source=Nature+Briefing&utm_campaign=00eba5fa44-briefing-dy-20220203&utm_medium=email
Recent review in Nature. And, Google reveals at least one clinical trial at City of Hope. FYI. https://www.cityofhope.org/physician-news/car-t-for-prostate-cancer https://www.nature.com/articles/d41586-022-00241-0?utm_source=Nature+Briefing&utm_campaign=00eba5fa44-briefing-dy-20220203&utm_medium=email
kreg001
in
Advanced Prostate Cancer
2 years ago
Letter from Bianco's & Hoang's labs defending use of T3 and DTE in treatment
This letter is a reply to a rather critical one from Bonnema. It doesn't have a doi number so I've put it here in full. My only gripe is that they insist on " normal" TSH as being proof of proper dosing. However they don't damn the use of NDT(DTE). One can take heart from that. Dear Editor,
We thank
This letter is a reply to a rather critical one from Bonnema. It doesn't have a doi number so I've put it here in full. My only gripe is that they insist on " normal" TSH as being proof of proper dosing. However they don't damn the use of NDT(DTE). One can take heart from that. Dear Editor,
We thank
diogenes
in
Thyroid UK
2 years ago
HU Resistance/Intolerance Prognostic from Dr Gotlib
I came across this interview including Dr. Gotlib, Stanford MPN expert. It's regarding MDM Inhibitors for HU resistant/intolerant PV, MF "Experts Explain MDM2 Inhibition and Clinical Trial for MPN Patients" https://patientpower.info/myeloproliferative-neoplasms/emerging-research/experts-explain-mdm2
I came across this interview including Dr. Gotlib, Stanford MPN expert. It's regarding MDM Inhibitors for HU resistant/intolerant PV, MF "Experts Explain MDM2 Inhibition and Clinical Trial for MPN Patients" https://patientpower.info/myeloproliferative-neoplasms/emerging-research/experts-explain-mdm2
EPguy
in
MPN Voice
2 years ago
ANAVEX®2-73 (Blarcamesine) AVATAR Phase 3 Trial met Primary and Secondary Efficacy Endpoints - Rett syndrome
Primary and all secondary efficacy and safety endpoints met for the treatment of adult patients with Rett syndrome, with consistent improvements in RSBQ AUC (p = 0.037), ADAMS (p = 0.010) and CGI-I (p = 0.037) response Efficacy endpoints demonstrated statistically significant and clinically meaningful
Primary and all secondary efficacy and safety endpoints met for the treatment of adult patients with Rett syndrome, with consistent improvements in RSBQ AUC (p = 0.037), ADAMS (p = 0.010) and CGI-I (p = 0.037) response Efficacy endpoints demonstrated statistically significant and clinically meaningful
Hidden
in
Cure Parkinson's
2 years ago
Back at the beginning
Well, I didn't make the clinical trial do to the shinanigans during my masectomy operation. The day of my surgery my blood pressure went sky high and had injured my heart chambers..a bit. Healing but still need blood pressure pills ect. It had always been border line but really hadn't been checked due
Well, I didn't make the clinical trial do to the shinanigans during my masectomy operation. The day of my surgery my blood pressure went sky high and had injured my heart chambers..a bit. Healing but still need blood pressure pills ect. It had always been border line but really hadn't been checked due
Debbigbang
in
SHARE Metastatic Breast Cancer
2 years ago
Confusion As To Next Treatments - Carboplatin and Cabazitaxel
Thanks in advance! I was diagnosed at age 76 with stage 4 metastatic prostate cancer that has spread extensively to bones, lymph nodes and lungs. My profile contains a complete description of events including lab work, scan results and treatments. That was in June 2020. After treatment with Cosiodex
Thanks in advance! I was diagnosed at age 76 with stage 4 metastatic prostate cancer that has spread extensively to bones, lymph nodes and lungs. My profile contains a complete description of events including lab work, scan results and treatments. That was in June 2020. After treatment with Cosiodex
Mount_Rainier
in
Advanced Prostate Cancer
2 years ago
A good description of a mis-folded Protein that causes PD
Fatty Acid Length Predicts Parkinson’s Disease Risk FeaturedNeurologyNeuroscience ·December 8, 2021 Summary: Chains of fatty acids in the lysosome that are one-half nanometer longer than normal-length chains were associated with a degenerative form of Gaucher disease, a genetic condition related to
Fatty Acid Length Predicts Parkinson’s Disease Risk FeaturedNeurologyNeuroscience ·December 8, 2021 Summary: Chains of fatty acids in the lysosome that are one-half nanometer longer than normal-length chains were associated with a degenerative form of Gaucher disease, a genetic condition related to
Sapeye2020
in
Cure Parkinson's
2 years ago
Tablets not working
Ca125 back up to 900, Tamaxofen stopped not working. Not sure what's going to happen next. Another scan booked see how the brute is growing then see what oncologist says. Platinum resistant so got to find another chemo that dosnt effect my heart. I did ask about clinical trials she is seeing what's available
Ca125 back up to 900, Tamaxofen stopped not working. Not sure what's going to happen next. Another scan booked see how the brute is growing then see what oncologist says. Platinum resistant so got to find another chemo that dosnt effect my heart. I did ask about clinical trials she is seeing what's available
Sueithy
in
My Ovacome
2 years ago
ScienceofParkinsons: The road ahead: 2022
https://scienceofparkinsons.com/2022/01/20/road2022/ Top 5 #Parkinsons clinical trial results we will be looking out for in 2022: * Phase II Lixisenatide study results * Phase II Liraglutide study results * Phase II PT320 study results (Lots of GLP-1R data) * Phase II UDCA "UP study" results * Phase
https://scienceofparkinsons.com/2022/01/20/road2022/ Top 5 #Parkinsons clinical trial results we will be looking out for in 2022: * Phase II Lixisenatide study results * Phase II Liraglutide study results * Phase II PT320 study results (Lots of GLP-1R data) * Phase II UDCA "UP study" results * Phase
Hidden
in
Cure Parkinson's
2 years ago
Do the Covid vaccines alter the Thyroid blood test results?
Many of my friends who are diabetic have experienced elevated blood glucose levels after their Covid vaccination. There appear to be many more diabetic/prediabetics experiencing this than have been reported. I have just been searching the internet to see if there is are any reports of the Thyroid markers
Many of my friends who are diabetic have experienced elevated blood glucose levels after their Covid vaccination. There appear to be many more diabetic/prediabetics experiencing this than have been reported. I have just been searching the internet to see if there is are any reports of the Thyroid markers
telephonejunkie
in
Thyroid UK
2 years ago
ANNOVIS BIO ANNOUNCES POSITIVE FDA FEEDBACK FOR BUNTANETAP PHASE 3 CLINICAL DEVELOPMENT IN PARKINSON'S DISEASE (ANVS401)
https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?releaseID=111474&d=202201250900 The U.S. Food and Drug Administration (FDA) has given positive feedback to Annovis Bio’s plans to start two Phase 3 clinical trials of buntanetap (ANVS401) as an oral therapy for early- and
https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?releaseID=111474&d=202201250900 The U.S. Food and Drug Administration (FDA) has given positive feedback to Annovis Bio’s plans to start two Phase 3 clinical trials of buntanetap (ANVS401) as an oral therapy for early- and
Hidden
in
Cure Parkinson's
2 years ago
Clinical trials for Richter's transformation
Hello. I would like to ask if you know of any current clinical trials for patients with Richter's Transformation who have already reached the Car-T and it did not work for them. We have in our group a very young 22-year-old boy whose Car-Ts didn't work for him in the UK. They have told him that they
Hello. I would like to ask if you know of any current clinical trials for patients with Richter's Transformation who have already reached the Car-T and it did not work for them. We have in our group a very young 22-year-old boy whose Car-Ts didn't work for him in the UK. They have told him that they
Priss69
in
CLL Support
2 years ago
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