Experiences with

Prialt

Hi people 🙋‍♂️.. I've seen people ask about different vitamins and supplements to take to help our adhd...I thought I'd put this post as I do find them to help with focus and fatigue...I have found a fantastic company that clearly knows how they all work together due to the combinations of vitamins

Good morning all you gentlemen with PCa. There is often discussion about new information, clinical trials etc. I thought it might help us blokes with prostate cancer to know about the international standards for good trials. These are the CONSORT rules - "Consolidated standards of reporting

Hello everyone, We're having our first [i]The Truth About Liver Cancer[/i] workshop on Saturday, March 15, at 12 p.m. ET. The topic is Patient Perspectives. You'll meet three people who have or had different liver diseases that put them at a high risk for liver cancer. You can register

Hi everyone, I have been invited to participate in a clinical trial to investigate the efficacy of Lutetium Lu177 for early stage patients. My PSA has been rising steadily the last few months from 0.02 ug/l and is currently 0.22 ug/l. The trial will divide patients into 2 groups- Group A will be given

Here's a welcome article that explains all about BTK degraders; the next class of BTK drug after the success of the FDA approved covalent BTKis (acalabrutinib/Calquence, ibrutinib/Imbruvica and zanubrutinib/Brukinsa) and non-covalent BTKi pirtobrutinib/Jaypirca. [i][/i] [i]"Oral therapies targeting

This small-molecular reactivator is for TP53 mutations which is found in 50% of human cancers. Compound 26 (rezatapopt; PC14586), which had the most favorable plasma exposure, was evaluated for its ability to inhibit the growth of NUGC-3 tumor xenografts in nude mice. Oral administration of daily doses

[EDIT: I've purposely left this post Public so that other internet users can find it.] I like Microsopft Copilot, because it's built into my PC running Windows 10, and provides an attempt at references. But this sequence shows how repeatedly wrong it can be. So I only trust it as much

It's not yet Prostate cancer related, but I love it. It is a company traded on Nasdaq, so we are not talking about 3 guys that could be erased by some big pharma company. This is a company I would love to help to get to clinical trials! The company (I try not to include company names here wen I can)

In view of the current US administration’s hostility toward scientific research I am discouraged about finding a clinical trial I can participate in, while the increase in my PSA has my MO s changing their tune to now pursuing SOC. There are many factors that limit the trials I am willing to try, but

My own use of chamomile is mainly to help sleep. I cut into a chamomile tea bag and eat the contents washed down by a small amount of water. I don’t want to drink much fluid before bed to reduce the need to pee. It does help. Saffron and chamomile for depression Heliyon. 2022 Sep 30;8(10):e10774.

Real world seems to confirm clinical trial data in this case! A real-world study from the IRONMAN registry confirms that achieving an undetectable PSA nadir (<0.2 ng/mL) within the first year of treatment is linked to better long-term outcomes in metastatic hormone-sensitive prostate cancer (mHSPC).

Am getting my first treatment of cabizataxel/carboplatin/nivolumab/ipilimumab this coming Tuesday as part of the Duke CHAMP trial: https://www.dukehealth.org/clinical-trials/directory/pro00106278 Does anyone have recommendations/experiences on how to best reduce side effects? Claritin worked well

A study on homologous recombination repair (HRR) gene mutations in metastatic hormone-sensitive prostate cancer (mHSPC) found different impacts based on the specific gene altered. ATM mutations showed no significant effect on time to castration resistance (TTCR) or overall survival (OS), meaning outcomes

A new clinical trial shows CBP-1018, an experimental bi-ligand–drug conjugate, could be a promising treatment for mCRPC, as presented at ASCO GU 2025. Among 76 patients treated at effective doses, 88% had disease control, 20% had significant tumor shrinkage, and 60% saw tumor size reduction. At seven

Here we go...because diet and microbiome are not important someone said... 😜😜 A randomized clinical trial investigated how a phytochemical-rich food supplement, with or without a probiotic/prebiotic blend, affects prostate cancer progression. All 212 men, averaging 74.5 years old, received the supplement

A new population-adjusted analysis confirms that the combination of darolutamide, ADT, and docetaxel significantly improves survival in men with metastatic hormone-sensitive prostate cancer (mHSPC). By using advanced statistical methods to adjust for differences in patient populations across 12 clinical

CAR-T therapy has been used most successfully to treat some of the more acute blood cancers, less so in treating CLL and with limited success in solid tumours. "Autologous" CAR-T therapies involve a time-consuming and expensive process: the extraction of T cells from the patient, genetically engineering

Hello everyone, I have a different insurance provider for 2025 and their first order of business was to flag big-ticket treatments. Of course Actemra made it onto their list. They've agreed to cover its FDA-approved biosimilar, called Tyenne. As a GCA/ PMR sufferer currently stable (on weekly Actemra

BR111 is a dual-epitope antibody-drug conjugate (ADC) targeting ROR1, has received formal clinical trial approval from China's National Medical Products Administration (NMPA). This approval allows the company to initiate clinical trials to assess the safety and efficacy of BR111 in patients with ROR1

The real key point here, apart from the results this company is achieving in oncology with its microbiome approach, is this: take care of your microbiome. It's not just a fad or some new-age trend—it truly matters. Personally, after exercise, I believe it's the most important aspect of our disease that