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Chemo/Pluvicto or Clinical Trial?
I have stage 4, mcrpc with mets to pelvic lymph nodes and prostate. ADT (Firmagon and Zytiga) kept PSA undetectable for ~2.5 years, then PSA started to rise. I had radiation to prostate in March of this year, which did not help. I started a clinical trial in October at NYU (LAVA 1207 immunotherapy)
I have stage 4, mcrpc with mets to pelvic lymph nodes and prostate. ADT (Firmagon and Zytiga) kept PSA undetectable for ~2.5 years, then PSA started to rise. I had radiation to prostate in March of this year, which did not help. I started a clinical trial in October at NYU (LAVA 1207 immunotherapy)
carguy
in
Advanced Prostate Cancer
2 years ago
Glycine : said to reduce symptoms and reduce aggregation
https://www.michaeljfox.org/grant/modulation-glycine-treatment-parkinsons-disease Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity
https://www.michaeljfox.org/grant/modulation-glycine-treatment-parkinsons-disease Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity
Little_apple
in
Cure Parkinson's
2 years ago
Details of Inhibikase Trial Suspension
Many of us have been following Inhibikase and the recent suspension of trials by the FDA. Inhibikase just issued a press release regarding the concerns expressed by the FDA. "The FDA raised several points, summarized below, in their explanation of the basis for the clinical hold: Further evaluation of
Many of us have been following Inhibikase and the recent suspension of trials by the FDA. Inhibikase just issued a press release regarding the concerns expressed by the FDA. "The FDA raised several points, summarized below, in their explanation of the basis for the clinical hold: Further evaluation of
jimcaster
in
Cure Parkinson's
2 years ago
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An exciting new clinical trial called STEM-PD is due to start in Sweden and the UK for Parkinson’s.
The symptoms of Parkinson’s are caused by the loss of dopamine-producing nerve cells or neurons in the brain; and researchers have long proposed using cell transplantation as a treatment option for replacing these lost dopamine cells. One challenge presented to research teams however has been generating
The symptoms of Parkinson’s are caused by the loss of dopamine-producing nerve cells or neurons in the brain; and researchers have long proposed using cell transplantation as a treatment option for replacing these lost dopamine cells. One challenge presented to research teams however has been generating
Farooqji
in
Cure Parkinson's
2 years ago
Bionic chip reveals how some antibiotics can harm kidneys
[i]
From left, Amir Livne, Dr. Gil Shamai and Prof. Ron Kimmel, the computer scientists who developed the neural network that examines breast cancer scans. Photo courtesy of the Technion – Israel Institute of Technology
[/i] Breakthrough technology blends sensors and human tissue in a smart kidney
[i]
From left, Amir Livne, Dr. Gil Shamai and Prof. Ron Kimmel, the computer scientists who developed the neural network that examines breast cancer scans. Photo courtesy of the Technion – Israel Institute of Technology
[/i] Breakthrough technology blends sensors and human tissue in a smart kidney
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
2 years ago
Irisin reduces AS aggregation
Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced
Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced
Little_apple
in
Cure Parkinson's
2 years ago
Pluvicto increases radiographic progression-free survival (rPFS) before chemo
This is the early topline results from the
PSMAfore
trial. https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (abiraterone, enzalutamide, darolutamide
This is the early topline results from the
PSMAfore
trial. https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (abiraterone, enzalutamide, darolutamide
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
On goin results on bomedemstat (LSD1 Inhibitor)
Hi All, I have been part of this great group for the last year or so, and although I wish none of us were here, I’m glad to have found an online community that shares the same concerns as myself. I’m 37 years old now and I was diagnosed with ET in 2009 when I was 24, so it was kind of a shock, but
Hi All, I have been part of this great group for the last year or so, and although I wish none of us were here, I’m glad to have found an online community that shares the same concerns as myself. I’m 37 years old now and I was diagnosed with ET in 2009 when I was 24, so it was kind of a shock, but
jafar09
in
MPN Voice
2 years ago
Naringenin (NAR), a natural flavonoid, exhibits neuroprotection against PD-related pathology.
https://www.sciencedirect.com/science/article/abs/pii/S0028390821003865 Naringenin: A prospective therapeutic agent for Alzheimer's and Parkinson's disease https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.14415 of substantial evidence for naringenin's neuroprotective efficacy in several experimental
https://www.sciencedirect.com/science/article/abs/pii/S0028390821003865 Naringenin: A prospective therapeutic agent for Alzheimer's and Parkinson's disease https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.14415 of substantial evidence for naringenin's neuroprotective efficacy in several experimental
Little_apple
in
Cure Parkinson's
2 years ago
Broccoli Sprout Beverage can clear Acrolein
I am doing a deep dive on the benefits of Broccoli Sprouts and/or Sulforaphane. There seem to be a lot of benefits, so I am posting on them one benefit at a time. As I post more information, I will add the new information to a master document on Broccoli Sprouts - Sulforaphane so we end up with a cohesive
I am doing a deep dive on the benefits of Broccoli Sprouts and/or Sulforaphane. There seem to be a lot of benefits, so I am posting on them one benefit at a time. As I post more information, I will add the new information to a master document on Broccoli Sprouts - Sulforaphane so we end up with a cohesive
Bolt_Upright
in
Cure Parkinson's
2 years ago
Chronic lymphocytic leukemia treatment algorithm 2022
This 29 November 2022 review article published in the [i]Blood Cancer Journal[/i] presents an up-to-date treatment algorithm for CLL. https://www.nature.com/articles/s41408-022-00756-9 [i]"The treatment landscape for patients with chronic lymphocytic leukemia (CLL) has changed considerably with the
This 29 November 2022 review article published in the [i]Blood Cancer Journal[/i] presents an up-to-date treatment algorithm for CLL. https://www.nature.com/articles/s41408-022-00756-9 [i]"The treatment landscape for patients with chronic lymphocytic leukemia (CLL) has changed considerably with the
CLLerinOz
Administrator
in
CLL Support
2 years ago
OVM-200 Phase 1 clinical trial ( vaccine)
I thought I would start a new thread as the original was about the decision making but now I’m in it I realise a clean thread may help. So today is day 15 of the trial and I am getting the second dose of the vaccine ( subject to clearing the screening this morning). I will then be observed for 4 hours
I thought I would start a new thread as the original was about the decision making but now I’m in it I realise a clean thread may help. So today is day 15 of the trial and I am getting the second dose of the vaccine ( subject to clearing the screening this morning). I will then be observed for 4 hours
Brysonal
in
Fight Prostate Cancer
2 years ago
Lecanemab, The Big Alzheimer's Breakthrough?
Some exciting news in today's press. https://www.bbc.co.uk/news/health-63749586 A new drug in the battle against Alzheimer's that might, just might, be the turning point. The drug, Lecanemab, slowed the progress of the disease in clinical trials, and despite some nasty side effects was hailed by the
Some exciting news in today's press. https://www.bbc.co.uk/news/health-63749586 A new drug in the battle against Alzheimer's that might, just might, be the turning point. The drug, Lecanemab, slowed the progress of the disease in clinical trials, and despite some nasty side effects was hailed by the
Chappychap
in
British Heart Foundation
2 years ago
Any new treatments, people who have tried a clinical trial?
Has anyone on here ever done any clinical trial? There have been a lot of things that have come up, but has anyone tried any of them??? I know that they are not our for the public, but things like PS128 and other trials. Has anyone been part of a clinical trial?
Has anyone on here ever done any clinical trial? There have been a lot of things that have come up, but has anyone tried any of them??? I know that they are not our for the public, but things like PS128 and other trials. Has anyone been part of a clinical trial?
smv123
in
Cure Parkinson's
2 years ago
Potential disease-modifying therapy enters Phase 2
"Following the review of the data of the 101 trial, the drug advanced to the Phase II 201 trial (NCT05424276). This is a 12-week, randomized, double-blind, multi-center, placebo-controlled, dose-ranging clinical trial of three IkT 148009 doses in patients with untreated Parkinson's disease." -------
"Following the review of the data of the 101 trial, the drug advanced to the Phase II 201 trial (NCT05424276). This is a 12-week, randomized, double-blind, multi-center, placebo-controlled, dose-ranging clinical trial of three IkT 148009 doses in patients with untreated Parkinson's disease." -------
PDWarrior1900
in
Cure Parkinson's
2 years ago
Trials
Does anyone have any experience and or recommendations with respect to"TrialJectory", My understanding is that the Company attempts to connect cancer patients with clinical trials. Thank you
Does anyone have any experience and or recommendations with respect to"TrialJectory", My understanding is that the Company attempts to connect cancer patients with clinical trials. Thank you
Univs
in
Advanced Prostate Cancer
2 years ago
Is THIS the MIRACLE we've all been waiting for??? WATCH THIS VIDEO!
There have been recent posts about Stanford University's development of a 'glove' that counteracts PD symptoms (and several other brain diseases!). This video was released in August, 2022. Watch this 26 minute video interview of one of the Stanford researchers, Peter Tass (M.D., MDS, neurosurgeon, plus
There have been recent posts about Stanford University's development of a 'glove' that counteracts PD symptoms (and several other brain diseases!). This video was released in August, 2022. Watch this 26 minute video interview of one of the Stanford researchers, Peter Tass (M.D., MDS, neurosurgeon, plus
PDWarrior1900
in
Cure Parkinson's
2 years ago
Nubeqa failing onto C-94676 clinical trial
I just thought I would update my latest progression, scan findings, and plan of care established. You can view my profile but in a nutshell went to a free screening in the fall of 2012 but they never contacted me until early 2013 where 12 core biopsy revealed Stage IV M1b with extensive lymph node and
I just thought I would update my latest progression, scan findings, and plan of care established. You can view my profile but in a nutshell went to a free screening in the fall of 2012 but they never contacted me until early 2013 where 12 core biopsy revealed Stage IV M1b with extensive lymph node and
wagscure259
in
Advanced Prostate Cancer
2 years ago
NUREX - 2127 ONE YEAR ANNIVERSARY STARTING CYCLE 14
Here's an update of my second clinical trial. I started this BTK degraeder November 11, 2021, now here I am, over a year later and doing really well. Other than neutropenia, and having to get a monthly neulasta injection, my blood counts have continued trending to normal levels. Here are my starting
Here's an update of my second clinical trial. I started this BTK degraeder November 11, 2021, now here I am, over a year later and doing really well. Other than neutropenia, and having to get a monthly neulasta injection, my blood counts have continued trending to normal levels. Here are my starting
steve5441
in
CLL Support
2 years ago
Canada's Tania Sona Smith - Powerful summary of recent BTA's twitter arguments against T3
Please read this! Someone (we have our suspicions) from BTA has been tweeted alarming things recently and is causing outrage amongst thyroid patients. It is on the Thyroid Patients Canada Facebook page, for this on FB. I've copied it here:
Recently on Twitter, The British Thyroid Association (
Please read this! Someone (we have our suspicions) from BTA has been tweeted alarming things recently and is causing outrage amongst thyroid patients. It is on the Thyroid Patients Canada Facebook page, for this on FB. I've copied it here:
Recently on Twitter, The British Thyroid Association (
TaraJR
in
Thyroid UK
2 years ago
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