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Vagal Nerve Stimulation (tVNS) Research Summary
tyrosine hydroxylase (TH) in the SN and the levels of inflammatory cytokines in the ventral midbrain were evaluated. 11 Compared with 6-OHDA treats rats, aVNS treatment significantly improved motor deficits, increased TH and α7 nAChR expression, and reduced the levels of inflammatory cytokines (tumor
necrosis
tyrosine hydroxylase (TH) in the SN and the levels of inflammatory cytokines in the ventral midbrain were evaluated. 11 Compared with 6-OHDA treats rats, aVNS treatment significantly improved motor deficits, increased TH and α7 nAChR expression, and reduced the levels of inflammatory cytokines (tumor
necrosis
House2
in
Cure Parkinson's
2 years ago
Treatment for Osteoporosis
I have refused Alendronic acid because of side effects - Osteo
necrosis
of the jaw, principally. Phyllis Wilson
I have refused Alendronic acid because of side effects - Osteo
necrosis
of the jaw, principally. Phyllis Wilson
Pheewills
in
Bone Health and Osteoporosis UK
2 years ago
bad RLS, recent hip replacement
She has had RLS for many years, and 2 years ago she was diagnosed with avascular
necrosis
in her hip, a very painful condition, for 2 years she was limping and in pain, during that time her RLS increased also.
She has had RLS for many years, and 2 years ago she was diagnosed with avascular
necrosis
in her hip, a very painful condition, for 2 years she was limping and in pain, during that time her RLS increased also.
daisydaisy26
in
Restless Legs Syndrome
2 years ago
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Treatment for finger-bending disease may be ‘gamechanger’
be ‘gamechanger’ Clinical trial seems to show Dupuytren’s disease reversed by rheumatoid arthritis drug[/i] Full article here: https://www.theguardian.com/science/2022/may/05/dupuytrens-disease-hand-finger-bending-treatment-clinical-trial-oxford-university Full Lancet paper: [i]
Anti-tumour
be ‘gamechanger’ Clinical trial seems to show Dupuytren’s disease reversed by rheumatoid arthritis drug[/i] Full article here: https://www.theguardian.com/science/2022/may/05/dupuytrens-disease-hand-finger-bending-treatment-clinical-trial-oxford-university Full Lancet paper: [i]
Anti-tumour
helvella
Thyroid UK
in
Thyroid UK
2 years ago
Curcumin Real Clinical Study, Anti Inflam
<<Get blood samples to evaluate the supplementation effects in inflammatory biomarkers- factor nuclear kappa B (NFkB), interleukin 6 (IL-6), tumor
necrosis
factor alpha (TNF-alpha)>> They were using 1500mg/day plus piperine which makes Curc more available.
<<Get blood samples to evaluate the supplementation effects in inflammatory biomarkers- factor nuclear kappa B (NFkB), interleukin 6 (IL-6), tumor
necrosis
factor alpha (TNF-alpha)>> They were using 1500mg/day plus piperine which makes Curc more available.
EPguy
in
MPN Voice
2 years ago
What does my dads PET scan results mean?
There are regions of minimal radio tracer uptake within the lymph node conglomeration specifically withinthe lateral aspect, likely due to
necrosis
(image 153). No definite suspicious radiotracer avid lymph nodes within the pelvis.Postsurgical changes of radical prostatectomy.
There are regions of minimal radio tracer uptake within the lymph node conglomeration specifically withinthe lateral aspect, likely due to
necrosis
(image 153). No definite suspicious radiotracer avid lymph nodes within the pelvis.Postsurgical changes of radical prostatectomy.
Bighawk11
in
Advanced Prostate Cancer
2 years ago
Osteonecrosis of the knee
Necrosis
of the knee: Has anyone had this condition? If so, I would greatly appreciate any advice, as I suspect that I may have this condition.
Necrosis
of the knee: Has anyone had this condition? If so, I would greatly appreciate any advice, as I suspect that I may have this condition.
Musicl
in
Bone Health and Osteoporosis UK
3 years ago
Novel COVID-19 Vaccine Shows Promise for People with Leukemia and Lymphoma
Tandler said that the induced CD4+ T cells “displayed a desired multifunctional phenotype” that was positive for cytokines such as interleukin 2, tumor
necrosis
factor, and interferon gamma. “This resembles the phenotype after natural infection,” she said.
Tandler said that the induced CD4+ T cells “displayed a desired multifunctional phenotype” that was positive for cytokines such as interleukin 2, tumor
necrosis
factor, and interferon gamma. “This resembles the phenotype after natural infection,” she said.
bennevisplace
in
CLL Support
2 years ago
Saw the Rheumatologist
I was shocked to hear that in my notes it says 'Steriod enduced
necrosis
of the left hip'. At no stage have I heard this phrase used in connection to my severally crumbling hip, now thankfully replaced. Any thoughts don't know what to feel about this new information.
I was shocked to hear that in my notes it says 'Steriod enduced
necrosis
of the left hip'. At no stage have I heard this phrase used in connection to my severally crumbling hip, now thankfully replaced. Any thoughts don't know what to feel about this new information.
Hiibilly
in
PMRGCAuk
3 years ago
Allogeneic Bone Marrow–Derived Mesenchymal Stem Cell Safety in Idiopathic Parkinson's Disease
Peripheral inflammation markers appear to be reduced at 52 weeks in the highest dose including, tumor
necrosis
factor‐α (P < 0.05), chemokine (C‐C motif) ligand 22 (P < 0.05), whereas brain‐derived neurotrophic factor (P < 0.05) increased.
Peripheral inflammation markers appear to be reduced at 52 weeks in the highest dose including, tumor
necrosis
factor‐α (P < 0.05), chemokine (C‐C motif) ligand 22 (P < 0.05), whereas brain‐derived neurotrophic factor (P < 0.05) increased.
Bolt_Upright
in
Cure Parkinson's
2 years ago
Dental problems & alendronic acid…anybody had ONJ (necrosis of jaw) please?
She thinks it’s best to have the tooth ‘capped off’ & says it won’t be a useful, chewing tooth, but smooth on top, & no risk of adrenal insufficiency or
necrosis
of the jaw.
She thinks it’s best to have the tooth ‘capped off’ & says it won’t be a useful, chewing tooth, but smooth on top, & no risk of adrenal insufficiency or
necrosis
of the jaw.
Pixix
in
PMRGCAuk
3 years ago
No idea where to go next
I'm very concerned I have developed Avascular
necrosis
of the knees and hip but he never even agreed to send me for an X ray. Was I wrong about the fact the double positive test should always be taken into account even if later you got negative?
I'm very concerned I have developed Avascular
necrosis
of the knees and hip but he never even agreed to send me for an X ray. Was I wrong about the fact the double positive test should always be taken into account even if later you got negative?
Newcastlelad
in
Hughes Syndrome APS Forum
2 years ago
Really bad DEXA scan result
It's this awful
necrosis
of the jaw which is a side effect. So, waiting for a dentist appointment, then a blood test to see if all is well to go ahead. Hating it all!
It's this awful
necrosis
of the jaw which is a side effect. So, waiting for a dentist appointment, then a blood test to see if all is well to go ahead. Hating it all!
strawclutching
in
PMRGCAuk
3 years ago
Analysis of type Th1 and Th2 cytokines in patients with prostate cancer
In
Th1 immunity
, cells produce pro-inflammatory cytokines, such as
interleukin-2 (IL2)
, interferon-gamma (IFN-γ), and tumor
necrosis
factor-beta (TNF-β). In
Th2 immunity
, cells produce antiinflammatory cytokines, such as IL-4, IL-5, IL-6,
IL-10
, and IL-13.
In
Th1 immunity
, cells produce pro-inflammatory cytokines, such as
interleukin-2 (IL2)
, interferon-gamma (IFN-γ), and tumor
necrosis
factor-beta (TNF-β). In
Th2 immunity
, cells produce antiinflammatory cytokines, such as IL-4, IL-5, IL-6,
IL-10
, and IL-13.
Hidden
in
Advanced Prostate Cancer
2 years ago
Nicotine and inflammatory neurological disorders
to nACh receptor activation, including presynaptic pathways involved in control of neurotransmitter release (dopamine, ACh, GABA, and glutamate) and postsynaptic pathways involved in apoptosis (phospholipase C, arachidonic acid, reactive oxygen species, neuronal nitric oxide synthase, and cGMP) and
necrosis
to nACh receptor activation, including presynaptic pathways involved in control of neurotransmitter release (dopamine, ACh, GABA, and glutamate) and postsynaptic pathways involved in apoptosis (phospholipase C, arachidonic acid, reactive oxygen species, neuronal nitric oxide synthase, and cGMP) and
necrosis
SilentEchoes
in
Cure Parkinson's
3 years ago
Some Interesting Information - Parkin-mediated Mitophagy
UA also led to an overall reduction of some pro-inflammatory cytokines, such as interferon gamma (IFN-γ), interleukin-1 beta (IL-1β), and tumor
necrosis
factor alpha (TNF-α) (Figure 3D). Average baseline levels of these pro-inflammatory cytokines were low in this population.
UA also led to an overall reduction of some pro-inflammatory cytokines, such as interferon gamma (IFN-γ), interleukin-1 beta (IL-1β), and tumor
necrosis
factor alpha (TNF-α) (Figure 3D). Average baseline levels of these pro-inflammatory cytokines were low in this population.
John_morris71
in
Cure Parkinson's
2 years ago
possible explanation for jaw issues with Zometa...
for some reason, it actually DECREASES the blood flow to the jaw....hence the
necrosis
issues. no blood flow equals tissue dies (necroses). this was just a very small portion of the article i was reading....wasn't even about this issue...but i came across it. found it really interesting.
for some reason, it actually DECREASES the blood flow to the jaw....hence the
necrosis
issues. no blood flow equals tissue dies (necroses). this was just a very small portion of the article i was reading....wasn't even about this issue...but i came across it. found it really interesting.
kokopelli2017
in
SHARE Metastatic Breast Cancer
3 years ago
Access to Covid treatment and vaccines
months targeted therapy for autoimmune disease, such as JAK inhibitors or biologic immune modulators including B-cell targeted therapies (including rituximab but in this case the recipient would be considered immunosuppressed for a 6-month period), T-cell co-stimulation modulators, monoclonal tumour
necrosis
months targeted therapy for autoimmune disease, such as JAK inhibitors or biologic immune modulators including B-cell targeted therapies (including rituximab but in this case the recipient would be considered immunosuppressed for a 6-month period), T-cell co-stimulation modulators, monoclonal tumour
necrosis
Moomin8
in
NRAS
2 years ago
Paper on Misc Mutations
-- Another study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465511/ <<Cytokines levels are higher in myelofibrosis compared to PV and ET, with higher IL-2, sIL-2Rα, IL-6 and tumour
necrosis
factor α (TNFa)>> NAC supplement improves IL-6, and TNFa in various studies. -- Triple Neg isn't: <<Previously
-- Another study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465511/ <<Cytokines levels are higher in myelofibrosis compared to PV and ET, with higher IL-2, sIL-2Rα, IL-6 and tumour
necrosis
factor α (TNFa)>> NAC supplement improves IL-6, and TNFa in various studies. -- Triple Neg isn't: <<Previously
EPguy
in
MPN Voice
3 years ago
Same as Carole, “new....well sort of ; )”
After several treatments, I had avascular
necrosis
which cause me limping. After one treatment, I had vocal cord paralysis which made hoarseness and shortness of breath when I am talking. However, I still try my best to go out traveling and hiking. Using my hoarse voice to communicate with others.
After several treatments, I had avascular
necrosis
which cause me limping. After one treatment, I had vocal cord paralysis which made hoarseness and shortness of breath when I am talking. However, I still try my best to go out traveling and hiking. Using my hoarse voice to communicate with others.
s_yenju
in
SHARE Metastatic Breast Cancer
3 years ago
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